Results 51 to 60 of about 42,007 (249)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

New quality criteria for fresh frozen plasma

Медицинский вестник Юга России, 2019
Objective: development of new quality criteria for fresh frozen plasma. Matherials and methods: at diff erent times of storage of fresh frozen plasma harvested standardly and from the donors aft er Biolan exposure, the parameters of the kallikrein-kinin ...
Elena V. Ryabikina, Elena A. Chernogubova, Yuri V. Shatokhin, Irina V. Snezhko, Olga V. Gerasimova, Elvira E. Kudinova   +5 more
doaj   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Possible role of extracellularly released phagocytic proteinases in the coagulation disorder during liver transplantation [PDF]

, 1991
Orthotopic liver transplantation is frequently associated with a complex coagulation disorder, influencing the outcome of the procedure. In this respect, disseminated intravascular coagulation (DIC) had been suggested to be of causative importance for ...
Blumhardt, G., Himmelreich, G., Jochum, Marianne, Machleidt, W., Neuhaus, P., Riess, H., Roissaint, R.   +6 more
core  

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview

Toxins, 2016
A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors ...
Soichi Takeda
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Characterization of serine proteinase expression in agaricus bisporus and coprinopsis cinerea by using green fluorescent protein and the A. bisporus SPR1 Promoter [PDF]

, 2008
The Agaricus bisporus serine proteinase 1 (SPR1) appears to be significant in both mycelial nutrition and senescence of the fruiting body.
Andy M. Bailey, Andy M. Bailey, Claudine Porta, Claudine Porta, Cunjin Zhang, Cunjin Zhang, Gary D, Gary D. Foster, Kerry S, Kerry S. Burton, Mary N. Heneghan, Mary N. Heneghan, Michael P. Challen, Michael P. Challen   +13 more
core   +4 more sources

Effect of macrophage differentiation and exposure to mildly oxidized LDL on the proteolytic repertoire of THP-1 monocytes

Journal of Lipid Research, 2004
Lipid-laden monocyte/macrophages in atherosclerotic plaques can produce a range of proteinases capable of degrading components of the plaque extracellular matrix, an event that may weaken plaques, rendering them vulnerable to rupture.
Carl Whatling, Hanna Björk, Sara Gredmark, Anders Hamsten, Per Eriksson   +4 more
doaj  

The origin and evolution of plant cystatins and their target cysteine proteinases indicate a complex functional relationship

BMC Evolutionary Biology, 2008
Background Cystatins and their putative targets, the families of cysteine proteinases C1A and C13 play key roles in plants. Comparative genomic analyses are powerful tools to obtain valuable insights into the conservation and evolution of the proteinases
Diaz Isabel, Martinez Manuel
doaj   +1 more source

An Overview of Proteinase Inhibitors [PDF]

Journal of Veterinary Internal Medicine, 1999
Proteinase inhibitors are proteins in the body that regulate the catalytic activity of proteinases. They are important in a large variety of physiologic processes including coagulation, digestion, tumor metastasis and immunity. Proteinase inhibitors are categorized as either nonspecific proteinase inhibitors or class‐specific proteinase inhibitors ...
Kristen Hibbetts, David A. Williams, Brad Hines   +2 more
openaire   +2 more sources