Results 51 to 60 of about 31,301 (210)

Spatiotemporal Drug Delivery via a Neonatal Spinal Cord ECM Hydrogel for Biomimetic Microenvironment Remodeling After Spinal Cord Injury

Advanced Functional Materials, EarlyView.
A biomimetic hydrogel derived from neonatal spinal cord ECM (DNSCM) delivers LAMB2 protein and ISP peptide to remodel the inhibitory injury microenvironment. The system sustains drug release, upregulates pro‐regenerative LAMB2, downregulates inhibitory CSPG, and promotes axonal regeneration.
Shiyu Fu, Liangchao Du, Runlin Wen, Kai Zhang, Yu Zhou, Wanrong Ma, Zhiquan Yang, Dingyang Liu, Xing Li   +8 more
wiley   +1 more source

Microfabricated Anisotropic Myobundles for the Scalable Production of Cardiac Tissue Grafts

Advanced Functional Materials, EarlyView.
Controlling the anisotropy of cardiac tissue remains an outstanding challenge in the field of cardiac tissue engineering. Here, we introduce an approach to generate anisotropic cardiac myobundles using cell‐adhesive, synthetic, electrospun fibers and stem cell‐derived cardiac fibroblasts.
Maggie E. Jewett, Javiera Jilberto, Margaret E. Stanley, David O. Ntim, Siddhi M. Bhirud, Avianna T. Schroeder, Gonzola X. Anyosa Galvez, Jingyi Xia, Samuel J. DePalma, Emmanouil Agrafiotis, Susan S. Xi, Amanda S. Bluem, Courtney M. Lestock, Adam S. Helms, David A. Nordsletten, Brendon M. Baker   +15 more
wiley   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Proteolysis

Citation: 'proteolysis' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09776 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Feller-Kaiser, Urs, Nooden, Larry
openaire   +2 more sources

Food Allergens’ Susceptibility to Proteolysis

, 2020
Common properties of food allergens are prominent resistance to heat treatment and enzyme proteolysis. Stability of the proteins upon gastrointestinal proteolysis of food highly correlates with its allergenic potential.
Smiljanić, Katarina, Prodić, Ivana, Radosavljević, Jelena   +2 more
core  

Aging and Proteolysis in Cultured Human Fibroblasts [PDF]

, 1980
Proteolysis of short-lived cellular proteins was investigated in early- and late-passage cells from normal donors and in cells from donors with the premature aging diseases of progeria and the Werner syndrome. Studies were conducted using intact cells or
Elliot, John Joseph
core  

Comparison of AcrB and CusA limited proteolysis.

, 2013
Panel A, proteolysis kinetics of CusA in C12M at a 1∶1000 ratio. Panel B, proteolysis kinetics of AcrB in C12M at a 1∶1000 ratio. M = Molecular weight markers.
Aurélie Goulielmakis (371785), Eva Pebay-Peyroula (176938), Jacques Covès (371786), Aurélien Deniaud (176913)   +3 more
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

The structural characteristics of nonspecific lipid transfer proteins explain their resistance to gastroduodenal proteolysis.

, 2010
The structure and stability of the allergenic nonspecific lipid transfer protein (LTP) of peach were compared with the homologous LTP1 of barley and its liganded form LTP1b.
Abdullah, Syed U., Abdullah, S. U., Johnson, Paul, Smith, Lorna, Wijesinha-Bettoni, R, Mills, EN, Marsh, J., Shewry, Peter R., Wijesinha-Bettoni, R., Shewry, PR, Abdullah, SU, Alexeev, Y., Johnson, Phil, Marsh, J, Clare Mills, E. N., Johnson, P., Sancho, A. I., Wijesinha-Bettoni, Ramani, Alexeev, Yuri, Shewry, P. R., Alexeev, Y, Smith, LJ, Smith, Lorna J., Smith, L. J., Johnson, P, Mackie, Alan R., Sancho, AI, Mackie, AR, Sancho, Ana I., Mackie, A. R., Marsh, Justin, Mills, E. N. C.   +31 more
core   +1 more source

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source