Results 121 to 130 of about 84,285 (265)

Strength in Weakness: The Mutable Collagenous Tissue of Echinoderms

Encyclopedia
Mutable collagenous tissue (MCT) is a type of connective tissue that is characterized by its capacity to undergo rapid, nervously mediated changes in mechanical properties.
Iain C. Wilkie, M. Daniela Candia Carnevali   +1 more
doaj   +1 more source

Distribution of proteoglycans antigenically related to corneal keratan sulfate proteoglycan [PDF]

, 1987
Three antibodies reacting with corneal keratan sulfate proteoglycan were used to detect antigenically related molecules in 11 bovine and 13 embryonic chick tissues. Two monoclonal antibodies recognized sulfated epitopes on the keratan sulfate chain and a
Caterson, B, Funderburgh, J L, Conrad, G W   +2 more
core  

Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan.

, 2016
Recovery from Toxic-Induced Demyelination Does Not Require the NG2 ...
Marc Ehrlich, Marc Ehrlich (3226734), Stefanie Albrecht, Jacqueline Trotter, Tanja Kuhlmann, Claudia Kemming, Tanja Kuhlmann (377301), Stefanie Albrecht (489274), Claudia Kemming (3226737), Karin Hagemeier (448160), Karin Hagemeier, Jacqueline Trotter (76633)   +11 more
core   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Extracellular matrix remodeling therapeutic strategies to tackle central nervous system diseases

Neural Regeneration Research
Neurodegenerative diseases are a global burden due to the increased life expectancy. Neuroinflammation is not only a result of neurodegeneration but a key player in the initiation and onset of it.
Daniel A. Domingo-Lopez, Maria Rosa Aguilar de Armas, Sergio Martin-Saldaña   +2 more
doaj   +1 more source

Studies of proteoglycan induced arthritis in BALBc mice

, 1989
Studies of proteoglycan-induced arthritis in mice revealed two previously unidentified features: polymorphonuclear leucocytes in knee joint cavities and sacroiliac joint involvement.
Mathai, Lalitha
core  

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Proteoglycans in Prostate Cancer Progression and Therapy Resistance

Medicina
The extracellular matrix (ECM) is a complex noncellular network of (macro-)molecules that surrounds and supports diverse cells in tissues and organs.
Ivana Samaržija
doaj   +1 more source

Xenopus Laevis Chondroitin sulfate proteoglycan 2 (Versican) variant V2a mRNA complete cds, alternatively spliced

, 2007
Direct submissionDirect submissionGeneBank database EU204648,large extracellular proteoglycan; alternatively ...
CASINI P, MATTINA W, D'ASCOLA, ANGELA, CALATRONI, Alberto, TRAINA, PAOLA, NASTASI G, NARDI I, CAMPO, Salvatore Giuseppe, ORI M, CAMPO, Giuseppe Maurizio, AVENOSO, Angela   +10 more
core  

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source