Results 71 to 80 of about 7,104 (177)

The Proteoglycans Biglycan and Decorin Protect Cardiac Cells against Irradiation-Induced Cell Death by Inhibiting Apoptosis

Cells
Radiation-induced heart disease (RIHD), a common side effect of chest irradiation, is a primary cause of mortality among patients surviving thoracic cancer. Thus, the development of novel, clinically applicable cardioprotective agents which can alleviate
Renáta Gáspár, Petra Diószegi, Dóra Nógrádi-Halmi, Barbara Erdélyi-Furka, Zoltán Varga, Zsuzsanna Kahán, Tamás Csont   +6 more
doaj   +1 more source

Differential Extracellular Matrix Production by Mesenchymal Stromal Cells From Foetal Skin, Adult Skin and Burn Eschar

Wound Repair and Regeneration, Volume 34, Issue 5, September/October 2026.
ABSTRACT After full‐thickness injuries, foetal skin regenerates, while adult skin heals with scarring. Upon injury, mesenchymal stromal cells (MSCs) produce extracellular matrix (ECM) that shapes the wound microenvironment by providing structure, regulating the availability of soluble factors and directing cell behaviour. Therefore, the ECM secreted by
Madalena L. N. P. Gomes, Marcel Vlig, Amran Dinle, Paul A. J. Krijnen, Esther Middelkoop, Hans W. M. Niessen, Bouke K. H. L. Boekema   +6 more
wiley   +1 more source

Serum amyloid A–containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties

JCI Insight, 2020
The ability of HDL to inhibit inflammation in adipocytes and adipose tissue is reduced when HDL contains serum amyloid A (SAA) that is trapped by proteoglycans at the adipocyte surface.
Chang Yeop Han, Inkyung Kang, Mohamed Omer, Shari Wang, Tomasz Wietecha, Thomas N. Wight, Alan Chait   +6 more
doaj   +1 more source

Differential roles for small leucine-rich proteoglycans in bone formation

European Cells & Materials, 2003
This paper reviews our current state of knowledge of the roles the small leucine-rich proteoglycans (SLRPs) play in the formation of connective tissue and mineralised tissue matrices.
Waddington R. J., Roberts H. C., Sugars R. V., Schonherr E.   +3 more
doaj  

Biglycan promotes proliferation and metastasis of ovarian cancer

International Journal of Clinical and Experimental Pathology
Ovarian cancer (OC) is a significant threat to the health of women. Biglycan (BGN) plays a crucial role in the oncogenesis and progression of various human cancers. The aim of this study was to clarify the role of BGN in OC.Immunohistochemical analysis was performed to detect BGN levels in the OC tissues of 68 patients who underwent cytoreductive ...
Shan-Yu, Fang, Xue-Mei, Zhang, Xin-Ping, Chen   +2 more
openaire   +2 more sources

Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development1

Journal of Lipid Research, 2008
Angiotensin II (angII) is known to promote atherosclerosis; however, the mechanisms involved are not fully understood. To determine whether angII stimulates proteoglycan production and LDL retention, LDL receptor-deficient mice were infused with angII (1,
Fei Huang, Joel C. Thompson, Patricia G. Wilson, Hnin H. Aung, John C. Rutledge, Lisa R. Tannock   +5 more
doaj   +1 more source

Biologically enhanced deep learning for accurate and transparent Biglycan IHC-based breast cancer classification

Systems Science & Control Engineering
Biglycan-stained immunohistochemistry (IHC) slides for breast cancer diagnosis face three core challenges: staining variability, spatial heterogeneity of Biglycan overexpression, and the interpretability gap in existing deep learning models that limits ...
Martina Jaincy D. E., Pattabiraman Venkatasubbu   +1 more
doaj   +1 more source

Investigation of Inflammation and Autophagy due to Biglycan-mediated TLR2/4 Signaling in Oral Lichen Planus Tissues [PDF]

Forbes Tıp Dergisi
Objective: Oral lichen planus (OLP) is a chronic oral mucosal disease of unknown etiology. Cellular immune response, basement membrane, and extracellular matrix (ECM) molecules are also noteworthy in the pathogenesis.
Özlem Ceren GÜNİZİ, Hüseyin GÜNİZİ, Hamiyet ECİROĞLU, Fatma YILDIZ   +3 more
doaj   +1 more source

Polymorphism of BGN gene (g.77807325 G>C) and its association with fatty acid and carcass characteristics of Indonesian meat lamb

Journal of the Indonesian Tropical Animal Agriculture
Fatty acid content and carcass characteristics are two meat quality traits consumers choose to ob tain healthy and high-quality lamb. Genetic improvement of fatty acid content and carcass characteris tics in sheep is important to increase the public ...
M. F. Amin, C. Sumantri, I. I. Arief, A. Jayanegara, K. Listyarini, R. S. Harahap, A. Gunawan   +6 more
doaj   +1 more source

Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells

OncoImmunology, 2018
The extracellular matrix protein biglycan (BGN) has oncogenic or tumor suppressive potential depending on the cellular origin. HER-2/neu overexpression in murine fibroblasts and human model systems is inversely correlated with BGN expression.
Karthikeyan Subbarayan, Sandra Leisz, Claudia Wickenhauser, Daniel Bethmann, Chiara Massa, André Steven, Barbara Seliger   +6 more
doaj   +1 more source