Results 31 to 40 of about 13,898 (220)

Biglycan Modulates Osteoblast Differentiation and Matrix Mineralization [PDF]

Journal of Bone and Mineral Research, 2005
Abstract MC3T3-E1 cell-derived clones expressing higher (S) or lower (AS) levels of biglycan were generated and characterized. The processes of cell differentiation and matrix mineralization were accelerated in S but delayed in AS, indicating that BGN modulates osteoblastic cell differentiation. Introduction: Biglycan (BGN)
Duenpim, Parisuthiman, Yoshiyuki, Mochida, Wagner R, Duarte, Mitsuo, Yamauchi   +3 more
openaire   +2 more sources

Immune-Intrinsic Myd88 Directs the Production of Antibodies With Specificity for Extracellular Matrix Components in Primary Sjögren’s Syndrome

Frontiers in Immunology, 2021
Primary Sjögren’s syndrome is an autoimmune disease that is predominantly seen in women. The disease is characterized by exocrine gland dysfunction in combination with serious systemic manifestations.
Jeremy Kiripolsky, Eileen M. Kasperek, Chengsong Zhu, Quan-Zhen Li, Jia Wang, Guan Yu, Jill M. Kramer, Jill M. Kramer   +7 more
doaj   +1 more source

The pathogenesis of tendinopathy. A molecular perspective [PDF]

, 2004
There are many publications that discuss the aetiology, diagnosis and treatment of the various forms of tendinopathy, but few are based on conclusive scientific evidence.
Riley, GP
core   +1 more source

Interaction of Biglycan with Type I Collagen [PDF]

Journal of Biological Chemistry, 1995
The small proteoglycan decorin is known to interact with type I collagen fibrils, thereby influencing the kinetics of fibril formation and the distance between adjacent collagen fibrils. The structurally related proteoglycan biglycan has been proposed not to bind to fibrillar collagens.
E, Schönherr, P, Witsch-Prehm, B, Harrach, H, Robenek, J, Rauterberg, H, Kresse   +5 more
openaire   +2 more sources

Tendinopathy—from basic science to treatment [PDF]

, 2008
Chronic tendon pathology (tendinopathy), although common, is difficult to treat. Tendons possess a highly organized fibrillar matrix, consisting of type I collagen and various 'minor' collagens, proteoglycans and glycoproteins.
A McCormick, AH Drummond, AJ Banes, AN Bamji, AN Corps, AN Corps, AN Corps, AP D'Vaz, B Pasternak, BL Woodley, BM Clancy, CA Speed, D Bjur, EM Badley, G Puddu, G Riley, GAC Murrell, GC Jones, GC Jones, GP Riley, GP Riley, Graham Riley, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Langberg, H Langberg, H Langberg, H Nagase, HA Awad, J Archambault, JA Paoloni, JA Paoloni, JA Paoloni, JD Rompe, JE Carpenter, JL Cook, JM Archambault, L Józsa, L Ohberg, LC Almekinders, LJ McCawley, M Aström, M Benjamin, M Gotoh, M Gotoh, M Lavagnino, M Lavagnino, MD Chard, ME Jones, MH Khan, N Mafi, P Burssens, P Kannus, R Salingcarnboriboon, RA Bank, RF Ker, RK Smith, SA Fenwick, SC Fu, SG Rees, SP Arnoczky, T Pufe, T Pufe, T Samiric, TG Gerich, TW Ehlers, UM Wewer   +69 more
core   +1 more source

Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity

Cell Reports, 2020
Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity.
Chang Yeop Han, Inkyung Kang, Ingrid A. Harten, John A. Gebe, Christina K. Chan, Mohamed Omer, Kimberly M. Alonge, Laura J. den Hartigh, Diego Gomes Kjerulf, Leela Goodspeed, Savitha Subramanian, Shari Wang, Francis Kim, David E. Birk, Thomas N. Wight, Alan Chait   +15 more
doaj   +1 more source

Review: Dystroglycan in the Nervous System [PDF]

, 2007
Dystroglycan is part of a large complex of proteins, the dystrophin-glycoprotein complex, which has been implicated in the pathogenesis of muscular dystrophies for a long time.
Matthias Samwald
core   +2 more sources

Recombinant Biglycan Promotes Bone Morphogenetic Protein-induced Osteogenesis [PDF]

Journal of Dental Research, 2014
The aim of this study was to determine the effects of glutathione-S-transferase-fused recombinant biglycan (GST-BGN) on craniofacial bone regeneration. We recently demonstrated a positive effect of tissue-derived BGN on bone morphogenetic protein 2 (BMP-2) function, which is exerted likely via the BGN core protein. Here, we investigated the effects of
P A, Miguez, M, Terajima, H, Nagaoka, J A R, Ferreira, K, Braswell, C C, Ko, M, Yamauchi   +6 more
openaire   +2 more sources

Borrelia burgdorferi Infection in Biglycan Knockout Mice

The Journal of Infectious Diseases, 2019
Borrelia burgdorferi sensu lato spirochetes (Borrelia) causing Lyme borreliosis are able to disseminate from the initial entry site to distant organs in the host. Outer-surface adhesins are crucial in the bacterial dissemination and adhesion to various tissues.
Pietikäinen Annukka, Liljenbäck Heidi, Salo Jemiina, Hytönen Jukka, Cuellar Julia, Söderström Mirvamaaria, Glader Otto, Hurme Saija   +7 more
openaire   +4 more sources

Catabolism of aggrecan, decorin and biglycan in tendon [PDF]

Biochemical Journal, 2000
We have examined the catabolism of the proteoglycans aggrecan, decorin and biglycan in fresh tendon samples and in explant cultures of tissue from the tensional and compressed regions of young and mature bovine tendons. A panel of well-characterized antibodies that recognize glycosaminoglycan or protein (linear or neoepitope) sequences was used to ...
S G, Rees, C R, Flannery, C B, Little, C E, Hughes, B, Caterson, C M, Dent   +5 more
openaire   +2 more sources