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The proteinase inhibitors of plants and micro-organisms
Phytochemistry, 1977M. Richardson
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Proteinase Inhibitors and Proteinases of Human Semen
1974During the First International Research Conference on Proteinase Inhibitors, a survey was presented concerning the proteinases of spermatozoa and seminal plasma as was known until that time [1, 2]. In summary, a proteinase from rabbit spermatozoa was purified and characterized, and shown to differ from other known pro-teolytic enzymes. It was given the
L. J. D. Zaneveld +3 more
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Proteinases and their Inhibitors in Cells and Tissues
Progress in Histochemistry and Cytochemistry, 1989A large body of evidence has been assembled to indicate the substantial importance of proteolytic processes in various physiological functions. It has recently become clear too that endo-acting peptide bond hydrolases provisionally characterized and classified at present as serine, cysteine, aspartic and metallo together with unknown catalytic ...
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International Journal of Peptide and Protein Research, 1979
Investigations have been carried out on the complex formed between sorghum Inhibitor III and α‐chymotrypsin by physico‐chemical methods. An apparent dissociation constant (Ki) of 4.0 times 10‐8 M has been calculated for the complex. This enzyme‐inhibitor complex was isolated by gel filtration on Sephadex G‐75 and a molecular weight of 48,000 was ...
Kumar, Harish PM +2 more
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Investigations have been carried out on the complex formed between sorghum Inhibitor III and α‐chymotrypsin by physico‐chemical methods. An apparent dissociation constant (Ki) of 4.0 times 10‐8 M has been calculated for the complex. This enzyme‐inhibitor complex was isolated by gel filtration on Sephadex G‐75 and a molecular weight of 48,000 was ...
Kumar, Harish PM +2 more
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The involvement of extracellular proteinases and proteinase inhibitors in mammalian fertilization
Biotechnology and Applied Biochemistry, 1994Extracellular proteinases and proteinase inhibitors have been known to play many important roles in various biological systems. They are also important for reproductive functions of the mammals. Kallikrein stimulates human sperm motility. Porcine antithrombin III (AT III) has been identified to be a sperm-motility-stimulating protein and a ...
S L, Lee, Y H, Wei
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Proteinases and their inhibitors in the immune system
2003The most important roles of proteinases in the immune system are found in apoptosis and major histocompatibility complex (MHC) class II-mediated antigen presentation. A variety of cysteine proteinases, serine proteinases, and aspartic proteinases as well as their inhibitors are involved in the regulation of apoptosis in neutrophils, monocytes, and ...
Marco van Eijk +3 more
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Biochemistry of Natural Proteinase Inhibitors
Angewandte Chemie International Edition in English, 1974AbstractThe natural inhibitors of proteolytic enzymes are proteins. These inhibitors associate reversibly with the enzymes to form stoichiometric protein‐protein complexes, in which substrate‐analogous association at the active center of the enzyme results in competitive inhibition of all catalytic functions.
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Proteinase inhibitor in human tears
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1971Abstract Human tears contain an inhibitor of trypsin and chymotrypsin. Its molecular weight, between 3000 and 9000, is probably similar to that of the inhibitor from bovine organs, namely 6500. On electrophoresis at pH 8.65 the inhibitor moves toward the cathode.
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Saquinavir: An HIV Proteinase Inhibitor
1996The human immunodeficiency virus (HIV) proteinase has been recently identified as a potential target, distinct from reverse transcriptase, for antiretroviral therapy.1 Although reverse transcriptase inhibitors block viral replication in newly-infected cells by preventing this early step in the HIV replicative cycle, such antiretrovirals have no effect ...
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