Results 71 to 80 of about 278,197 (298)

Phosphorylation Meets Proteolysis [PDF]

Structure, 2012
Phosphorylation is a reversible post-translational modification that regulates many proteins and enzymes, including proteases, as shown by two recent publications. Huang and colleagues and Velázquez-Delgado and Hardy (this issue of Structure) describe how phosphorylation activates the protease activity of the deubiquitinating enzyme DUBA and how it ...
Renatus, Martin, Farady, Christopher J.
openaire   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Food Allergens’ Susceptibility to Proteolysis

, 2020
Common properties of food allergens are prominent resistance to heat treatment and enzyme proteolysis. Stability of the proteins upon gastrointestinal proteolysis of food highly correlates with its allergenic potential.
Smiljanić, Katarina, Prodić, Ivana, Radosavljević, Jelena   +2 more
core   +4 more sources

The Contribution of Plant Dioxygenases to Hypoxia Signaling

Frontiers in Plant Science, 2020
Dioxygenases catalyze the incorporation of one or two oxygen atoms into target organic substrates. Besides their metabolic role, these enzymes are involved in plant signaling pathways as this reaction is in several instances required for hormone ...
Sergio Iacopino, Sergio Iacopino, Sergio Iacopino, Francesco Licausi, Francesco Licausi, Francesco Licausi   +5 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

The lowdown on breakdown: Open questions in plant proteolysis [PDF]

Proteolysis, including post-translational proteolytic processing as well as protein degradation and amino acid recycling, is an essential component of the growth and development of living organisms.
Theodoulou, F. L., Genschik, Pascal, Schnittger, A., Schaller, Andreas, Eckardt, N. A., Serino, G., Noir, S., Chen, Qian, Xie, Q., Rodriguez, Pedro L, Chen, Poyu, Wittenberg, T. A., Noir, Sandra, Theodoulou, Frederica L, Zhang, H., Gibbs, D. J., Serino, Giovanna, Üstün, Suayib, Murcha, M. W., Mursalimov, S., Chen, Q., Heese, Maren, Stintzi, Annick, Fang, Jun, Fang, J., Guercio, Angelica M, Chen, P., Schaller, A., Wei, N., Yu, F., Palayam, M., Peixoto, Bruno, Wei, Ning, Peixoto, B., van Wijk, K. J., Rodriguez, P. L., Michaeli, S., Gibbs, Daniel J, Genschik, P., Mursalimov, Sergey, Xie, Qi, Guercio, A. M., Shabek, Nitzan, Murcha, Monika W., Jarvis, R Paul, Ghifari, Abi S, van Wijk, Klaas J, Stintzi, A., Murcha, Monika W, Heese, M., Zhang, Hongtao, Gibbs, Daniel; id_orcid, Palayam, Malathy, Jarvis, R. P., Schnittger, Arp, Yu, Feifei, Üstün, S., Avin-Wittenberg, Tamar, Shabek, N., Bassham, Diane C, Ghifari, A. S., Michaeli, Simon, Bassham, D. C., Eckardt, Nancy A, Wei, N, Heese, M. (Maren), Murcha, M. (Monika W), Michaeli, S. (Simon), Mursalimov, S, Theodoulou, Frederica, L, Theodoulou, F. (Frederica L), van Wijk, K. (Klaas J), Rodriguez Egea, Pedro Luis, Murcha, Monika, W, Rodriguez, Pedro, L, Schnittger, A, Jarvis, R, Paul, Zhang, H. (Hongtao), Palayam, M. (Malathy), Guercio, A. (Angelica M), Chen, P. (Poyu), Stintzi, A, Xie, Q, Murcha, M.W., Michaeli, S, Peixoto, B. (Bruno), Jarvis, R. (R Paul), Guercio, A.M, Wei, N. (Ning), Bassham, D. (Diane C), Eckardt, N.A, Ghifari, A.S, Bassham, D.C, Stintzi, A. (Annick), Genschik, P. (Pascal), Genschik, P, Zhang, H, Serino, G. (Giovanna), Yu, F, Serino, G, Gibbs, Daniel, J, Guercio, Angelica, M, Bassham, Diane, C, Schaller, A. (Andreas), Fang, J. (Jun), Gibbs, D.J, Mursalimov, S. (Sergey), Ghifari, Abi, S, Avin-Wittenberg, T. (Tamar), Schaller, A, Noir, S. (Sandra), Fang, J, van Wijk, Klaas, J, Rodriguez, P. (Pedro L), Shabek, N, van Wijk, K.J, Eckardt, N. (Nancy A), Chen, Q. (Qian), Xie, Q. (Qi), Avin-Wittenberg, T., Theodoulou, F.L, Peixoto, B, Chen, P, Gibbs, D. (Daniel J), Heese, M, Noir, S, Üstün, S, Üstün, S. (Suayib), Eckardt, Nancy, A, Ghifari, A. (Abi S), Jarvis, R.P., Yu, F. (Feifei), Schnittger, A. (Arp), Shabek, N. (Nitzan)   +133 more
core   +1 more source

Proteolysis in Danish blue cheese during ripening [PDF]

, 2019
Proteolysis in Danish blue cheese was studied during 9 weeks' ripening. Levels of pH 4.6-soluble N as a percentage of total N increased from 7.2% to 25%, indicating extensive proteolysis.
Mane, Anuya, Lillevang, S. K., Ciocia, Felicia, Beck, T. K., McSweeney, Paul L. H.   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Regulated Proteolysis in Bacteria [PDF]

Annual Review of Biochemistry, 2018
Regulated proteolysis is a vital process that affects all living things. Bacteria use energy-dependent AAA+ proteases to power degradation of misfolded and native regulatory proteins. Given that proteolysis is an irreversible event, specificity and selectivity in degrading substrates are key.
Samar A, Mahmoud, Peter, Chien
openaire   +2 more sources

Targeted enzymatic therapy for coeliac disease

EMBO Molecular Medicine
Coeliac disease (CD) is an autoimmune enteropathy triggered by proline-rich gluten immunogenic peptides (GIPs), for which no curative therapy exists. We developed celiacase (Clc), a recombinant prolyl endopeptidase engineered from pitcher plant neprosin ...
Marina Girbal-González, Arturo Rodríguez-Banqueri, Hadeel Swaid, Soraia R Mendes, Laura Garzón-Flores, Juan Sebastián Ramírez-Larrota, Carolina Cueva, M Victoria Moreno-Arribas, Christof Regl, Christian G Huber, Katharina A Scherf, María José Rodríguez-Lagunas, Àngels Franch-Masferrer, Ulrich Eckhard, Francisco J Pérez-Cano, F Xavier Gomis-Rüth   +15 more
doaj   +1 more source