Results 211 to 220 of about 132,430 (262)
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Experientia, 1993
In this review the structure and functions of two non-related proteoglycan families are discussed. One family represents a group of extracellular matrix macromolecules characterized by core proteins with leucine-rich repeat motifs. Within this family special attention is given to those members which carry chondroitin or dermatan sulfate ...
Elke Schönherr +2 more
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In this review the structure and functions of two non-related proteoglycan families are discussed. One family represents a group of extracellular matrix macromolecules characterized by core proteins with leucine-rich repeat motifs. Within this family special attention is given to those members which carry chondroitin or dermatan sulfate ...
Elke Schönherr +2 more
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Progress in Retinal and Eye Research, 2002
In this article, we summarize the roles of proteoglycans in retinal tissue. Chondroitin sulfate and heparan sulfate proteoglycans are the major constituents in proteoglycans expressed in retinal tissue. Soluble heparan sulfate proteoglycans are found in the extracellular matrices of the basement membrane, such as the inner limiting membrane and Bruch's
Hidenobu Tanihara, Masaru Inatani
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In this article, we summarize the roles of proteoglycans in retinal tissue. Chondroitin sulfate and heparan sulfate proteoglycans are the major constituents in proteoglycans expressed in retinal tissue. Soluble heparan sulfate proteoglycans are found in the extracellular matrices of the basement membrane, such as the inner limiting membrane and Bruch's
Hidenobu Tanihara, Masaru Inatani
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Cornea, 2002
Various proteoglycans are expressed in ocular tissues. We investigated and reviewed the distribution and the potential roles of proteoglycans in cornea, trabecular meshwork, and retinal tissues.Immunohistochemical studies were performed in rat ocular tissues. The concentration of transforming growth factor (TGF)-beta2, which regulates the expression of
Hidenobu Tanihara +4 more
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Various proteoglycans are expressed in ocular tissues. We investigated and reviewed the distribution and the potential roles of proteoglycans in cornea, trabecular meshwork, and retinal tissues.Immunohistochemical studies were performed in rat ocular tissues. The concentration of transforming growth factor (TGF)-beta2, which regulates the expression of
Hidenobu Tanihara +4 more
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Proteoglycans in Dentinogenesis
Critical Reviews in Oral Biology & Medicine, 2001The predominant proteoglycans present in predentin and dentin are the chondroitin-sulphate-rich decorin and biglycan and the keratan-sulphate-rich lumican and fibromodulin. These are small, interstitial, leucine-rich proteoglycans which have recently been shown to exist in gradients across the predentin.
Graham Embery +4 more
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Proteoglycans in amyloidogenesis
Neurobiology of Aging, 1989The potentially important role of proteoglycans and glycosaminoglycans in the modern concept of general amyloidogenesis has been discussed.
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Radioimmunoassay of Proteoglycans
Journal of Immunoassay, 1984Human articular cartilage proteoglycan monomers (PG) were purified and used for developing a radioimmunoassay. Its analytical sensitivity is 0.6 ng/tube and its clinical sensitivity is 20 microliter/tube for serum and 0.12 microliter/tube for synovial fluid.
P. Gysen, Paul Franchimont
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Current Pharmaceutical Design, 2017
Most proteoglycans are heterogeneous molecules composed of a protein core with glycosaminoglycans (GAGs) attached. GAGs are highly negatively charged molecules that readily bind to enzymes, growth factors, cytokines etc. and as such have many functions.
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Most proteoglycans are heterogeneous molecules composed of a protein core with glycosaminoglycans (GAGs) attached. GAGs are highly negatively charged molecules that readily bind to enzymes, growth factors, cytokines etc. and as such have many functions.
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Evidence of proteoglycan/proteoglycan interactions within aggregates
Journal of Orthopaedic Research, 1991AbstractNonaggregated proteoglycan monomers, digested fragments of the monomers, as well as link proteins have been shown to selfâassociate. These associations have not been shown to occur on the aggregate. However, previous reports, using the Kleinschmidt technique of monolayer electron microscopy, have noted proteoglycan subunits on the aggregate ...
Randall W. Viola +3 more
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Interaction of bone proteoglycans and proteoglycan components with hydroxyapatite
Biochimica et Biophysica Acta (BBA) - General Subjects, 2001The small leucine-rich proteoglycans (SLRPs) of bone interact with hydroxyapatite (HAP) and are proposed to play an important role in the regulation of the mineralisation process. The present study has examined the interaction of bone SLRPs, purified, liberated bone glycosaminoglycan (GAG) chains and core proteins, as well as commercial chondroitin 4 ...
Diana T Hughes Wassell +3 more
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Emerging proteoglycans and proteoglycan-targeted therapies in rheumatoid arthritis
American Journal of Physiology-Cell Physiology, 2022Rheumatoid arthritis (RA) is a common autoimmune disease that causes inflammation of the joints and damage to the cartilage and bone. The pathogenesis of RA is characterized in many patients by the presence of antibodies against citrullinated proteins.
Brianna Hurysz, Nunzio Bottini
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