Regional FDL tendon properties are regulated by biglycan in a collagen VI-independent manner [PDF]
Matrix Biology PlusHealthy tendon is associated with organized and aligned extracellular matrix (ECM) that becomes disorganized with disease, yet the mechanisms and pathogenesis of tendon disease remain poorly understood.
R.J. Leiphart +3 more
doaj +2 more sources
Biglycan Regulates MG63 Osteosarcoma Cell Growth Through a LPR6/β-Catenin/IGFR-IR Signaling Axis
Frontiers in Oncology, 2018 Biglycan, a small leucine rich proteoglycan (SLRP), is an important participant in bone homeostasis and development as well as in bone pathology. In the present study biglycan was identified as a positive regulator of MG63 osteosarcoma cell growth (p ≤ 0.
Aikaterini Berdiaki +2 more
exaly +3 more sources
Serum decorin and biglycan levels as predictive biomarkers for lung fibrosis severity and mortality risk in COVID-19 patients [PDF]
Frontiers in MedicineIntroductionIndividuals experiencing severe symptoms of COVID-19 are at the greatest risk of developing post-COVID lung fibrosis, which significantly impacts long-term health outcomes.
Shaaf Ahmad +3 more
doaj +2 more sources
Could the Phenotypic Outcomes of Genetic Variability in Cells Operating in Mechanically Dynamic Environments be Influenced by a Disrupted "Cell-ECM" Relationship? Using Cystic Fibrosis and Marfan Syndrome as an Example. [PDF]
BioessaysThe “Cell‐Extracellular Matrix Unit” in a mechanically active environment (Centre). Mutations in ECM molecules such as fibrillin‐1 can lead to Marfan Syndrome (A), while mutations in the cellular CFTR can lead to Cystic Fibrosis (B). A combination of such mutations without a clinical phenotype alone could also lead to disease (C). ABSTRACT Diseases due
Hart DA.
europepmc +2 more sources
Analysing the bioactive makeup of demineralised dentine matrix on bone marrow mesenchymal stem cells for enhanced bone repair [PDF]
European Cells & Materials, 2017 Dentine matrix has proposed roles for directing mineralised tissue repair in dentine and bone; however, the range of bioactive components in dentine and specific biological effects on bone-derived mesenchymal stem cells (MSCs) in humans are less well ...
SJ Avery +3 more
doaj +6 more sources
The skeletal phenotype of chondroadherin deficient mice [PDF]
, 2013 Chondroadherin, a leucine rich repeat extracellular matrix protein with functions in cell to matrix interactions, binds cells via their a2b1 integrin as well as via cell surface proteoglycans, providing for different sets of signals to the cell ...
A Franzen +44 more
core +13 more sources
Matrix Biology Plus, 2022 Tendon is a vital musculoskeletal tissue that is prone to degeneration. Proper tendon maintenance requires complex interactions between extracellular matrix components that remain poorly understood.
Ryan J. Leiphart +10 more
doaj +1 more source
Inhibitory role of the small leucine-rich proteoglycan biglycan in bladder cancer. [PDF]
PLoS ONE, 2013 Urothelial bladder cancer is the ninth most common cancer. Despite surgical and chemotherapeutic treatment the prognosis is still poor once bladder cancer progresses to a muscle-invasive state.
Christian Niedworok +9 more
doaj +1 more source
IPSC reprogramming of two patients with spondyloepimetaphyseal dysplasia (SEMD, biglycan type)
Stem Cell Research, 2023 Hemizygous missense variants in the X-linked BGN gene, encoding the extracellular matrix protein biglycan, cause spondyloepimetaphyseal dysplasia (SEMD, biglycan type), which is clinically characterized by short stature, brachydactyly and osteoarthritis.
Pauline De Kinderen +7 more
doaj +1 more source
Biglycan deletion alters adiponectin expression in murine adipose tissue and 3T3-L1 adipocytes. [PDF]
PLoS ONE, 2012 Obesity promotes increased secretion of a number of inflammatory factors from adipose tissue. These factors include cytokines and very lately, extracellular matrix components (ECM). Biglycan, a small leucine rich proteoglycan ECM protein, is up-regulated
Meliza G Ward, Kolapo M Ajuwon
doaj +1 more source