Results 101 to 110 of about 13,339,631 (403)

Steric constraints in model proteins

, 1997
A simple lattice model for proteins that allows for distinct sizes of the amino acids is presented. The model is found to lead to a significant number of conformations that are the unique ground state of one or more sequences or encodable.
A. Sali, Amos Maritan, C. Branden, C. Chothia, C. J. Camacho, Cristian Micheletti, D. K. Klimov, E. Bornberg-Bauer, F. Seno, Flavio Seno, G. D. Rose, G. N. Ramachandran, H. Li, H. Li, H. S. Chan, H. S. Chan, H. S. Chan, J. Janin, J. M. Deutsch, J. N. Onuchic, J. W. Ponder, Jayanth R. Banavar, K. A. Dill, K. F. Lau, L. A. Mirny, L. Mirny, M. Cieplak, M. H. Hao, M. P. Morrissey, M. R. Betancourt, N. D. Socci, P. D. Thomas, S. J. Hubbard, S. Kirkpatrick, T. E. Creighton   +34 more
core   +1 more source

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data [PDF]

, 2009
Background: Disordered proteins need to be expressed to carry out specified functions; however, their accumulation in the cell can potentially cause major problems through protein misfolding and aggregation.
Edwards, Y.J.K., Jones, D.T., Lobley, A.E., Pentony, M.M.   +3 more
core   +2 more sources

Antagonists of protein–protein interactions [PDF]

Chemistry & Biology, 2000
Protein-protein interactions are often attractive, but not straightforward, targets for disease therapy. Two strategies for identifying inhibitors of these interactions, peptide phage display and high-throughput screening, have recently shown new promise.
openaire   +3 more sources

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Transport of Proteins into Mitochondria [PDF]

, 1980
The mitochondrial ADP/ATP carrier is an integral transmembrane protein of the inner membrane. It is synthesized on cytoplasmic ribosomes. Kinetic data suggested that this protein is transferred into mitochondria in a posttranslational manner.
Allen E. H., Brdiezka D., Chang C. N., Chang C. N., Conboy J. G., Cote C., Date T., Dobberstein B., Flavell R. B., Habermann E., Hackenberg H., Hallermayer G., Harmey M. A., Highfield P. E., Ito K., Klingenberg M., Knoppel E., Korb H., Kreil G., Laemmli U. K., Maccechini M. L., Maccechini M.-L., Mandel G., Marra E., Michel R., Milstein C., Mori M., Nelson N., Pelham H. R. B., Poyton R. O., Poyton R. O., Raymond Y., Schatz G., Sessa G., Shore G. S., Strauss A. W., Vignais P. V., Wickner W., Wickner W., Williams J. C., Zimmermann R., Zimmermann R.   +41 more
core   +1 more source

Protein—protein binding supersites

PLOS Computational Biology, 2019
The lack of a deep understanding of how proteins interact remains an important roadblock in advancing efforts to identify binding partners and uncover the corresponding regulatory mechanisms of the functions they mediate. Understanding protein-protein interactions is also essential for designing specific chemical modifications to develop new reagents ...
Raji Viswanathan, Eduardo Fajardo, Gabriel Steinberg, Matthew Haller, Andras Fiser   +4 more
openaire   +5 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Photophysical Properties of Fluorescent Probe Thioflavin T in Crowded Milieu

Journal of Spectroscopy, 2017
Thioflavin T (ThT) is a widely used fluorescent probe of amyloid fibrils, which accompanies many serious neurodegenerative and other diseases. Until recently, examinations of processes of amyloid fibril formation in vitro were conducted in solutions ...
Natalia P. Rodina, Maksim I. Sulatsky, Anna I. Sulatskaya, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov   +5 more
doaj   +1 more source

Competitive adsorption of plasma proteins at solid—liquid interfaces [PDF]

, 1986
The competitive adsorption of human serum albumin (HSA), human immuno-γ-globulin (HIgG) and human fibrinogen (HFb) onto polystyrene (PS) at 20° C and a pH of 7.35 (phosphate-buffered saline) was studied.
Breemhaar, W., Feijen, J., Lensen, H.G.W., Smolders, C.A.   +3 more
core   +3 more sources