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Collagenolytic proteinases in keratoconus
American Journal of Ophthalmology, 2006To study the proteolytic phenomena contributing to the pathogenesis of keratoconus, corneal enzymes with potential to cleave fibrillar collagen were studied.Immunohistochemical labeling was undertaken of conventional and novel mammalian collagenases (MMP-1, -2, -8, -13, and -14) of the matrix metalloproteinase (MMP) family and other collagenolytic ...
Zygmunt, Mackiewicz +5 more
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Proteinase‐activated receptor activation by coagulation proteinases
Drug Development Research, 2003AbstractCoagulation proteinases signal through proteinase activated receptors (PARs). Thrombin‐dependent PAR signaling on platelets is essential for hemostasis, but regulation of inflammation by PAR‐signaling is increasingly recognized as an important aspect of other pro‐ and anticoagulant pathways.
Matthias Riewald, Wolfram Ruf
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Journal of Histochemistry & Cytochemistry, 1981
Our interest in proteolytic enzymes derives from our work on the pathogenesis of multiple sclerosis (MS). In this disease of the central nervous system the myelin sheaths enveloping the axons disintegrate, usually in a patchy manner beginning around small veins or near the ventricles, resulting in lesions or “plaques.” The cause of MS is still unknown.
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Our interest in proteolytic enzymes derives from our work on the pathogenesis of multiple sclerosis (MS). In this disease of the central nervous system the myelin sheaths enveloping the axons disintegrate, usually in a patchy manner beginning around small veins or near the ventricles, resulting in lesions or “plaques.” The cause of MS is still unknown.
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British Medical Bulletin, 1995
The primary agents responsible for cartilage and bone destruction in joint diseases are active proteinases degrading collagen and proteoglycan. All four main classes of proteolytic enzymes are involved in either the normal turnover of connective tissue or its pathological destruction.
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The primary agents responsible for cartilage and bone destruction in joint diseases are active proteinases degrading collagen and proteoglycan. All four main classes of proteolytic enzymes are involved in either the normal turnover of connective tissue or its pathological destruction.
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Proteinase Inhibitors and Proteinases of Human Semen
1974During the First International Research Conference on Proteinase Inhibitors, a survey was presented concerning the proteinases of spermatozoa and seminal plasma as was known until that time [1, 2]. In summary, a proteinase from rabbit spermatozoa was purified and characterized, and shown to differ from other known pro-teolytic enzymes. It was given the
L. J. D. Zaneveld +3 more
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