Results 41 to 50 of about 8,243 (205)

Role of glycosaminoglycans of biglycan in BMP-2 signaling [PDF]

Biochemical and Biophysical Research Communications, 2011
Recently we have reported that biglycan (BGN) promotes osteoblast differentiation and that this function is due in part to its ability to positively modulate bone morphogenetic protein (BMP) functions. In this study we investigated the role of glycosaminoglycans (GAGs) of BGN in this function using in vitro and in vivo models. C2C12 myogenic cells were
P A, Miguez, M, Terajima, H, Nagaoka, Y, Mochida, M, Yamauchi   +4 more
openaire   +2 more sources

Biglycan regulated colorectal cancer progress by modulating enteric neuron-derived IL-10 and abundance of Bacteroides thetaiotaomicron

iScience, 2023
Summary: Biglycan (BGN) is a proteoglycan with branch chains and highly expressed in enteric neurons in the tumor tissue of colorectal cancer (CRC), which is negatively associated with survival rates in patients with CRC.
Yuyu Xu, Fei Wang, Kai Mi, Xinyuan Wang, Danlei Wang, Qing Zhao, Jingjing Wang, Zhi Liu, Qingqing Zhang, Yang Liu, Xuemei Zhang, Xingyin Liu   +11 more
doaj   +1 more source

Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy

Molecules, 2022
We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Eef Allegaert, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
doaj   +1 more source

Adipose tissue biglycan as a potential anti-inflammatory target of sodium salicylate in mice fed a high fat diet

Journal of Inflammation, 2012
Background Inflammation in adipose tissue (AT) during obesity causes impaired AT function. Although multiple extracellular matrix (ECM) proteins are expressed in AT their potential role in adipose tissue inflammation is unclear.
Adapala Venkata J, Ward Meliza, Ajuwon Kolapo M   +2 more
doaj   +1 more source

Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer

OncoImmunology, 2022
Cancer-associated fibroblasts (CAFs) are essential for tumor microenvironment remodeling and correlate with tumor progression. However, interactions between CAFs and tumor cells and immune cells in triple-negative breast cancer (TNBC) are still poorly ...
Shaoquan Zheng, Yutian Zou, Yuhui Tang, Anli Yang, Jie-Ying Liang, Linyu Wu, Wenwen Tian, Weikai Xiao, Xinhua Xie, Lu Yang, Jindong Xie, Weidong Wei, Xiaoming Xie   +12 more
doaj   +1 more source

Extracellular Matrix Proteomics: The mdx-4cv Mouse Diaphragm as a Surrogate for Studying Myofibrosis in Dystrophinopathy

Biomolecules, 2023
The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation.
Paul Dowling, Stephen Gargan, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +4 more
doaj   +1 more source

Biglycan Modulates Osteoblast Differentiation and Matrix Mineralization [PDF]

Journal of Bone and Mineral Research, 2005
Abstract MC3T3-E1 cell-derived clones expressing higher (S) or lower (AS) levels of biglycan were generated and characterized. The processes of cell differentiation and matrix mineralization were accelerated in S but delayed in AS, indicating that BGN modulates osteoblastic cell differentiation. Introduction: Biglycan (BGN)
Duenpim, Parisuthiman, Yoshiyuki, Mochida, Wagner R, Duarte, Mitsuo, Yamauchi   +3 more
openaire   +2 more sources

Increased levels of biglycan in endometriomas and peritoneal fluid samples from ovarian endometriosis patients

, 2014
In our previous low-density-array gene-expression analysis we found an increased expression of biglycan gene in ovarian endometriosis patients. In the present study we evaluated biglycan expression at the protein level in tissue, serum and peritoneal ...
Mueller, Michael, Hevir-Kene, Neli, Rižner, Tea Lanišnik, Kocbek, Vida, Bersinger, Nick A.   +4 more
core   +1 more source

The Proteoglycan Biglycan Modulates Platelet Adhesion and Thrombus Formation in a GPVI-Dependent Manner

, 2021
Background: Vascular injury induces the exposure of subendothelial extracellular matrix (ECM) important to serve as substrate for platelets to adhere to the injured vessel wall to avoid massive blood loss.
Maria Grandoch, Jens W. Fischer, Margitta Elvers, Henrike Hoermann, Nadine Maurus, Friedrich Reusswig, Christina Kohlmorgen, Yi Sun, Irena Krueger   +8 more
core   +1 more source

Soluble biglycan as a biomarker of inflammatory renal diseases [PDF]

The International Journal of Biochemistry & Cell Biology, 2014
Chronic renal inflammation is often associated with a progressive accumulation of various extracellular matrix constituents, including several members of the small leucine-rich proteoglycan (SLRP) gene family. It is becoming increasingly evident that the matrix-unbound SLRPs strongly regulate the progression of inflammation and fibrosis.
Louise Tzung-Harn, Hsieh, Madalina-Viviana, Nastase, Jinyang, Zeng-Brouwers, Renato V, Iozzo, Liliana, Schaefer   +4 more
openaire   +2 more sources