Results 21 to 30 of about 31,301 (210)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The lowdown on breakdown: Open questions in plant proteolysis [PDF]

Proteolysis, including post-translational proteolytic processing as well as protein degradation and amino acid recycling, is an essential component of the growth and development of living organisms.
Jarvis, R, Theodoulou, F. L., Genschik, Pascal, Schnittger, A., Schaller, Andreas, Eckardt, N. A., Serino, G., Gibbs, Daniel, Noir, S., Chen, Qian, Xie, Q., Rodriguez, Pedro L, Chen, Poyu, Wittenberg, T. A., Noir, Sandra, Theodoulou, Frederica L, Zhang, H., Gibbs, D. J., Murcha, Monika, Serino, Giovanna, Üstün, Suayib, Murcha, M. W., Mursalimov, S., Chen, Q., Heese, Maren, Stintzi, Annick, Fang, Jun, Fang, J., Guercio, Angelica M, Guercio, Angelica, Chen, P., Schaller, A., Wei, N., Yu, F., Palayam, M., Peixoto, Bruno, Wei, Ning, Peixoto, B., van Wijk, K. J., Theodoulou, Frederica, Ghifari, Abi, Rodriguez, Pedro, Rodriguez, P. L., Michaeli, S., Gibbs, Daniel J, Genschik, P., van Wijk, Klaas, Mursalimov, Sergey, Xie, Qi, Guercio, A. M., Bassham, Diane, Shabek, Nitzan, Murcha, Monika W., Jarvis, R Paul, Ghifari, Abi S, van Wijk, Klaas J, Stintzi, A., Murcha, Monika W, Heese, M., Zhang, Hongtao, Gibbs, Daniel; id_orcid, Palayam, Malathy, Jarvis, R. P., Schnittger, Arp, Yu, Feifei, Üstün, S., Avin-Wittenberg, Tamar, Shabek, N., Bassham, Diane C, Eckardt, Nancy, Ghifari, A. S., Michaeli, Simon, Bassham, D. C., Eckardt, Nancy A   +73 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Extracellular Proteolysis and Angiogenesis

, 2001
SummaryExtracellular proteolysis is an absolute requirement for new blood vessel formation, a process known as angiogenesis. This review will examine the role of the matrix metalloproteinase and plasminogen activator/plasmin systems during angiogenesis ...
Michael Pepper
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Product inhibition in native-state proteolysis.

, 2014
The proteolysis kinetics of intact proteins by nonspecific proteases provides valuable information on transient partial unfolding of proteins under native conditions.
Elizabeth C Andrews, Chiwook Park (652907), Joseph R Kasper, Chiwook Park, Joseph R. Kasper (652905), Elizabeth C. Andrews (652906)   +5 more
core   +1 more source

A Mathematical Model for Covalent Proteolysis Targeting Chimeras: Thermodynamics and Kinetics underlying Catalytic Efficiency

, 2021
Proteolysis targeting chimeras (PROTACs), heterobifunctional protein degraders, have emerged as an exciting and transformative technology in chemical biology and drug discovery to degrade disease-causing proteins through co-opting of the ubiquitin ...
Charu, Chaudhry
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Proteolysis, Texture and Microstructure of Goat Cheese [PDF]

, 2016
Changes in the structure of cheese are mostly due to changes in the protein matrix, mainly because of the degradation of α- and β- and k-casein. Therefore, the objective of this work was to study the effect of proteolysis on the microstructure and ...
Pece Azar, Nora Beatriz del Carmen, Maldonado, S., Burgos, Laura Silvina   +2 more
core