Results 81 to 90 of about 278,197 (298)
Food and Energy Security, 2020 Ruminant agriculture suffers from inefficient capture of forage protein and consequential release of N pollutants to land. This is due to proteolysis in the rumen catalyzed by both microbial but initially endogenous plant proteases.
Stephen Kamau +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Extracellular Proteolysis and Angiogenesis
, 2001 SummaryExtracellular proteolysis is an absolute requirement for new blood vessel formation, a process known as angiogenesis. This review will examine the role of the matrix metalloproteinase and plasminogen activator/plasmin systems during angiogenesis ...
Michael Pepper
core +1 more source
Aging and Proteolysis in Cultured Human Fibroblasts [PDF]
, 1980 Proteolysis of short-lived cellular proteins was investigated in early- and late-passage cells from normal donors and in cells from donors with the premature aging diseases of progeria and the Werner syndrome. Studies were conducted using intact cells or
Elliot, John Joseph
core +1 more source
Proteolisis status in the oral mucosa of rats after “mild” stress
Journal of Education, Health and SportBackground. Stress is one of the main causes of the development of most diseases. The role of proteolysis in the pathogenesis of post-stress reactions is not sufficiently elucidated. Aim.
K. Pavlenko
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Equations of replication and methylation, transcription, translation, and proteolysis.
, 2022 Equations of replication and methylation, transcription, translation, and proteolysis.
Chunrui Xu (5907374) +6 more
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Comparison of AcrB and CusA limited proteolysis.
, 2013 Panel A, proteolysis kinetics of CusA in C12M at a 1∶1000 ratio. Panel B, proteolysis kinetics of AcrB in C12M at a 1∶1000 ratio. M = Molecular weight markers.
Aurélie Goulielmakis (371785) +3 more
core +1 more source
Peptidomics for Studying Limited Proteolysis
, 2015 Limited proteolysis is a pivotal mechanism regulating protein functions. Identifying physiologically or pathophysiologically relevant cleavage sites helps to develop molecular tools that can be used for diagnostics or therapeutics.
Kazuki Sasaki (800935) +3 more
core +2 more sources