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Collagenolytic proteinases in keratoconus
American Journal of Ophthalmology, 2006To study the proteolytic phenomena contributing to the pathogenesis of keratoconus, corneal enzymes with potential to cleave fibrillar collagen were studied.Immunohistochemical labeling was undertaken of conventional and novel mammalian collagenases (MMP-1, -2, -8, -13, and -14) of the matrix metalloproteinase (MMP) family and other collagenolytic ...
Timo Tervo +5 more
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Proteinase Inhibitors and Proteinases of Human Semen
1974During the First International Research Conference on Proteinase Inhibitors, a survey was presented concerning the proteinases of spermatozoa and seminal plasma as was known until that time [1, 2]. In summary, a proteinase from rabbit spermatozoa was purified and characterized, and shown to differ from other known pro-teolytic enzymes. It was given the
Gebhard F.B. Schumacher +3 more
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2021
Microglial cells may be seen as a relay station between the periphery and central nervous system (CNS) – they are tasked with modulating signals from the periphery to protect the CNS from potential harm. As such, microglial cells are known as the sentinels of the brain.
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Microglial cells may be seen as a relay station between the periphery and central nervous system (CNS) – they are tasked with modulating signals from the periphery to protect the CNS from potential harm. As such, microglial cells are known as the sentinels of the brain.
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Substrate recognition by proteinases
Faraday Discussions, 1992The molecular recognition of limited proteolytic site substrates by serine proteinases has been compared and contrasted to the recognition of serine proteinase inhibitors, utilising the coordinate sets contained in the Brookhaven Protein Databank. Most families of these inhibitors are known to possess a structurally conserved recognition motif at their
Hubbard, Simon J. +2 more
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Proteinase 3. A neutrophil proteinase with activity on platelets.
The Journal of Immunology, 1994Abstract Purified proteinase 3 (PR3) devoid of any elastase (HLE) and cathepsin G (Cat.G) contaminants, was prepared from azurophilic granules of human polymorphonuclear neutrophils by using a novel procedure. Although unable to induce platelet activation (up to 25 micrograms/ml) by itself, PR3 at a concentration as low as 2.5 micrograms/
P, Renesto +4 more
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Proteinase‐activated receptor activation by coagulation proteinases
Drug Development Research, 2003AbstractCoagulation proteinases signal through proteinase activated receptors (PARs). Thrombin‐dependent PAR signaling on platelets is essential for hemostasis, but regulation of inflammation by PAR‐signaling is increasingly recognized as an important aspect of other pro‐ and anticoagulant pathways.
Wolfram Ruf, Matthias Riewald
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The involvement of extracellular proteinases and proteinase inhibitors in mammalian fertilization
Biotechnology and Applied Biochemistry, 1994Extracellular proteinases and proteinase inhibitors have been known to play many important roles in various biological systems. They are also important for reproductive functions of the mammals. Kallikrein stimulates human sperm motility. Porcine antithrombin III (AT III) has been identified to be a sperm-motility-stimulating protein and a ...
Yau-Huei Wei, Shuang-Lin Lee
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Invivo biosynthesis of vacuolar proteinases in proteinase mutants of Saccharomycescerevisiae
Biochemical and Biophysical Research Communications, 1982Abstract The molecular forms of proteinase A, proteinase B and Car☐ypeptidase Y, enzymes of the lysosome like yeast vacuole, were studied in mutants ( Wolf,D.H. and Fink,G.R. (1975) J. Bacteriol. 123 , 1150–1156 ; Wolf,D.H. and Ehmann,C. (1978) FEBS Lett. 92 , 121–124 ; Mechler,B. and Wolf,D.H. (1981) Eur. J. Biochem.
Hanne Müller +3 more
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Are Proteinases the Reason for Keratoconus?
Current Eye Research, 2010Keratoconus is a degenerating disease of the eye that results in an irregularly-shaped cornea. The etiology of the disease is unknown and the prognosis is difficult due to the variability in outcome. Keratoconus has been associated with eye rubbing, atopy, contact lens wear, as well as genetic conditions, such as Down's syndrome, Ehlers-Danlos syndrome,
David C. Pye +2 more
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Protein Inhibitors of Proteinases
Annual Review of Biochemistry, 1980PERSPECTIVES AND SUMMARY 593 INTRODUCTION 595 Limited Knowledge 0/ Physiological Function 595 Nomenclature Problems 596 0.2 MACROGLOBULINS 598 INHIBITORS WITH CLASS-SPECIFIC REACTIVE SITES 599 Inhibitors 0/ Carboxyl, Metallo and Sulfhydryl Proteinases 599 Inhibitors 0/ Serine Proteinases 601 The Standard Mechanism 601 The nature of ...
M. Laskowski, I Kato
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