Results 41 to 50 of about 13,898 (220)

The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. [PDF]

, 2013
Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments.
Maldonado, Maricela, Nam, Jin
core   +3 more sources

Prevention of renal apoB retention is protective against diabetic nephropathy: role of TGF-β inhibition[S]

Journal of Lipid Research, 2017
Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan.
Patricia G. Wilson, Joel C. Thompson, Meghan H. Yoder, Richard Charnigo, Lisa R. Tannock   +4 more
doaj   +1 more source

Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer

Thoracic Cancer, 2021
Objectives In lung cancer, surgery remains the most curative treatment and limited resection is beneficial for patients with low cardiopulmonary function and low malignancy tumors.
Hirofumi Morimoto, Yasuhiro Hida, Nako Maishi, Hiroshi Nishihara, Yutaka Hatanaka, Cong Li, Yoshihiro Matsuno, Toru Nakamura, Satoshi Hirano, Kyoko Hida   +9 more
doaj   +1 more source

Aberrant expression of the extracellular matrix component Biglycan regulated by Hedgehog signalling promotes colorectal cancer cell proliferation

Acta Biochimica et Biophysica Sinica, 2021
Hedgehog (Hh) signalling plays essential roles in regulating embryonic development and contributes to tumour initiation, growth and progression in multiple cancers.
Zeng Shaopeng, Zhou Feifei, Wang Yiqing, Zhai Zhenyu, Xu Linlin, Wang Hailong, Chen Xinping, Luo Shiwen, Cheng Minzhang   +8 more
doaj   +1 more source

Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells [PDF]

, 2007
Mesangial cells are thought to be important mediators of glomerular inflammation and fibrosis. Studies have established a direct role for nitric oxide (NO) in the regulation of gene expression in mesangial cells.
Banas B., Bannenberg G., Davies M., Gabbai F.B., Guzik T.J., Habib R., Huang S., Hubank M., Ohno M., Rangan G.K., Rosenberg H.G., Stengel B.   +11 more
core   +1 more source

ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan

Journal of Lipid Research, 2002
Retention of apolipoprotein (apo)B and apoE-containing lipoproteins by extracellular vascular proteoglycans is critical in atherogenesis. Moreover, high circulating apoC-III levels are associated with increased atherosclerosis risk.
Katherine Olin-Lewis, Ronald M. Krauss, Michael La Belle, Patricia J. Blanche, P.Hugh R. Barrett, Thomas N. Wight, Alan Chait   +6 more
doaj   +1 more source

Biglycan regulated colorectal cancer progress by modulating enteric neuron-derived IL-10 and abundance of Bacteroides thetaiotaomicron

iScience, 2023
Summary: Biglycan (BGN) is a proteoglycan with branch chains and highly expressed in enteric neurons in the tumor tissue of colorectal cancer (CRC), which is negatively associated with survival rates in patients with CRC.
Yuyu Xu, Fei Wang, Kai Mi, Xinyuan Wang, Danlei Wang, Qing Zhao, Jingjing Wang, Zhi Liu, Qingqing Zhang, Yang Liu, Xuemei Zhang, Xingyin Liu   +11 more
doaj   +1 more source

The matricellular functions of small leucine-rich proteoglycans (SLRPs) [PDF]

, 2009
The small leucine-rich proteoglycans (SLRPs) are biologically active components of the extracellular matrix (ECM), consisting of a protein core with leucine rich-repeat (LRR) motifs covalently linked to glycosaminoglycan (GAG) side chains.
Rosetta Merline, Roland M. Schaefer, Liliana Schaefer   +2 more
core   +1 more source

Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy

Molecules, 2022
We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Eef Allegaert, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
doaj   +1 more source

Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome [PDF]

, 2015
Proteomics techniques for analysing the redox status of individual proteins in complex mixtures tend to identify the same proteins due to their high abundance.
Bottazzi, Barbara, Chan, Philippe, Ghezzi, Pietro, Hammouz, Raneem, Mullen, Lisa, Seavill, Miles, Vaudry, David   +6 more
core   +1 more source