Results 111 to 120 of about 7,997,979 (337)

Selection of specific and efficient siRNAs in new cellular model for Hutchinson-Gilford progeria syndrome therapy

Molecular Therapy: Nucleic Acids
Hutchinson-Gilford progeria syndrome is a fatal genetic disorder caused by a point mutation in the gene encoding the nuclear envelope protein lamin A/C.
Volha Dzianisava, Katarzyna Piekarowicz, Magdalena Machowska, Ryszard Rzepecki   +3 more
doaj   +1 more source

Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy Treatment

Cells, 2019
Hutchinson-Gilford progeria syndrome (HGPS) is one of the most severe disorders among laminopathies—a heterogeneous group of genetic diseases with a molecular background based on mutations in the LMNA gene and genes coding for interacting proteins.
Katarzyna Piekarowicz, Magdalena Machowska, Volha Dzianisava, Ryszard Rzepecki   +3 more
doaj   +1 more source

Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation [PDF]

, 2001
Claire Pecqueur, Marie‐Clotilde Alves‐Guerra, C. Gelly, Corinne Lévi-Meyrueis, Elodie Couplan, Sheila Collins, Daniel Ricquier, Frédéric Bouillaud, Bruno Miroux   +8 more
openalex   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Transfer of proteins into mitochondria [PDF]

, 1983
The precursor form of Neurospora crassa mitochondrial ADP/ATP carrier synthesized in a cell-free protein-synthesizing system can be imported into isolated mitochondria.
Neupert, Walter, Schleyer, Manfred, Zwizinski, Craig   +2 more
core  

Solving the protein sequence metric problem [PDF]

, 2005
William R. Atchley, Jieping Zhao, Andrew D. Fernandes, Tanja Drüke   +3 more
openalex   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Characterization of a novel lipase from Pseudomonas aeruginosa

Nova Biotechnologica et Chimica, 2019
Lipases cleaving oils into fatty acids and glycerol are of great interest for the use in increasing the efficiency of fuels. In this work, a novel lipase from Pseudomonas aeruginosa, P.
Berdiev Nodir Sh., Ziyavitdinov Jamolitdin F., Asrorov Akmal M., Olimjonov Shukhratjon S., Salikhov Shavkat I.   +4 more
doaj   +1 more source

How the global structure of protein interaction networks evolves

, 2002
Two processes can influence the evolution of protein interaction networks: addition and elimination of interactions between proteins, and gene duplications increasing the number of proteins and interactions.
Force A., Force A., Pal C.
core   +2 more sources

Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia [PDF]

, 2016
Jonathan D. Rohrer, Ione Woollacott, Katrina M. Dick, Emilie Brotherhood, Elizabeth Gordón, Alexander D. Fellows, Jamie Toombs, Ronald Druyeh, M. Jorge Cardoso, Sébastien Ourselin, Jennifer M. Nicholas, Niklas Norgren, Simon Mead, Ulf Andréasson, Kaj Blennow, Jonathan M. Schott, Nick C. Fox, Jason D. Warren, Henrik Zetterberg   +18 more
openalex   +1 more source