Results 61 to 70 of about 278,197 (298)
ubiquitin mediated proteolysis-png
, 2014 unigenes involved in ubiquitin mediated ...
Karen Fugate (480954)
core +1 more source
The Role of Stromal Proteolytic Systems in Cancer Progression (Review)
Общая реаниматология, 2019 Oncological diseases belong to life-threatening pathologies being the second most frequent cause of morbidity and mortality after cardiovascular diseases. Clarification of carcinogenesis mechanisms makes it possible to expand the stock of tools available
E. V. Kugaevskaya +3 more
doaj +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)
, 2022 Covering: upto 2022 Natural products have an embedded recognition of protein surfaces. They possess this property as they are produced by biosynthetic enzymes and are substrates for one or more enzymes in the biosynthetic pathway. The inherent advantages,
Liu, Miaomiao +2 more
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Meat and Muscle Biology, 2022 The objective was to evaluate the influence of vacuum-packaged aging temperature, duration, and their inter-action on spoilage organism growth, proteolytic activity, and resulting beef tenderness. Paired strip loins were collected from 60 USDA Low Choice
Dale R Woerner +4 more
doaj +2 more sources
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Dose-dependent proteolysis by rADAMTS13.
, 2015 A. Streptavidin coated microspheres bearing A2-77p-short were incubated with varying concentrations of rADAMTS13. Proteolysis was detected within 30min. even when protease concentration was 3.4% of normal plasma levels. B.
Chi Y. Lo (740890) +2 more
core +1 more source
Intramembrane Proteolysis of Astrotactins [PDF]
Journal of Biological Chemistry, 2017 Astrotactins are vertebrate-specific membrane proteins implicated in neuron-glia interactions during central nervous system development and in hair follicle polarity during skin development. By studying epitope-tagged derivatives of mouse astrotactin-2 (Astn2) produced in transfected cells, we determined that the amino and carboxyl termini reside in ...
Hao, Chang +3 more
openaire +2 more sources
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Molecular principles of assembly, activation, and inhibition in epithelial sodium channel
eLife, 2020 The molecular bases of heteromeric assembly and link between Na+ self-inhibition and protease-sensitivity in epithelial sodium channels (ENaCs) are not fully understood.
Sigrid Noreng +4 more
doaj +1 more source