Results 241 to 250 of about 416,903 (305)

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood

Annals of Neurology, EarlyView.
We used targeted immunopurification‐mass spectrometry (IP‐MS) to characterize human neurofilament light chain (NfL) proteoforms across various compartments to assess their alterations in amyotrophic lateral sclerosis (ALS). NfL is truncated in cerebrospinal fluid (CSF) and blood in patients with sporadic ALS (sALS) and these proteoforms differ between ...
John B. Coulton, Yingxin He, Melissa M. Budelier, Nicolas Barthélemy, Margaret D. Ireland, Miwei Hu, Danielle Graham, Toby Ferguson, James D. Berry, Randall J. Bateman, Timothy M. Miller, Cindy V. Ly   +11 more
wiley   +1 more source

[Proteolytic activity of bile].

Medycyna doswiadczalna i mikrobiologia, 2004
openaire   +1 more source

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Proteolytic activity of largomycin

Biochimica et Biophysica Acta (BBA) - General Subjects, 1985
Largomycin, an antibiotic and antitumor protein, purified from the culture broth of Streptomyces pluricolorescens, displayed specific proteolytic activity. Pure largomycin did not degrade a number of substrates commonly used for detection of aminopeptidase, endopeptidase and carboxypeptidase activity. Pure largomycin degraded angiotensin II, bradykinin,
A, Zaheer, S, Zaheer, R, Montgomery
openaire   +2 more sources

Proteolytic activities in yeast

Biochimica et Biophysica Acta (BBA) - Enzymology, 1975
Studies on the mechanism and time course of the activation of proteinases A (EC 3.4.23.8), B (EC 3.4.22.9) and C (EC 3.4.12.--) in crude yeast extracts at pH 5.1 and 25 degrees C showed that the increase in proteinase B activity is paralleled with the disappearance of proteinase B inhibitor.
T, Saheki, H, Holzer
openaire   +2 more sources

Proteolytic Activity Assays in Haloarchaea

2022
Extreme halophilic archaea (haloarchaea) have adapted their physiology and biomolecules to thrive in saline environments (>2 M NaCl). Many haloarchaea produce extracellular hydrolases (including proteases) with potential biotechnological applications, which require unusual high salt concentrations to attain their function and maintain their stability ...
Roberto Alejandro Paggi, María Inés Giménez, Rosana Esther De Castro   +2 more
openaire   +2 more sources

Proteolytic and Non-Proteolytic Activation of Prorenin

1998
Largely because of its importance in the pathophysiology of cardiovascular diseases, renin has been intensely studied as a target for drug inhibition. Like most other aspartyl proteases, mammalian renins are synthesized in vivo as inactive precursors called prorenins. Although the crystal structure of prorenin has not yet been reported, it seems likely
T L, Reudelhuber, V, Brechler, I, Jutras, C, Mercure, D, Methot   +4 more
openaire   +2 more sources