Results 311 to 320 of about 130,074 (337)
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Proteoglycans in amyloidogenesis
Neurobiology of Aging, 1989The potentially important role of proteoglycans and glycosaminoglycans in the modern concept of general amyloidogenesis has been discussed.
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Evidence of proteoglycan/proteoglycan interactions within aggregates
Journal of Orthopaedic Research, 1991AbstractNonaggregated proteoglycan monomers, digested fragments of the monomers, as well as link proteins have been shown to self‐associate. These associations have not been shown to occur on the aggregate. However, previous reports, using the Kleinschmidt technique of monolayer electron microscopy, have noted proteoglycan subunits on the aggregate ...
Randall W. Viola +3 more
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Interaction of bone proteoglycans and proteoglycan components with hydroxyapatite
Biochimica et Biophysica Acta (BBA) - General Subjects, 2001The small leucine-rich proteoglycans (SLRPs) of bone interact with hydroxyapatite (HAP) and are proposed to play an important role in the regulation of the mineralisation process. The present study has examined the interaction of bone SLRPs, purified, liberated bone glycosaminoglycan (GAG) chains and core proteins, as well as commercial chondroitin 4 ...
Diana T Hughes Wassell +3 more
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Emerging proteoglycans and proteoglycan-targeted therapies in rheumatoid arthritis
American Journal of Physiology-Cell Physiology, 2022Rheumatoid arthritis (RA) is a common autoimmune disease that causes inflammation of the joints and damage to the cartilage and bone. The pathogenesis of RA is characterized in many patients by the presence of antibodies against citrullinated proteins.
Brianna Hurysz, Nunzio Bottini
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Bulletin of Experimental Biology and Medicine, 1996
Studies of proteoglycans for their capacity to perform the function of steric exclusion of cells are reviewed. The ability of the proteoglycans hyaluronic acid and protein-chrondroitinkeratosulfate and their aggregates to effect cell aggregation and steric exclusion is determined by the structure of glycosaminoglycan components and the amount of ...
S. A. Kuz'mina, S. M. Bychkov
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Studies of proteoglycans for their capacity to perform the function of steric exclusion of cells are reviewed. The ability of the proteoglycans hyaluronic acid and protein-chrondroitinkeratosulfate and their aggregates to effect cell aggregation and steric exclusion is determined by the structure of glycosaminoglycan components and the amount of ...
S. A. Kuz'mina, S. M. Bychkov
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1994
Cytokines play an important regulatory role in the metabolism of proteoglycans. Proteoglycans are found in plasma membranes, but predominantly in the extra-cellular matrix. In the latter they are quantitatively and qualitatively essential components. Especially in a tissue like cartilage without any blood vessels, the cells are dependent on cytokines ...
Bÿlsma Jw, Huber-Bruning O, Nietfeld Jj
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Cytokines play an important regulatory role in the metabolism of proteoglycans. Proteoglycans are found in plasma membranes, but predominantly in the extra-cellular matrix. In the latter they are quantitatively and qualitatively essential components. Especially in a tissue like cartilage without any blood vessels, the cells are dependent on cytokines ...
Bÿlsma Jw, Huber-Bruning O, Nietfeld Jj
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The Immunology of Proteoglycans
Connective Tissue Research, 1982This discussion will touch on some of the central features of proteoglycan (PG) immunology and suggest that despite the recent introduction of very sophisticated immunochemical techniques, this remains a problematic field. As I shall indicate, there are difficulties in understanding the immunological properties of PGs which are due to the nature of PG,
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CANCER AND METASTASIS REVIEW, 1988
There is a growing realization that the whole tumor cell-matrix complex must be investigated in order to fully understand the process of cancer growth and metastasis. Proteoglycans are intrinsic constituents of the cell surface, extracellular matrix, and basement membrane, three logistically and functionally important structures involved in most ...
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There is a growing realization that the whole tumor cell-matrix complex must be investigated in order to fully understand the process of cancer growth and metastasis. Proteoglycans are intrinsic constituents of the cell surface, extracellular matrix, and basement membrane, three logistically and functionally important structures involved in most ...
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Developmental Neuroscience, 1989
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Renée K. Margolis +3 more
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Renée K. Margolis +3 more
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Proteoglycan Isolation and Analysis
Current Protocols in Cell Biology, 2000AbstractProteoglycans can be difficult molecules to isolate and analyze due to large mass, charge, and tendency to aggregate or form macromolecular complexes. This unit describes detailed methods for purification of matrix, cell surface, and cytoskeleton‐linked proteoglycans.
Woods, Anne, Couchman, John R.
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