Results 11 to 20 of about 224,032 (260)
, 2021 Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.
Niki Chondrogianni +2 more
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Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies
Frontiers in Endocrinology, 2022 The physiological roles of proteolysis are not limited to degrading unnecessary proteins. Proteolysis plays pivotal roles in various biological processes through cleaving peptide bonds to activate and inactivate proteins including enzymes, transcription ...
Daiji Kiyozumi +4 more
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Microbiome, 2021 Background Proteolysis regulation allows gut microbes to respond rapidly to dynamic intestinal environments by fast degradation of misfolded proteins and activation of regulatory proteins.
Zhixiang Yan +11 more
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European Respiratory Journal, 2003 Pulmonary emphysema is a major component of the morbidity and mortality of chronic obstructive pulmonary disease (COPD), a condition that has become the fourth leading cause of death in the USA, and is becoming epidemic worldwide. Emphysema is defined as enlargement of peripheral airspaces of the lung including respiratory bronchioles, alveolar ducts ...
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Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
eLife, 2020 APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55 ...
James Holder +2 more
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Nanomechanical in situ monitoring of proteolysis of peptide by Cathepsin B. [PDF]
PLoS ONE, 2009 Characterization and control of proteolysis of peptides by specific cellular protease is a priori requisite for effective drug discovery. Here, we report the nanomechanical, in situ monitoring of proteolysis of peptide chain attributed to protease ...
Taeyun Kwon +9 more
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Mljekarstvo, 2022 Kupres cheese is a traditional Bosnian full-fat hard cheese. This paper deals with the change of protein and fatty acid profiles, mineral content and antioxidant potential during the period of three months of its ripening.
Zlatan Sarić +8 more
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Epigenetics & Chromatin, 2023 Background Proteolysis of the histone H3 N-terminal tail (H3NT) is an evolutionarily conserved epigenomic feature of nearly all eukaryotes, generating a cleaved H3 product that is retained in ~ 5–10% of the genome.
Benjamin H. Weekley, Judd C. Rice
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Nature, 1957 IT was shown by Linderstrom-Lang and co-workers1 that the tryptic hydrolysis of β-lactoglobulin involves the reversible denaturation of the protein as a preliminary stage. A consideration of known facts, together with new evidence obtained in connexion with an investigation of the mechanism of bating of skins in leather manufacture2, indicates that ...
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Regulated degradation of the APC coactivator Cdc20
Cell Division, 2010 Background Cdc20 is a highly conserved activator of the anaphase-promoting complex (APC), promoting cell-cycle-regulated ubiquitination and proteolysis of a number of critical cell-cycle-regulatory targets including securin and mitotic cyclins. APC-Cdc20
Robbins Jonathan A, Cross Frederick R
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