Results 21 to 30 of about 442,290 (346)
Nature Communications, 2020 Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the potential to prevent and treat various age-related diseases and extend healthspan.
Yonghan He +21 more
semanticscholar +1 more source
Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
eLife, 2020 APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55 ...
James Holder +2 more
doaj +1 more source
Proteolysis-Driven Oncogenesis [PDF]
Cell Cycle, 2007 An elevated expression of matrix metalloproteinases (MMPs) has been correlated with the growth and metastasis of preexisting tumors. The latest data, however, suggest that MMPs, by promoting genomic instability, are directly involved in the early stages of cell transformation from normalcy to malignancy and in incipient cancer.
Vladislav S, Golubkov, Alex Y, Strongin
openaire +2 more sources
Journal of Biological Chemistry, 1977 A rapid and convenient method for peptide mapping of proteins has been developed. The technique, which is especially suitable for analysis of proteins that have been isolated from gels containg sodium dodecyl sulfate, involves partial enzymatic ...
D. Cleveland +3 more
semanticscholar +1 more source
Trends in Genetics, 1999 Our present understanding of intracellular protein degradation developed from an attempt to understand the metabolic stability of proteins in cells. With the unravelling of its complex biochemical machinery has come a realization that protein degradation plays an important role in the most crucial events in the cell cycle, in signal transduction and in
M, Staszczak, E, Zdunek
openaire +4 more sources
Nanomechanical in situ monitoring of proteolysis of peptide by Cathepsin B. [PDF]
PLoS ONE, 2009 Characterization and control of proteolysis of peptides by specific cellular protease is a priori requisite for effective drug discovery. Here, we report the nanomechanical, in situ monitoring of proteolysis of peptide chain attributed to protease ...
Taeyun Kwon +9 more
doaj +1 more source
IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin [PDF]
, 2009 Background: Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage
Brundin, Patrick +4 more
core +3 more sources
PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics
Oncogene, 2020 Using PROteolysis TArgeting Chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has emerged as a potential therapeutic strategy for cancer. PROTACs are heterobifunctional molecules consisting of one ligand for binding to a protein
Sajid Khan +7 more
semanticscholar +1 more source
Epigenetics & Chromatin, 2023 Background Proteolysis of the histone H3 N-terminal tail (H3NT) is an evolutionarily conserved epigenomic feature of nearly all eukaryotes, generating a cleaved H3 product that is retained in ~ 5–10% of the genome.
Benjamin H. Weekley, Judd C. Rice
doaj +1 more source
eLife, 2021 The highly conserved protease Lon has important regulatory and protein quality control functions in cells from the three domains of life. Despite many years of research on Lon, only a few specific protein substrates are known in most organisms.
Deike J Omnus +3 more
doaj +1 more source