Results 81 to 90 of about 224,032 (260)
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Activation of a Flavoprotein by Proteolysis
Journal of Biological Chemistry, 1989 Chymotryptic digestion of brain pyridoxine-5-P oxidase brings about a 4-fold enhancement of the catalytic power (Vmax/KM) using pyridoxine-5-P as substrate in the assay mixtures. The chymotrypsin-treated enzyme is less susceptible to inhibition by pyridoxal-5-P than the native enzyme.
Y T, Kim, J E, Churchich
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
wiley +1 more source
Grasas y Aceites, 2002 In the present paper the addition of a commercial fat substitute based on whey proteins, alone or in combination with goat rennet and with a food grade protease, is analyzed.
M. C. Candioti +5 more
doaj +1 more source
Advanced Science, EarlyView.Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang +32 more
wiley +1 more source
Influence of postmortem aging and post-aging freezing on pork loin quality attributes
Meat and Muscle Biology, 2019 The objectives were to determine 1) the interaction between aging duration and post-aging freezing on pork loin quality attributes and 2) the relationship between pork loin star probe (SP) and Warner-Bratzler shear force (WBS).
Amanda C. Outhouse +10 more
doaj +2 more sources
A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation
Advanced Science, EarlyView.A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu +7 more
wiley +1 more source
Nitrogen matter changes during ripening of semihard cheese based on milk protein coaggregates
Mljekarstvo, 2007 Cheeses made on milk protein coaggregate basis are different thantraditionally made cheeses, in technological production process and sensory characteristics, especially texture and taste.
Snežana Jovanović +3 more
doaj
Physiological ReportsProlonged exposure to inescapable heat and humidity can lead to environment‐induced heat stress (EIHS). The extent to which EIHS damages the heart is largely unknown, though our previous work indicated EIHS caused ventricle‐dependent changes. The purpose
Melissa Roths +4 more
doaj +1 more source