Results 101 to 110 of about 8,243 (205)
BiomedicinesPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type characterized by a marked desmoplastic tumor stroma that is formed under the influence of transforming growth factor (TGF)-β.
Hendrik Ungefroren +6 more
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Journal of Lipid Research, 2002 Atherosclerosis is the main cause of morbidity and mortality in diabetes, yet the underlying mechanisms remain unclear. Retention of atherogenic lipoproteins by vascular proteoglycans is thought to play a key role in the development of atherosclerotic ...
Lisa R. Tannock +3 more
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The Self-Association of Biglycan from Bovine Articular Cartilage
, 1994 Biglycan is a small dermatan sulfate proteoglycan present in the extracellular matrix of a variety of connective tissues. Sedimentation velocity and equilibrium studies were carried out to determine the monomer molecular weight of biglycan in denaturing ...
Choi, Haing U. +3 more
core
Pharmaceuticals, 2017 The indispensable roles of dermatan sulfate-proteoglycans (DS-PGs) have been demonstrated in various biological events including construction of the extracellular matrix and cell signaling through interactions with collagen and transforming growth factor-
Shuji Mizumoto +3 more
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Prognostic value of biglycan in gastric cancer
, 2020 Abstract Background: BGN (biglycan) is a family member of small leucine-rich repeat proteoglycans. High expression of BGN might enhance the invasion and metastasis in some types of tumors. Here, the prognostic significance of BGN was evaluated in gastric cancer.Material and Methods: Two independent Gene Expression Omnibus (GEO) gastric cancer ...
Sizhe Hu +3 more
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Expression of decorin, biglycan, and collagen type I in human renal fibrosing disease
, 2000 Expression of decorin, biglycan, and collagen type I in human renal fibrosing disease.BacκoundThe extracellular matrix proteoglycans decorin and biglycan may have a pathogenic role in renal fibrosing disease via regulation of the activity of growth ...
Stokes, Michael B. +7 more
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Characterization of biglycan and decorin self-association by analytical ultracentrifugation
, 1993 Biglycan and decorin are small, leucine-rich proteoglycans that bind to a variety of extracellular and membrane associated molecules, regulating their biological functions.
Liu, Jun
core
The structure and function of cartilage proteoglycans [PDF]
European Cells & Materials, 2006 Cartilage contains a variety of proteoglycans that are essential for its normal function. These include aggrecan, decorin, biglycan, fibromodulin and lumican. Each proteoglycan serves several functions that are determined by both its core protein and its
P J Roughley
doaj
Biglycan as a modulator of fibrous connective tissue
, 2002 Fibrous connective tissue contains fibroblasts distributed in a complex network of extracellular matrix molecules, such as proteoglycans. The small proteoglycans biglycan and decorin are composed of a protein core substituted with two and one ...
Tufvesson, Ellen
core
Role of biglycan on the immunogenicity of tumor cells
, 2022 Biglycan (BGN) underexpression was found in tumors of distinct origins, and evidence suggests an association with tumorigenicity. To establish a mechanistic link between the oncogene HER-2/neu and BGN, in vitro models of HER-2/neu-overexpressing murine fibroblasts and human mammary and melanoma carcinoma lesions were used.
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