Results 71 to 80 of about 35,571 (308)

Structural characterization of the papaya cysteine proteinases at low pH.

, 2006
Current control of gastrointestinal nematodes relies primarily on the use of synthetic drugs and encounters serious problems of resistance. Oral administration of plant cysteine proteinases, known to be capable of damaging nematode cuticles, has recently
Wintjens, René, Boussard, Paule, Looze, Yvan, Bartik, Kristin, Huet, Joëlle, Raussens, Vincent   +5 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Aislamiento de Candida spp. y otras levaduras en el personal que labora en áreas críticas del Hospital San Juan de Dios Isolation of Candida spp. and other yeasts from Health Care Workers in Critical Care Units of the San Juan de Dios Hospital

Acta Médica Costarricense, 2009
Justificación y objetivos: Los pacientes internados en hospitales, principalmente aquellos que se encuentran severamente enfermos, son más susceptibles a las infecciones por hongos oportunistas, en comparación con la población general.
Pedro Carrillo-Dover, Carolina Álvarez-Vega, Ingrid Salas-Campos, Nury Mora-Brenes   +3 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Role of ADAM and ADAMTS metalloproteinases in airway diseases

Respiratory Research, 2009
Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements.
Noel Agnes, Foidart Jean-Michel, El Hour Mehdi, Hacha Jonathan, Bekaert Sandrine, Quesada-Calvo Florence, Crahay Celine, Gueders Maud M, Rocks Natacha, Paulissen Genevieve, Cataldo Didier D   +10 more
doaj   +1 more source

Protein-Engineered Proteinase of Myeloblastosis Associated Virus, An Enzyme of High Activity and HIV-1 Proteinase-Like Specificity

, 1991
All proteinases of avian and mammalian retroviruses belong to the family of aspartic proteinases, are of similar size and of homologous primary structure; they all act catalytically in the form of highly symmetric molecular dimers.1 Detailed studies of ...
Pichová, I, V. Kostka, M. Andreánsky, Hořejší, M, Konvalinka, J, Fábry, M, P. Štrop, I. Bláha, Velek, J, Sedláček, J, R. Škrabana, Kostka, V, J. Velek, J. Sedláček, Bláha, I, M. Hořejší, Škrabana, R, I. Pichová, S. Foundling, V. Černá, Pavlíčková, L, Foundling, S, J. Konvalinka, Štrop, P, L. Pavlíčková, M. Fábry, Černá, V, Andreánsky, M   +27 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Collagenolytic enzymes from Antarctic hydrobionts: a promising biotechnological approach for accelerating purulent-necrotic wound healing

Український антарктичний журнал
The objective of this study was to isolate the fractions of proteolytic enzymes from Antarctic hydrobionts, specifically Sterechinus neumayeri and Odontaster validus, and assess their wound-healing potential on purulent-necrotic wounds in rats.
Nataliia Raksha, Tetiana Halenova, Tetiana Vovk, Tetiana Koval, Nataliia Nikitina, Liudmyla Stepanova, Tetyana Beregova, Olexiy Savchuk   +7 more
doaj   +1 more source

Analysis of the proteinases of representative Trichomonas vaginalis isolates

, 1990
Isoelectric focusing and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with acrylamide copolymerized with gelatin (substrate-SDS-PAGE) were combined to evaluate the proteinases of both long-term-grown and fresh isolates of ...
Alderete, J F, Neale, K A
core   +1 more source