Results 31 to 40 of about 442,290 (346)

Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep [PDF]

, 2006
The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms
Andréoletti, Banks, Baron, Baylis, Bieschke, Brown, Buschmann, Catherine Viguié, Chantal Imbs, Ecroyd, Elsen, Green, Hunter, Le Dur, Mohammed Moudjou, Morel, Moudjou, Nicole Picard-Hagen, Pierre-Louis Toutain, Rezaei, Safar, Toutain, Véronique Gayrard, Weller, Wong   +24 more
core   +3 more sources

PROteolysis TArgeting Chimeras (PROTACs) - Past, present and future.

Drug Discovery Today : Technologies, 2019
The majority of currently used therapeutics are small molecule-based and utilize occupancy-driven pharmacology as the mode of action (MOA), in which the protein function is modulated via temporary inhibition. New modalities that operate using alternative
M. Pettersson, C. Crews
semanticscholar   +1 more source

Proteolysis‐targeting chimeras in drug development: A safety perspective

British Journal of Pharmacology, 2020
Proteolysis‐targeting chimeras are a new drug modality that exploits the endogenous ubiquitin proteasome system to degrade a protein of interest for therapeutic benefit.
K. Moreau, M. Coen, Andrew X. Zhang, Fiona Pachl, M. P. Castaldi, Göran Dahl, H. Boyd, Clay Scott, P. Newham   +8 more
semanticscholar   +1 more source

Proteoform Analysis of Matrix Metalloproteinase-9/Gelatinase B and Discovery of Its Citrullination in Rheumatoid Arthritis Synovial Fluids

Frontiers in Immunology, 2021
ObjectivesTo explore posttranslational modifications (PTMs), including proteolytic activation, multimerization, complex formation and citrullination of gelatinases, in particular of gelatinase B/MMP-9, and to detect in gelatin-Sepharose affinity-purified
Bernard Grillet, Karen Yu, Estefania Ugarte-Berzal, Rik Janssens, Rafaela Vaz Sousa Pereira, Lise Boon, Erik Martens, Nele Berghmans, Isabelle Ronsse, Ilse Van Aelst, Pierre Fiten, René Conings, Jennifer Vandooren, Patrick Verschueren, Jo Van Damme, Paul Proost, Ghislain Opdenakker   +16 more
doaj   +1 more source

Methylated DNMT1 and E2F1 Are Targeted for Proteolysis by L3MBTL3 and CRL4DCAF5 Ubiquitin Ligase [PDF]

, 2018
Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves ...
Alejo, Salvador, Hoang, Nam, Leng, Feng, Lu, Fei, Sun, Hong, Yu, Jiekai, Zhang, Chunxiao, Zhang, Hui   +7 more
core   +3 more sources

Harnessing the Power of Proteolysis for Targeted Protein Inactivation.

Molecules and Cells, 2020
Two decades into the twenty-first century, a confluence of breakthrough technologies wielded at the molecular level is presenting biologists with unique opportunities to unravel the complexities of the cellular world.
R. Verma, D. Mohl, R. Deshaies
semanticscholar   +1 more source

Effect of Vipera berus berus and Vipera berus nikolskii venom on proteolytic balance in the tissue of the adrenal glands and testicles of rats

Biomedical and Biotechnology Research Journal, 2022
Background: Vipera berus berus and Vipera berus nikolskii are the most widely spread Old World vipers in Europe, who contribute to almost all cases of snakebites on this territory.
Mariia Palamarchuk, Timur Niyazmetov, Tetiana Halenova, Natalia Raksha, Oleksandr Maievskyi, Iryna Dzevulska, Kateryna Zaichko, Olexii Savchuk, Ludmila Ostapchenko   +8 more
doaj   +1 more source

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

Scientific Reports, 2018
Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes angiotensin-converting enzyme 2 (ACE2) as a host protein receptor and mediates ...
R. Kirchdoerfer, Nianshuang Wang, J. Pallesen, D. Wrapp, H. Turner, C. Cottrell, Kizzmekia S. Corbett, B. Graham, J. McLellan, A. Ward   +9 more
semanticscholar   +1 more source

Regulated degradation of the APC coactivator Cdc20

Cell Division, 2010
Background Cdc20 is a highly conserved activator of the anaphase-promoting complex (APC), promoting cell-cycle-regulated ubiquitination and proteolysis of a number of critical cell-cycle-regulatory targets including securin and mitotic cyclins. APC-Cdc20
Robbins Jonathan A, Cross Frederick R
doaj   +1 more source

The Bacillus subtilis signaling protein SpoIVB defines a new family of serine peptidases [PDF]

, 2002
The protein SpoIVB plays a key role in signaling in the sigma (K) checkpoint of Bacillus subtilis. This regulatory mechanism coordinates late gene expression during development in this organism and we have recently shown SpoIVB to be a serine peptidase ...
Brannigan, J A, Cutting, S M, Hoa, N T
core   +2 more sources