Results 21 to 30 of about 8,243 (205)

Catabolism of aggrecan, decorin and biglycan in tendon [PDF]

Biochemical Journal, 2000
We have examined the catabolism of the proteoglycans aggrecan, decorin and biglycan in fresh tendon samples and in explant cultures of tissue from the tensional and compressed regions of young and mature bovine tendons. A panel of well-characterized antibodies that recognize glycosaminoglycan or protein (linear or neoepitope) sequences was used to ...
S G, Rees, C R, Flannery, C B, Little, C E, Hughes, B, Caterson, C M, Dent   +5 more
openaire   +4 more sources

Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy

Breast Cancer Research, 2021
Background Biglycan is a proteoglycan found in the extracellular matrix. We have previously shown that biglycan is secreted from tumor endothelial cells and induces tumor angiogenesis and metastasis.
Li Cong, Nako Maishi, Dorcas A. Annan, Marian F. Young, Hirofumi Morimoto, Masahiro Morimoto, Jin-Min Nam, Yasuhiro Hida, Kyoko Hida   +8 more
doaj   +1 more source

Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. [PDF]

PLoS ONE, 2012
Cesarean birth rates are rising. Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of ...
Zhiping Wu, Abraham W Aron, Elyse E Macksoud, Renato V Iozzo, Chi-Ming Hai, Beatrice E Lechner   +5 more
doaj   +1 more source

Transcriptional Regulation of the Human Biglycan Gene [PDF]

Journal of Biological Chemistry, 1996
The small leucine-rich proteoglycan biglycan is involved in several physiological and pathophysiological processes through the ability of its core protein to interact with other extracellular matrix molecules and transforming growth factor-beta (TGF-beta).
H, Ungefroren, N B, Krull
openaire   +2 more sources

Breast cancer dataset with biomarker Biglycan

Data in Brief, 2023
تتكون مجموعة البيانات هذه من صور مجهرية للتعبير الكيميائي المناعي للبيغليكان (BGN) في أنسجة الثدي، مع السرطان وبدونه، باستخدام فقط تلطيخ 3-3'diaminobenzidine (DAB)، بعد معالجة الصور باستخدام مكون إضافي لإزالة الالتفاف اللوني، من Image J. تم الحصول على تعبير DAB الكيميائي المناعي للبيغليكان (BGN) باستخدام الجسم المضاد أحادي النسيلة (M01) (استنساخ 4E1 ...
Pedro Clarindo da Silva Neto, Rafael Kunst, Jorge Luís Victória Barbosa, Ana Paula Thiesen Leindecker, Ricardo Francalacci Savaris   +4 more
openaire   +3 more sources

Expression, localization and synthesis of small leucine-rich proteoglycans in developing mouse molar tooth germ

European Journal of Histochemistry, 2020
The gene expression and protein synthesis of small leucine-rich proteoglycans (SLRPs), including decorin, biglycan, fibromodulin, and lumican, was analyzed in the context of the hypothesis that they are closely related to tooth formation.
Angammana Randilini, Kaoru Fujikawa, Shunichi Shibata   +2 more
doaj   +1 more source

Interaction of Biglycan with Type I Collagen [PDF]

Journal of Biological Chemistry, 1995
The small proteoglycan decorin is known to interact with type I collagen fibrils, thereby influencing the kinetics of fibril formation and the distance between adjacent collagen fibrils. The structurally related proteoglycan biglycan has been proposed not to bind to fibrillar collagens.
E, Schönherr, P, Witsch-Prehm, B, Harrach, H, Robenek, J, Rauterberg, H, Kresse   +5 more
openaire   +2 more sources

WISP-1 Binds to Decorin and Biglycan [PDF]

Journal of Biological Chemistry, 2001
Wnt-1-induced secreted protein 1 (WISP-1) is a member of the CCN (connective tissue growth factor, Cyr61, NOV) family of growth factors. Structural and experimental evidence suggests that CCN family member activities are modulated by their interaction with sulfated glycoconjugates.
L, Desnoyers, D, Arnott, D, Pennica
openaire   +2 more sources

Identification, characterization and expression analysis of biglycan in asian elephant (elephas maximus) [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017
The aims of this study were to investigate the coding sequence and the deduced amino acid sequence of Asian elephant"s biglycan gene as well as its expression in different tissues and conditions using wound healing as a model.
Siriwadee CHOMDEJ, Waraluk SAOKEAW, Kittisak BUDDHACHAT, Waranee PRADIT, Puntita SIENGDEE, Sittidet MAHASAWANGKUL, Supaphen SRIPIBOON, Chalermchart SOMGIRD, Korakot NGANVONGPANIT, Siriwan ONGCHAI, Chatchote THITARAM   +10 more
doaj   +1 more source

Biglycan- and sphingosine kinase-1 signaling crosstalk regulates the synthesis of macrophage chemoattractants [PDF]

, 2017
In its soluble form, the extracellular matrix proteoglycan biglycan triggers the synthesis of the macrophage chemoattractants, chemokine (C-C motif) ligand CCL2 and CCL5 through selective utilization of Toll-like receptors (TLRs) and their adaptor ...
Malgorzata Wygrecka, Brandes, Ralf, Schäfer, Liliana, Liliana Schaefer, Huwiler, Andrea, Brandes, Ralf P, Schaefer, Liliana, Tredup, Claudia, Hsieh, Louise Tzung-Harn, Năstase, Mădălina-Viviana, Pfeilschifter, Josef, Ralf Brandes, Andrea Huwiler, Fork, Christian, Roedig, Heiko, Rödig, Heiko, Louise Hsieh, Heiko Roedig, Christian Fork, Jinyang Zeng-Brouwers, Schwalm, Stephanie, Chiara Poluzzi, Stephanie Schwalm, Claudia Tredup, Wygrecka, Malgorzata, Josef Pfeilschifter, Zeng-Brouwers, Jinyang, Madalina-Viviana Nastase, Poluzzi, Chiara   +28 more
core   +1 more source