Results 61 to 70 of about 272,745 (291)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Role of Stromal Proteolytic Systems in Cancer Progression (Review)

Общая реаниматология, 2019
Oncological diseases belong to life-threatening pathologies being the second most frequent cause of morbidity and mortality after cardiovascular diseases. Clarification of carcinogenesis mechanisms makes it possible to expand the stock of tools available
E. V. Kugaevskaya, O. S. Timoshenko, T. A. Gureeva, N. I. Solovieva   +3 more
doaj   +1 more source

The lowdown on breakdown: Open questions in plant proteolysis [PDF]

Proteolysis, including post-translational proteolytic processing as well as protein degradation and amino acid recycling, is an essential component of the growth and development of living organisms.
Jarvis, R, Theodoulou, F. L., Genschik, Pascal, Schnittger, A., Schaller, Andreas, Eckardt, N. A., Serino, G., Gibbs, Daniel, Noir, S., Chen, Qian, Xie, Q., Rodriguez, Pedro L, Chen, Poyu, Wittenberg, T. A., Noir, Sandra, Theodoulou, Frederica L, Zhang, H., Gibbs, D. J., Murcha, Monika, Serino, Giovanna, Üstün, Suayib, Murcha, M. W., Mursalimov, S., Chen, Q., Heese, Maren, Stintzi, Annick, Fang, Jun, Fang, J., Guercio, Angelica M, Guercio, Angelica, Chen, P., Schaller, A., Wei, N., Yu, F., Palayam, M., Peixoto, Bruno, Wei, Ning, Peixoto, B., van Wijk, K. J., Theodoulou, Frederica, Ghifari, Abi, Rodriguez, Pedro, Rodriguez, P. L., Michaeli, S., Gibbs, Daniel J, Genschik, P., van Wijk, Klaas, Mursalimov, Sergey, Xie, Qi, Guercio, A. M., Bassham, Diane, Shabek, Nitzan, Murcha, Monika W., Jarvis, R Paul, Ghifari, Abi S, van Wijk, Klaas J, Stintzi, A., Murcha, Monika W, Heese, M., Zhang, Hongtao, Gibbs, Daniel; id_orcid, Palayam, Malathy, Jarvis, R. P., Schnittger, Arp, Yu, Feifei, Üstün, S., Avin-Wittenberg, Tamar, Shabek, N., Bassham, Diane C, Eckardt, Nancy, Ghifari, A. S., Michaeli, Simon, Bassham, D. C., Eckardt, Nancy A   +73 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Influence of Aging Temperature and Duration on Spoilage Organism Growth, Proteolytic Activity, and Related Chemical Changes in Vacuum-Packaged Beef Longissimus

Meat and Muscle Biology, 2022
The objective was to evaluate the influence of vacuum-packaged aging temperature, duration, and their inter-action on spoilage organism growth, proteolytic activity, and resulting beef tenderness. Paired strip loins were collected from 60 USDA Low Choice
Dale R Woerner, J. C. Brooks, Jerrad F. Legako, M. Sebastian Hernandez, Tommy L. Wheeler   +4 more
doaj   +2 more sources

Avoiding Proteolysis During Protein Chromatography. [PDF]

, 2011
All cells contain proteases which effect catalytic hydrolysis of the peptide bond between amino acids in the protein backbone. Typically, proteinases are prevented from non-specific proteolysis by regulation and physical separation into different sub ...
Ryan, Barry
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Intramembrane Proteolysis of Astrotactins [PDF]

Journal of Biological Chemistry, 2017
Astrotactins are vertebrate-specific membrane proteins implicated in neuron-glia interactions during central nervous system development and in hair follicle polarity during skin development. By studying epitope-tagged derivatives of mouse astrotactin-2 (Astn2) produced in transfected cells, we determined that the amino and carboxyl termini reside in ...
Hao, Chang, Philip M, Smallwood, John, Williams, Jeremy, Nathans   +3 more
openaire   +2 more sources

Avoiding Proteolysis During Protein Purification [PDF]

, 2016
All cells contain proteases which hydrolyze the peptide bonds between amino acids in a protein backbone. Typically, proteases are prevented from nonspecific proteolysis by regulation and by their physical separation into different subcellular ...
Gary T. Henehan, Henehan, Gary T, Ryan, Barry J., Barry J. Ryan   +3 more
core   +1 more source