Results 121 to 130 of about 13,898 (220)
Journal of Lipid Research, 2002 Atherosclerosis is the main cause of morbidity and mortality in diabetes, yet the underlying mechanisms remain unclear. Retention of atherogenic lipoproteins by vascular proteoglycans is thought to play a key role in the development of atherosclerotic ...
Lisa R. Tannock +3 more
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Degenerative suspensory ligament desmitis as a systemic disorder characterized by proteoglycan accumulation [PDF]
, 2006 Background Degenerative suspensory ligament desmitis (DSLD) is a debilitating disorder thought to be limited to suspensory ligaments of Peruvian Pasos, Peruvian Paso crosses, Arabians, American Saddlebreds, American Quarter Horses, Thoroughbreds, and ...
Jaroslava Halper +4 more
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BiomedicinesPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type characterized by a marked desmoplastic tumor stroma that is formed under the influence of transforming growth factor (TGF)-β.
Hendrik Ungefroren +6 more
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Pharmaceuticals, 2017 The indispensable roles of dermatan sulfate-proteoglycans (DS-PGs) have been demonstrated in various biological events including construction of the extracellular matrix and cell signaling through interactions with collagen and transforming growth factor-
Shuji Mizumoto +3 more
doaj +1 more source
Cellular and molecular pathology of age-related macular degeneration: Potential role for proteoglycans [PDF]
, 2016 Age-related macular degeneration (AMD) is a retinal disease evident after the age of 50 that damages the macula in the centre of retina. It leads to a loss of central vision with retained peripheral vision but eventual blindness occurs in many cases. The
Algwairi, O +4 more
core +2 more sources
Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans. [PDF]
, 2010 The small leucine-rich proteoglycans (SLRPs) are involved in many aspects of mammalian biology, both in health and disease. They are now being recognized as key signaling molecules with an expanding repertoire of molecular interactions affecting not only
Iozzo, Renato V., Schaefer, Liliana
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Prognostic value of biglycan in gastric cancer
, 2020 Abstract Background: BGN (biglycan) is a family member of small leucine-rich repeat proteoglycans. High expression of BGN might enhance the invasion and metastasis in some types of tumors. Here, the prognostic significance of BGN was evaluated in gastric cancer.Material and Methods: Two independent Gene Expression Omnibus (GEO) gastric cancer ...
Sizhe Hu +3 more
openaire +1 more source
The structure and function of cartilage proteoglycans [PDF]
European Cells & Materials, 2006 Cartilage contains a variety of proteoglycans that are essential for its normal function. These include aggrecan, decorin, biglycan, fibromodulin and lumican. Each proteoglycan serves several functions that are determined by both its core protein and its
P J Roughley
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High expression of biglycan is associated with poor prognosis in patients with esophageal squamous cell carcinoma [PDF]
, 2013 published_or_final_versio
Guan, X +5 more
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International Journal of General Medicine, 2021 Changming Shao,1,* Chunfa Cheng,2,* Qinshu Shao,3 Bing Chen1 1Department of Vascular Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, People’s Republic of China; 2Department of Vascular ...
Shao C, Cheng C, Shao Q, Chen B
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