Results 81 to 90 of about 8,243 (205)

Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis [PDF]

Arthritis Research & Therapy, 2015
Soluble biglycan (sBGN) and soluble decorin (sDCN), are two closely related essential components of extracellular matrix which both have been shown to possess proinflammatory properties. We studied whether sBGN or sDCN were present in synovial fluid (SF) of osteoarthritis (OA) or rheumatoid arthritis (RA) patients and studied sBGN or sDCN potential ...
Barreto, Goncalo, Soininen, Antti, Ylinen, Pekka, Sandelin, Jerker, Konttinen, Yrjö T., Nordström, Dan C., Eklund, Kari K.   +6 more
openaire   +2 more sources

Osteoblast‐Derived Osteomodulin Suppresses Bone Loss in Osteoporosis by Inhibiting Osteoclastogenesis

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Osteoblast‐derived matricellular protein osteomodulin (OMD) critically regulates bone remodeling homeostasis via directly and competitively binding to RANKL, the master cytokine driving osteoclast formation. OMD shares overlapping binding sites on RANKL with osteoprotegerin and functional receptor RANK.
Meiling Jing, Xiaohan Zhu, Yueyi Yang, Xuchen Hu, Wenduo Tan, Xiaoyu Liu, Yujie Zhang, Xin Wang, Chenguang Niu, Zhengwei Huang   +9 more
wiley   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, Volume 13, Issue 28, 18 May 2026.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Associations of Adipocyte-derived Versican and Macrophage-derived Biglycan with Body Adipose Tissue and Hepatosteatosis in Obese Children

JCRPE
INTRODUCTION: In animal models of obesity, adipocyte-derived versican, and macrophage-derived biglycan play a crucial role in mediating adipose tissue inflammation.
Reyhan Deveci Sevim, Mustafa Gök, Özge Çevik, Ömer Erdoğan, Sebla Güneş, Tolga Ünüvar, Ahmet Anık   +6 more
doaj   +1 more source

The Proteoglycans Biglycan and Decorin Protect Cardiac Cells against Irradiation-Induced Cell Death by Inhibiting Apoptosis

Cells
Radiation-induced heart disease (RIHD), a common side effect of chest irradiation, is a primary cause of mortality among patients surviving thoracic cancer. Thus, the development of novel, clinically applicable cardioprotective agents which can alleviate
Renáta Gáspár, Petra Diószegi, Dóra Nógrádi-Halmi, Barbara Erdélyi-Furka, Zoltán Varga, Zsuzsanna Kahán, Tamás Csont   +6 more
doaj   +1 more source

Clinic Value of Blood Urea to Creatinine Ratio in Heart Failure Patients: A Systematic Review

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Elevated blood urea nitrogen‐to‐creatinine ratio (BCR) is associated with increased mortality, rehospitalization, and adverse clinical outcomes in heart failure patients; however, its prognostic accuracy is limited and its added value over established biomarkers remains uncertain.
Miguel Cabanillas‐Lazo, Roger A. Sernaqué‐Mechato, Alvaro Montes‐Baldarrago, Jeancarlo Velazco Muñoz, Valeria Loja Zapata, Ivan Alegre‐Cordero, Carlos Quispe‐Vicuña, Frank Mayta‐Tovalino   +7 more
wiley   +1 more source

Serum amyloid A–containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties

JCI Insight, 2020
The ability of HDL to inhibit inflammation in adipocytes and adipose tissue is reduced when HDL contains serum amyloid A (SAA) that is trapped by proteoglycans at the adipocyte surface.
Chang Yeop Han, Inkyung Kang, Mohamed Omer, Shari Wang, Tomasz Wietecha, Thomas N. Wight, Alan Chait   +6 more
doaj   +1 more source

Early Post‑Traumatic Osteoarthritis Features Greater Cartilage Extracellular Matrix Proteoglycan Loss Compared to the Pericellular Matrix

Journal of Orthopaedic Research, Volume 44, Issue 5, May 2026.
ABSTRACT Proteoglycan loss in articular cartilage is a hallmark of post‐traumatic osteoarthritis, and it can affect both chondrocyte biomechanics and tissue health. Previously, we found that 4 weeks after anterior cruciate ligament transection (ACLT) in rabbits, proteoglycan loss was less pronounced in the pericellular matrix (PCM) than in the ...
Rasmus K. Hiltunen, Nina Pesonen, Simo P. Ojanen, Mikko A. J. Finnilä, Sanna Palosaari, Walter Herzog, Simo Saarakkala, Rami K. Korhonen, Juuso T. J. Honkanen, Petri Tanska   +9 more
wiley   +1 more source

Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell‐specific liposomal siRNA delivery system

, 2022
Tumor blood vessels play important roles in tumor progression and metastasis. Targeting tumor endothelial cells (TECs) is one of the strategies for cancer therapy.
Alam, Mohammad Towfik, Morimoto, Masahiro, Nakamura, Takashi, Hiroto Hatakeyama, Kyoko Hida, Yasuhiro Hida, Ohga, Noritaka, Maishi, Nako, Sakurai, Yu, Yui Umeyama, Harashima, Hideyoshi, Umeyama, Yui, Kosuke Akiyama, Nako Maishi, Mohammad Towfik Alam, Endo, Rikito, Noritaka Ohga, Hida, Yasuhiro, Hiroshi Kikuchi, Yu Sakurai, Hatakeyama, Hiroto, Li, Cong, Masahiro Morimoto, Akiyama, Kosuke, Cong Li, Hideyoshi Harashima, Rikito Endo, Hirofumi Morimoto, Annan, Dorcas Akuba‐Muhyia, Morimoto, Hirofumi, Hida, Kyoko, Dorcas Akuba‐Muhyia Annan, Annan, Dorcas Akuba-Muhyia, Takashi Nakamura, Kikuchi, Hiroshi   +34 more
core   +1 more source

Biologically enhanced deep learning for accurate and transparent Biglycan IHC-based breast cancer classification

Systems Science & Control Engineering
Biglycan-stained immunohistochemistry (IHC) slides for breast cancer diagnosis face three core challenges: staining variability, spatial heterogeneity of Biglycan overexpression, and the interpretability gap in existing deep learning models that limits ...
Martina Jaincy D. E., Pattabiraman Venkatasubbu   +1 more
doaj   +1 more source