Results 281 to 290 of about 156,238 (329)

Heart‐On‐a‐Chip with Integrated Ultrasoft Mechanosensors for Continuous Measurement of Cell‐ and Tissue‐Scale Contractile Stresses

Small, EarlyView.
We present a heart‐on‐a‐chip platform embedded with ultrasoft mechanosensors for real‐time, multi‐scale stress mapping in engineered cardiac tissues. The system enables simultaneous quantification of local cell‐generated stresses and global tissue contractile forces.
Ali Mousavi, Christina‐Marie Boghdady, Shihao Cui, Sabra Rostami, Amid Shakeri, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Milica Radisic, Christopher Moraes, Houman Savoji   +10 more
wiley   +1 more source

Humanized Bone Model Identifies BMP6 as a Multifunctional Regulator in Myeloma Bone Disease. [PDF]

Biomolecules
Wang J, Baardemans T, de Matos Simoes R, Noort W, Ruiter RWJ, Prins HJ, van Hal-van Veen SE, Yuan H, de Bruijn JD, Martens ACM, Mitsiades CS, Zweegman S, Themeli M, Groen RWJ.   +13 more
europepmc   +1 more source

Step‐Ladder Bioprinting to Align Collagen Fibers for Anisotropic Tissue Fabrication

Small, EarlyView.
The step‐ladder printing platform includes successive segments of channels with varying widths in a custom barrel design. This design allows for improved anisotropy of collagen fibers during extrusion. To demonstrate its effectiveness, corneal constructs with high transparency and shape fidelity, as well as articular cartilage constructs, displaying ...
Ilayda Namli, Yogendra Pratap Singh, Deepak Gupta, Syed Hasan Askari Rizvi, Yasar Ozer Yilmaz, Joao Vitor Silva Robazzi, Medine Dogan Sarikaya, Mehmet Baykara, Ibrahim T. Ozbolat   +8 more
wiley   +1 more source

Normalizing the Tumor Microenvironment: A New Frontier in Ovarian Cancer Therapy. [PDF]

Int J Mol Sci
Jones AP, Zhao Y, Rueda BR, Yeku OO, Xu L.   +4 more
europepmc   +1 more source

Renovating Neural Networks With Viral‐Mediated Gene Transfer From A Tissue Contacting Matrix Mimic

Small, EarlyView.
Fmoc‐DDIKVAV self‐assembling peptidemediated delivery of AAV‐BDNF significantly enhances neuroprotection in the striatum of a mouse model compared with AAV‐BDNF injection alone. This synergistic integration of biomaterial scaffolding and gene therapy holds substantial promise for slowing the progression of neurodegenerative diseases such as Huntington ...
Shiva Soltani Dehnavi, Negar Mahmoudi, Yi Wang, Samuel Cheeseman, Rita Ferreira, Ross D. Hannan, Leszek Lisowski, Vincent S. J. Craig, Niamh Moriarty, Clare L. Parish, Richard J. Williams, David R. Nisbet   +11 more
wiley   +1 more source

Response to "Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway". [PDF]

Invest Ophthalmol Vis Sci
Karimi A, Kelley M, Acott T.
europepmc   +1 more source

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

, 1988
Alan D. Snow, H Mar, David Nochlin, Koji Kimata, Masato Kato, S Suzuki, John M. Hassell, Thomas N. Wight   +7 more
openalex   +1 more source

Thermo‐Chemically Modified Silk Scaffolds Reveal Niche‐Driven Regulation of Hematopoiesis and Fibrosis

Small, EarlyView.
We introduce a versatile 3D platform that recreates key physical and biological features of the human bone marrow. By integrating tunable silk biomaterials, stromal cells, and human hematopoietic progenitors, the model captures both healthy and diseased microenvironments, analysis of blood formation, and its disruption in pathological conditions ...
Christian A. Di Buduo, Carolina P. Miguel, Giulia Della Rosa, Vittorio Abbonante, Santo Diprima, Delfina Tosi, Marta Filibian, Daniele Cattaneo, Jugal Kishore Sahoo, Nicola Tirelli, Alessandra Iurlo, Umberto Gianelli, David L. Kaplan, Alessandra Balduini   +13 more
wiley   +1 more source

The role of chondroitin sulfate in venous thrombosis, organization, and resolution. [PDF]

Am J Physiol Heart Circ Physiol
Lamenza FF, Kessinger CW.
europepmc   +1 more source

Cardenolide‐Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non‐small Cell Lung Cancer Cells

Small Methods, EarlyView.
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner, Anika Mifka, Rodrigo Maia de Pádua, Izabella Thaís da Silva, Iara Zanella Guterres, Lorenzo Sana, Gregor Fuhrmann, Jennifer Munkert   +7 more
wiley   +1 more source