eLife, 2020 Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels.
Vincenza Caolo +8 more
doaj +1 more source
Identification of three high molecular mass cysteine proteinases from rat skeletal muscle [PDF]
, 1983 Three cysteine proteinases were isolated from the post-myofibrillar fraction of rat skeletal muscle. Proteinase I preferentially hydrolyzes Z-Phe—Arg-NMec with pH optimum at 8–9.
Dahlmann, B., Kuehn, L., Reinauer, H.
core +1 more source
Molecular docking studies on Jensenone from eucalyptus essential oil as a potential inhibitor of COVID 19 corona virus infection [PDF]
arXiv, 2020 COVID-19, a member of corona virus family is spreading its tentacles across the world due to lack of drugs at present. However, the main viral proteinase (Mpro/3CLpro) has recently been regarded as a suitable target for drug design against SARS infection due to its vital role in polyproteins processing necessary for coronavirus reproduction.
arxiv
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
The major neutral proteinase of Entamoeba histolytica. [PDF]
, 1986 FPLC anion-exchange and chromatofocusing chromatography were used to purify the major neutral proteinase from secretions of axenically cultured Entamoeba histolytica trophozoites.
Allen, S +3 more
core
Critical Point Mutations for Hepatitis C Virus NS3 Proteinase [PDF]
, 1998 The hepatitis C virus NS3 proteinase plays an essential role in processing of HCV nonstructural precursor polyprotein. To detect its processing activity, we developed a simpletrans-cleavage assay.
Kimura, Junko +6 more
core +1 more source
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Biofilm, proteinase and phospholipase production by Candida albicans isolates from a hospital in Thailand [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2023 This study aimed to determine biofilm formation, and production of phospholipase and proteinase in 73 clinical isolates of Candida albicans. Biofilms formed in a 96-well plate were quantified by crystal violet staining.
Srisuda Pannanusorn +2 more
doaj
Comparative Studies on the Interaction of Proteinase-K with Nano-CuO and Copper Ions [PDF]
Journal of Nanostructures, 2012 The interaction of copper oxide nanoparticles and copper ions and proteinase K from Tritirachium album Limber has been investigated employing UV spectroscopy and kinetics measurements.
P. Nooraei +4 more
doaj +1 more source
The natural polyphenol fortunellin and its structural analogs are inhibitors of the SARS-CoV-2 main proteinase dimerization, as revealed by molecular simulation studies [PDF]
arXiv, 2020 3CL-Pro (or M-Pro) is the SARS-CoV-2 main protease, acting as a homodimer, is responsible for the cleavage of the large polyprotein 1ab transcript in proteins acting on viral growth and replication. 3CL-Pro has been one of the most studied SARS-CoV-2 proteins and the subject of therapeutic interventions, targeting its catalytic domain. A number of drug
arxiv