Results 11 to 20 of about 278,197 (298)
FoodsThe hydrolysis of proteins by proteases (proteolysis) plays a significant role in biology and food science. Despite the importance of proteolysis, a universal quantitative model of this phenomenon has not yet been created.
Mikhail M. Vorob’ev
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Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]
, 2011 Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory +2 more
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Self-Assembly of Proteolysis Targeting Chimeras Via Reversible Bioorthogonal Reactions [PDF]
, 2022 Targeted protein degradation (TPD) by PROteolysis TArgeting Chimeras (PROTACs) is of great interest for probe molecule and drug development. However, current bivalent PROTACs are rule-breaking molecules with sub-optimal cellular permeability, solubility,
Madeline, Balzarini +4 more
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Computational and Structural Biotechnology Journal, 2022 Aureolysin, a secreted metallopeptidase (MP) from the thermolysin family, functions as a major virulence factor in Staphylococcus aureus. No specific aureolysin inhibitors have yet been described, making this an important target for the development of ...
Soraia R. Mendes +7 more
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Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies
Frontiers in Endocrinology, 2022 The physiological roles of proteolysis are not limited to degrading unnecessary proteins. Proteolysis plays pivotal roles in various biological processes through cleaving peptide bonds to activate and inactivate proteins including enzymes, transcription ...
Daiji Kiyozumi +4 more
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Microbiome, 2021 Background Proteolysis regulation allows gut microbes to respond rapidly to dynamic intestinal environments by fast degradation of misfolded proteins and activation of regulatory proteins.
Zhixiang Yan +11 more
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, 2021 Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.
Niki Chondrogianni +2 more
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Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
eLife, 2020 APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55 ...
James Holder +2 more
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Nanomechanical in situ monitoring of proteolysis of peptide by Cathepsin B. [PDF]
PLoS ONE, 2009 Characterization and control of proteolysis of peptides by specific cellular protease is a priori requisite for effective drug discovery. Here, we report the nanomechanical, in situ monitoring of proteolysis of peptide chain attributed to protease ...
Taeyun Kwon +9 more
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European Respiratory Journal, 2003 Pulmonary emphysema is a major component of the morbidity and mortality of chronic obstructive pulmonary disease (COPD), a condition that has become the fourth leading cause of death in the USA, and is becoming epidemic worldwide. Emphysema is defined as enlargement of peripheral airspaces of the lung including respiratory bronchioles, alveolar ducts ...
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