Results 91 to 100 of about 13,898 (220)

In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review [PDF]

European Cells & Materials, 2017
To promote and support tendon healing, one viable strategy is the use or administration of growth factors at the wound/rupture site. Platelet derived growth factor-BB (PDGF-BB), together with other growth factors, is secreted by platelets after injury ...
O Evrova, J Buschmann
doaj   +1 more source

Decorin as a multivalent therapeutic agent against cancer. [PDF]

, 2016
Decorin is a prototypical small leucine-rich proteoglycan that epitomizes the multifunctional nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine kinases within the target-rich environment of the tumor stroma and tumor
Iozzo, Renato V., Neill, Thomas, Schaefer, Liliana   +2 more
core   +2 more sources

Early Post‑Traumatic Osteoarthritis Features Greater Cartilage Extracellular Matrix Proteoglycan Loss Compared to the Pericellular Matrix

Journal of Orthopaedic Research, Volume 44, Issue 5, May 2026.
ABSTRACT Proteoglycan loss in articular cartilage is a hallmark of post‐traumatic osteoarthritis, and it can affect both chondrocyte biomechanics and tissue health. Previously, we found that 4 weeks after anterior cruciate ligament transection (ACLT) in rabbits, proteoglycan loss was less pronounced in the pericellular matrix (PCM) than in the ...
Rasmus K. Hiltunen, Nina Pesonen, Simo P. Ojanen, Mikko A. J. Finnilä, Sanna Palosaari, Walter Herzog, Simo Saarakkala, Rami K. Korhonen, Juuso T. J. Honkanen, Petri Tanska   +9 more
wiley   +1 more source

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

Inbred Strain-Specific Effects of Exercise in Wild Type and Biglycan Deficient Mice [PDF]

, 2010
Biglycan (bgn)-deficient mice (KO) have defective osteoblasts which lead to changes in the amount and quality of bone. Altered tissue strength in C57BL6/129 (B6;129) KO mice, a property which is independent of tissue quantity, suggests that deficiencies ...
Darling, Eric M., Golcuk, Kurtulus, Kohn, David H., Morris, Michael D., Wallace, Joseph M.   +4 more
core   +1 more source

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G., Kamini Shivhare, Piyush Kumar Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rahul Shukla   +5 more
wiley   +1 more source

Fibromodulin and Biglycan Modulate Periodontium through TGFβ/BMP Signaling [PDF]

Journal of Dental Research, 2014
A full understanding of the key regulators controlling periodontal development and homeostasis is necessary for the design of improved periodontal regenerative therapies. Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules suggested to regulate collagen organization and cell signaling.
L, Wang, B L, Foster, V, Kram, F H, Nociti, P M, Zerfas, A B, Tran, M F, Young, M J, Somerman   +7 more
openaire   +2 more sources

Associations of Adipocyte-derived Versican and Macrophage-derived Biglycan with Body Adipose Tissue and Hepatosteatosis in Obese Children

JCRPE
INTRODUCTION: In animal models of obesity, adipocyte-derived versican, and macrophage-derived biglycan play a crucial role in mediating adipose tissue inflammation.
Reyhan Deveci Sevim, Mustafa Gök, Özge Çevik, Ömer Erdoğan, Sebla Güneş, Tolga Ünüvar, Ahmet Anık   +6 more
doaj   +1 more source

Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans [PDF]

, 2013
Calcific aortic valve disease is a progressive condition that shares some common pathogenic features with atherosclerosis. Transforming growth factor-ß1 is a recognized mediator of atherosclerosis and is expressed in aortic valve lesions.
Ballinger, M, Getachew, R, Grande-Allen, K, Little, P, Marasco, S, O', Osman, N   +6 more
core   +1 more source

Decorin and biglycan expression: its relation with endothelial heterogeneity.

Histology and histopathology, 2011
Decorin and biglycan proteoglycans play important roles in the organization of the extracellular matrix, and in the regulation of cell adhesion and migration. Given morphological and functional endothelial heterogeneity, information is needed regarding whether endothelial cells (ECs) from different vascular beds possess different profiles of ...
Calabrese G. C., Gazzaniga S., Oberkersch R., Wainstok R.   +3 more
openaire   +3 more sources