Results 71 to 80 of about 13,898 (220)

Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis

Journal of Lipid Research, 2005
Retention of lipoproteins to proteoglycans in the subendothelial matrix (SEM) is an early event in atherosclerosis. We recently reported that collagen XVIII and its proteolytically released fragment endostatin (ES) are differentially depleted in blood ...
Xiaokun Zeng, Joshua Chen, Yury I. Miller, Kashi Javaherian, Karen S. Moulton   +4 more
doaj   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Biglycan Overexpression on Tooth Enamel Formation in Transgenic Mice [PDF]

The Anatomical Record, 2008
AbstractPreviously, it was shown that the volume of forming enamel of molar teeth in biglycan‐null mice was greater than that in genetically matched wild‐type mice. This phenotypic change appeared to result from an increase in amelogenin expression, implying that biglycan directly influences amelogenin synthesis.
Xin, Wen, Yanming, Zou, Wen, Luo, Michel, Goldberg, Rex, Moats, Peter S, Conti, Malcolm L, Snead, Michael L, Paine   +7 more
openaire   +2 more sources

Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion [PDF]

, 2014
Cancer progression is characterized by a complex reciprocity between neoplastic epithelium and adjacent stromal cells. In ductal carcinoma in situ (DCIS) of the breast, both reduced stromal decorin expression and myxoid stroma are correlated with ...
Bracke, Marc, Braems, Geert, Cocquyt, Veronique, De Vlieghere, Elly, De Wever, Olivier, Denys, Hannelore, Lambein, Kathleen, Libbrecht, Louis, LIMAME, RIDHA, Van Bockstal, Mieke, Van den Broecke, Rudy, Van Gele, Mireille   +11 more
core   +3 more sources

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists

Frontiers in Immunology, 2020
White adipose tissue but recently also brown adipose tissue have emerged as endocrine organs. Age-associated obesity is accompanied by prolonged and elevated lipopolysaccharide (LPS)-induced sickness symptoms and increased cytokine and adipokine levels ...
Verena Peek, Elena Neumann, Tomohiro Inoue, Sandy Koenig, Fabian Johannes Pflieger, Rüdiger Gerstberger, Joachim Roth, Joachim Roth, Kiyoshi Matsumura, Christoph Rummel, Christoph Rummel   +10 more
doaj   +1 more source

Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain

Frontiers in Oncology, 2023
Exit of quiescent disseminated cancer cells from dormancy is thought to be responsible for metastatic relapse and a better understanding of dormancy could pave the way for novel therapeutic approaches.
Ashley Sunderland, Jennifer Williams, Tereza Andreou, Nora Rippaus, Christopher Fife, Fiona James, Yolanda Dyah Kartika, Valerie Speirs, Ian Carr, Alastair Droop, Mihaela Lorger   +10 more
doaj   +1 more source

Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate. [PDF]

, 2019
Collagen remodeling occurs in many prostate pathologies; however, the underlying structural architecture in both normal and diseased prostatic tissues is largely unexplored.
Bushman, Wade A., Campagnola, Paul J., Campbell, Kirby R., Chaudhary, Rajeev, Iozzo, Renato V., Montano, Monica   +5 more
core   +1 more source

Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: a preliminary study on biglycan-deficient murine model of chronic disc degeneration [PDF]

, 2014
INTRODUCTION: Biglycan is an important proteoglycan of the extracellular matrix of intervertebral disc (IVD), and its decrease with aging has been correlated with IVD degeneration.
Alessandro Scotti, Clara Di Vito, Eugenio Parati, Giovanni Marfia, Giulio Alessandri, Ileana Zucca, Laura Riboni, Matteo Figini, Rolando Campanella, Stefania Elena Navone   +9 more
core   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source