Results 61 to 70 of about 442,290 (346)
The role of TIMPs in regulation of extracellular matrix proteolysis.
Matrix Biology, 2015 Tissue inhibitors of metalloproteinases (TIMPs), which inhibit matrix metalloproteinases (MMPs) as well as the closely related, a disintegrin and metalloproteinases (ADAMs) and ADAMs with thrombospondin motifs (ADAMTSs), were traditionally thought to ...
V. Arpino, Michael Brock, S. Gill
semanticscholar +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Modelling primary proteolysis in cheddar cheese in commercial cool stores : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Bioprocess Engineering at Massey University [PDF]
, 2000 One issue identified as a possible problem during the manufacture of cheddar cheese is the possibility of producing a non-uniform product. It was proposed that a pallet of cheese experiencing different time-temperature histories, depending on the ...
Edmonds, Richard
core
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. [PDF]
, 2008 Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids; however, these responses come at the cost of potential autoimmunity owing to inappropriate recognition of self nucleic acids.
Barton, Gregory M +6 more
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Biomolecules, 2020 The aggregation of α-synuclein (α-Syn) is a characteristic of Parkinson’s disease (PD). α-Syn oligomerization/aggregation is accelerated by the serine peptidase, prolyl oligopeptidase (POP).
Gabriel S. Santos +4 more
doaj +1 more source
Nature, 1957 IT was shown by Linderstrom-Lang and co-workers1 that the tryptic hydrolysis of β-lactoglobulin involves the reversible denaturation of the protein as a preliminary stage. A consideration of known facts, together with new evidence obtained in connexion with an investigation of the mechanism of bating of skins in leather manufacture2, indicates that ...
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Gastroenterologìa, 2013 We have investigated the changes in the activity of plasma proteolysis indicators in patients with chronic obstructive pulmonary disease, associated with chronic pancreatitis, in the dynamics of treatment.
T.M. Khrystych +3 more
doaj +1 more source
Signal peptide peptidases and gamma-secretase: Cousins of the same protease family? [PDF]
, 2007 Signal peptide peptidase (SPIP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER).
Christian Haass +15 more
core +2 more sources