Results 51 to 60 of about 13,898 (220)
OncoImmunology, 2022 Cancer-associated fibroblasts (CAFs) are essential for tumor microenvironment remodeling and correlate with tumor progression. However, interactions between CAFs and tumor cells and immune cells in triple-negative breast cancer (TNBC) are still poorly ...
Shaoquan Zheng +12 more
doaj +1 more source
Biomolecules, 2023 The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation.
Paul Dowling +4 more
doaj +1 more source
Compensatory fetal membrane mechanisms between biglycan and decorin in inflammation. [PDF]
, 2015 Preterm premature rupture of fetal membranes (PPROM) is associated with infection, and is one of the most common causes of preterm birth. Abnormal expression of biglycan and decorin, two extracellular matrix proteoglycans, leads to preterm birth and ...
Aron, Abraham +4 more
core +2 more sources
Journal of Inflammation, 2012 Background Inflammation in adipose tissue (AT) during obesity causes impaired AT function. Although multiple extracellular matrix (ECM) proteins are expressed in AT their potential role in adipose tissue inflammation is unclear.
Adapala Venkata J +2 more
doaj +1 more source
Experimental rat models of chronic allograft nephropathy: a review [PDF]
, 2014 Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT
Haylor, John, Shrestha, Badri
core +2 more sources
Biglycan gene expression in UVR‐exposed rabbit corneas [PDF]
Acta Ophthalmologica Scandinavica, 2004 Abstract.Purpose: It is known that stromal proteoglycans play an important role in the hydration and transparency of the mammalian cornea. Proteoglycans have been described as a pathological deposit in climatic proteoglycan stromal keratopathy, which is associated with chronic ultraviolet radiation (UVR) exposure.
Alexander, Podskochy +3 more
openaire +2 more sources
Biglycan promotes proliferation and metastasis of ovarian cancer. [PDF]
Int J Clin Exp PatholOvarian cancer (OC) is a significant threat to the health of women. Biglycan (BGN) plays a crucial role in the oncogenesis and progression of various human cancers. The aim of this study was to clarify the role of BGN in OC.Immunohistochemical analysis was performed to detect BGN levels in the OC tissues of 68 patients who underwent cytoreductive ...
Fang SY, Zhang XM, Chen XP.
europepmc +3 more sources
DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown [PDF]
, 2011 Damage-associated molecular patterns (DAMPs) or cell death associated molecular patterns (CDAMPs) are a subset of endogenous intracellular molecules that are normally hidden within living cells but become either passively released by primary and ...
Agostinis, Patrizia +3 more
core +1 more source
Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction [PDF]
Circulation, 2008 Background— After myocardial infarction (MI), extensive remodeling of extracellular matrix contributes to scar formation and preservation of hemodynamic function. On the other hand, adverse and excessive extracellular matrix remodeling leads to fibrosis and impaired function.
Westermann, D. +19 more
openaire +3 more sources
Tumour necrosis factor‐α interacts with biglycan and decorin [PDF]
FEBS Letters, 2002 Several interactions of cytokines with extracellular matrix molecules are mediated by proteoglycans, such as biglycan and decorin. Using surface plasmon resonance, we show for the first time that tumour necrosis factor‐α (TNF‐α) binds to both biglycan and decorin with K ds of 0.81 μM and 1.23 μM respectively, a binding that was confirmed by Scatchard ...
Tufvesson, Ellen +1 more
openaire +2 more sources