Results 11 to 20 of about 272,745 (291)
Regulated Proteolysis in Bacteria [PDF]
Annual Review of Biochemistry, 2018 Regulated proteolysis is a vital process that affects all living things. Bacteria use energy-dependent AAA+ proteases to power degradation of misfolded and native regulatory proteins. Given that proteolysis is an irreversible event, specificity and selectivity in degrading substrates are key.
Samar A, Mahmoud, Peter, Chien
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FoodsThe hydrolysis of proteins by proteases (proteolysis) plays a significant role in biology and food science. Despite the importance of proteolysis, a universal quantitative model of this phenomenon has not yet been created.
Mikhail M. Vorob’ev
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Proteolysis in the rat lung: hypoxia and evidence for an inhibitor of proteolysis
American Journal of Physiology-Endocrinology and Metabolism, 1981 We labeled proteins with [14C]phenylalanine in rats breathing air and assessed the rate of proteolysis in the isolated ventilated lung by measuring the accumulation of [14C]phenylalanine in the medium perfusing the lung. Ventilation with 0% O2 decreased the rate of proteolysis and the ATP content in the lung 60%.
M J, Chiang +3 more
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Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]
, 2011 Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory +2 more
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Self-Assembly of Proteolysis Targeting Chimeras Via Reversible Bioorthogonal Reactions [PDF]
, 2022 Targeted protein degradation (TPD) by PROteolysis TArgeting Chimeras (PROTACs) is of great interest for probe molecule and drug development. However, current bivalent PROTACs are rule-breaking molecules with sub-optimal cellular permeability, solubility,
Madeline, Balzarini +4 more
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Computational and Structural Biotechnology Journal, 2022 Aureolysin, a secreted metallopeptidase (MP) from the thermolysin family, functions as a major virulence factor in Staphylococcus aureus. No specific aureolysin inhibitors have yet been described, making this an important target for the development of ...
Soraia R. Mendes +7 more
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Microbiome, 2021 Background Proteolysis regulation allows gut microbes to respond rapidly to dynamic intestinal environments by fast degradation of misfolded proteins and activation of regulatory proteins.
Zhixiang Yan +11 more
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, 2021 Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.
Niki Chondrogianni +2 more
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βTrCP-mediated proteolysis of NF-kB1 p105 requires phosphorylation of p105 serines 927 and 932 [PDF]
, 2003 This work was supported by the U.K. Medical Research Council, the Arthritis Research Campaign (project grant L0536 to V.L.), and the AINP consortium, EC—5th framework.NF-κB1 p105 functions both as a precursor of NF-κB1 p50 and as a cytoplasmic inhibitor ...
Ben-Neriah, Yinon +9 more
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Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
eLife, 2020 APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55 ...
James Holder +2 more
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