Results 31 to 40 of about 8,243 (205)
Frontiers in Immunology, 2021 Primary Sjögren’s syndrome is an autoimmune disease that is predominantly seen in women. The disease is characterized by exocrine gland dysfunction in combination with serious systemic manifestations.
Jeremy Kiripolsky +7 more
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Science-Business eXchange, 2011 Tivorsan Pharmaceuticals is working with a Brown University team to optimize recombinant biglycan for delivery to patients with Duchenne muscular dystrophy. The work builds on the researchers' finding that the extracellular matrix glycoprotein decreases muscle pathology and improves muscle function in dystrophic mice.
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Different Usage of the Glycosaminoglycan Attachment Sites of Biglycan [PDF]
Journal of Biological Chemistry, 2001 Biglycan is a member of the small leucine-rich proteoglycan family. Its core protein comprises two chondroitin/dermatan sulfate attachment sites on serine 42 and serine 47, respectively, which are the fifth and tenth amino acid residues, respectively, after removal of the prepro peptide. Because the regulation of glycosaminoglycan chain assembly is not
H, Kresse +6 more
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Expression and the Prognostic Value of Biglycan in Gastric Cancer
Computational and Mathematical Methods in Medicine, 2022 Background. Biglycan (BGN) is a family member of small leucine-rich repeat proteoglycans. High expression of BGN might enhance the invasion and metastasis in some types of tumors. Here, the prognostic significance of BGN was evaluated in gastric cancer. Material and Methods.
Sizhe Hu +3 more
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Cell Reports, 2020 Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity.
Chang Yeop Han +15 more
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The Tendon Injury Response is Influenced by Decorin and Biglycan [PDF]
Annals of Biomedical Engineering, 2013 Defining the constituent regulatory molecules in tendon is critical to understanding the process of tendon repair and instructive to the development of novel treatment modalities. The purpose of this study is to define the structural, expressional, and mechanical changes in the tendon injury response, and elucidate the roles of two class I small ...
Dunkman, Andrew A +11 more
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Journal of Lipid Research, 2017 Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan.
Patricia G. Wilson +4 more
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Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer
Thoracic Cancer, 2021 Objectives In lung cancer, surgery remains the most curative treatment and limited resection is beneficial for patients with low cardiopulmonary function and low malignancy tumors.
Hirofumi Morimoto +9 more
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Acta Biochimica et Biophysica Sinica, 2021 Hedgehog (Hh) signalling plays essential roles in regulating embryonic development and contributes to tumour initiation, growth and progression in multiple cancers.
Zeng Shaopeng +8 more
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Journal of Lipid Research, 2002 Retention of apolipoprotein (apo)B and apoE-containing lipoproteins by extracellular vascular proteoglycans is critical in atherogenesis. Moreover, high circulating apoC-III levels are associated with increased atherosclerosis risk.
Katherine Olin-Lewis +6 more
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