Results 71 to 80 of about 427,886 (292)

Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. [PDF]

, 2009
The innate immune response of airway epithelial cells to airborne allergens initiates the development of T cell responses that are central to allergic inflammation.
Angkasekwinai, Pornpimon, Barranco, Wade T, Corry, David B, Dong, Chen, Goswami, Sangeeta, Greenlee, Kendra J, Kheradmand, Farrah, Polikepahad, Sumanth, Redding, David, Seryshev, Alexander, Shan, Ming, Singh, Bhupinder, Song, Li-zhen, Sur, Sanjiv, Woodruff, Prescott   +14 more
core  

Helical mutations in type I collagen that affect the processing of the amino-propeptide result in an Osteogenesis Imperfecta/Ehlers-Danlos Syndrome overlap syndrome [PDF]

, 2013
Background: Whereas mutations affecting the helical domain of type I procollagen classically cause Osteogenesis Imperfecta (OI), helical mutations near the amino (N)-proteinase cleavage site have been suggested to result in a mixed OI/Ehlers-Danlos ...
De Paepe, Anne, Goemans, Nathalie, Gyftodimou, Yolanda, Holmberg, Eva, Lopez-Gonzalez, Vanesa, Malfait, Fransiska, Mortier, Geert, Nampoothiri, Sheela, Petersen, Michael Bjorn, Symoens, Sofie   +9 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comparing the frequency, antifungal susceptibility, and enzymatic profiles of the oral fungal composition in patients with and without Alzheimer's disease admitted to a neurology clinic

Frontiers in Cellular and Infection Microbiology
BackgroundStudies have shown that changes in the frequency of oral microorganisms may play a key role in the development of Alzheimer's disease (AD). However, no research has been conducted on the oral fungal composition in AD-patients. The present study
Mandana Golipoor, Zahra Rafat, Alia Saberi, Davoud Roostaei, Amir-Mohammad Shabanpour   +4 more
doaj   +1 more source

Coffee cysteine proteinases and related inhibitors with high expression during grain maturation and germination

BMC Plant Biology, 2012
Background Cysteine proteinases perform multiple functions in seeds, including participation in remodelling polypeptides and recycling amino acids during maturation and germination.
Lepelley Maud, Amor Mohamed, Martineau Nelly, Cheminade Gerald, Caillet Victoria, McCarthy James   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Antimalarial potential of ethanol extract, and anti-inflammatory properties of flavonoid-, terpenoid-, and alkaloid-rich fractions of Sida linifolia L.

Food Materials Research
Sida linifolia L. has been employed ethnomedicinally in the treatment of inflammatory diseases such as whitlow and malaria but is yet to be scientifically validated for use in the management of ailments.
Nicodemus Emeka Nwankwo, Philip Nwachukwu Ashiakpa   +1 more
doaj   +1 more source

Activation of Proteinase 3 Contributes to Nonalcoholic Fatty Liver Disease and Insulin Resistance

Molecular Medicine, 2016
Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes.
Erik J M Toonen, Andreea-Manuela Mirea, Cees J Tack, Rinke Stienstra, Dov B Ballak, Janna A van Diepen, Anneke Hijmans, Triantafyllos Chavakis, Wim H Dokter, Christine T N Pham, Mihai G Netea, Charles A Dinarello, Leo A B Joosten   +12 more
doaj   +1 more source

Import of honeybee prepromelittin into the endoplasmic reticulum [PDF]

, 1987
Honeybee prepromelittin is correctly processed and imported by dog pancreas microsomes. Insertion of prepromelittin into microsomal membranes, as assayed by signal sequence removal, does not depend on signal recognition particle (SRP) and docking protein.
Müller, Günter, Zimmermann, Richard
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source