Results 71 to 80 of about 8,243 (205)

Biglycan Regulation of Regional Tendon Development Via the Pericellular Matrix

, 2022
Tendons are a unique orthopaedic tissue that rely on a highly ordered tissue matrix for proper function. Tendon disease degrades this matrix order, causing deviations in resident cell behavior that result in decreased tissue function.
Leiphart, Ryan
core  

Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction [PDF]

Circulation, 2008
Background— After myocardial infarction (MI), extensive remodeling of extracellular matrix contributes to scar formation and preservation of hemodynamic function. On the other hand, adverse and excessive extracellular matrix remodeling leads to fibrosis and impaired function.
Westermann, D., Mersmann, J., Melchior, A., Freudenberger, T., Petrik, C., Schaefer, L., Lüllmann-Rauch, R., Lettau, O., Jacoby, C., Schrader, J., Brand-Herrman, S.M., Young, M.F., Schultheiss, H.P., Levkau, Bodo, Baba, Hideo Andreas, Unger, T., Zacharowski, K., Tschöpe, C., Fischer, J.W., Brand-Herrmann, S.-M.   +19 more
openaire   +3 more sources

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Biglycan deficiency causes spontaneous aortic dissection and rupture in mice

, 2007
BACKGROUND - For the majority of cases, the cause of spontaneous aortic dissection and rupture is unknown. An inherited risk is associated with Marfan syndrome, Ehlers-Danlos syndrome type IV, and loci mapped to diverse autosomal chromosomes. Analysis of
K. L. Nielsen, Heegaard, Anne-Marie, Danielsen, Carl Christian, BIANCO, Paolo, RIMINUCCI, MARA, CORSI, ALESSANDRO, Jorgensen, Henrik L., A. M. Heegaard, M. F. Young, C. C. Danielsen, Nielsen, Karina L., Young, Marian F., H. L. Jorgensen   +12 more
core   +1 more source

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

Detrimental Effect of Low‐Magnitude High‐Frequency Vibration in an Ex Vivo Model of Intervertebral Disc Degeneration Despite Estrogen Treatment

JOR SPINE, Volume 9, Issue 2, June 2026.
Low‐magnitude high‐frequency vibration (LMHFV), with or without 17β‐oestradiol (E2), exacerbated papain‐induced bovine intervertebral disc degeneration, reducing cell viability, impairing matrix production, and increasing inflammation. E2 showed no protective effect against papain‐induced degeneration or LMHFV.
Jan Ulrich Jansen, Felizitas Figel, Franziska Widmayer, Morten Vogt, Maria Ahrens, Hans‐Joachim Wilke, Anita Ignatius, Melanie Haffner‐Luntzer, Cornelia Neidlinger‐Wilke, Graciosa Quelhas Teixeira   +9 more
wiley   +1 more source

In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review [PDF]

European Cells & Materials, 2017
To promote and support tendon healing, one viable strategy is the use or administration of growth factors at the wound/rupture site. Platelet derived growth factor-BB (PDGF-BB), together with other growth factors, is secreted by platelets after injury ...
O Evrova, J Buschmann
doaj   +1 more source

Pathological classification of Fuchs endothelial corneal dystrophy into several types and their relationships with CTG18.1 expansion repeats

The Journal of Pathology, Volume 269, Issue 2, Page 182-196, June 2026.
Abstract Late‐onset Fuchs endothelial corneal dystrophy (FECD) is the most common primary disease of the corneal endothelium and the leading indication for corneal transplantation in Western countries. It is characterized by progressive accumulation, over two to three decades, of extracellular matrix (ECM) components in Descemet's membrane (DM ...
Hanielle Vaitinadapoulé, Daria Onitiu, Corantin Maurin, Gauthier Travers, Emmanuel Crouzet, Oliver Dorado‐Cortez, Sylvain Poinard, Zhiguo He, Fabien Forest, Edouard Ollier, Renaud Touraine, Philippe Gain, Jean‐Marc Perone, Gilles Thuret, the French Fuchs Study Group (FFSG), Diane Bernheim, Christophe Chiquet, Vincent Borderie, Tristan Bourcier, Jean‐Louis Bourges, Frédéric Chiambaretta, Béatrice Cochener, Louis Arnould, Florian Baudin, Catherine Creuzot, Vincent Daien, Alexandre Denoyer, Bernard Duchesne, Nicolas Duquesne, Pierre Fournie, Anne‐Sophie Gauthier, Philippe Gain, Gilles Thuret, Louis Hoffart, François Majo, Marc Muraine, Romain Mouchel, Jean Marc Perone, Jean Claude Quintyn, Alexandra Rabot, Alain Saad, Damien Gatinel, Pierre‐Yves Santiago, Jean‐Michel Bosc, David Touboul, Bertrand Vabres   +45 more
wiley   +1 more source

Molecular interactions of biglycan and decorin with elastic fiber components - Biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein

, 2002
© American Society for Biochemistry and Molecular BiologyThe interactions of the dermatan sulfate proteoglycans biglycan and decorin have been investigated with the elastic fiber components, tropoelastin, fibrillin-containing microfibrils, and ...
Reinboth, B., Hanssen, E., Cleary, E., Gibson, M.   +3 more
core   +1 more source