Results 111 to 120 of about 115,149 (302)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Dynamic changes in ANGUSTIFOLIA3 complex composition reveal a growth regulatory mechanism in the maize leaf [PDF]

, 2015
Most molecular processes during plant development occur with a particular spatio-temporal specificity. Thus far, it has remained technically challenging to capture dynamic protein-protein interactions within a growing organ, where the interplay between ...
Aesaert, Stijn, Candaele, Jasper, De Block, Jolien, De Jaeger, Geert, Demuynck, Kirin, Eeckhout, Dominique, Gevaert, Kris, Goormachtig, Sofie, Inzé, Dirk, Muszynski, Michael, Nelissen, Hilde, Persiau, Geert, Van Bel, Michiel, Van Leene, Jelle, Van Lijsebettens, Maria, Vandepoele, Klaas, Vervoort, Marieke, Walton, Alan   +17 more
core   +2 more sources

PSMB4: a potential biomarker and therapeutic target for depression, perspective from integration analysis of depression GWAS data and human plasma proteome

Translational Psychiatry
Depression is a common and severe mental disorder that affects more than 300 million people worldwide. While it is known to have a moderate genetic component, identifying specific genes that contribute to the disorder has been challenging.
Jiewei Liu
doaj   +1 more source

Global Functional Atlas of \u3cem\u3eEscherichia coli\u3c/em\u3e Encompassing Previously Uncharacterized Proteins [PDF]

, 2009
One-third of the 4,225 protein-coding genes of Escherichia coli K-12 remain functionally unannotated (orphans). Many map to distant clades such as Archaea, suggesting involvement in basic prokaryotic traits, whereas others appear restricted to E.
Ali, Mehrab, Babu, Mohan, Butland, Gareth, Chandran, Shamanta, Christopolous, Constantine, Emili, Andrew, Eroukova, Veronika, Golshani, Ashkan, Greenblatt, Jack F., Guao, Xinghua, Hu, Pingzhao, Janga, Sarah Chandra, Moreno-Hagelsieb, Gabriel, Musso, Gabriela, Nazarians-Armavil, Anaies, Nazemof, Nazila, Paccanaro, Alberto, Phanse, Sadhna, Pogoutse, Oxana, Wong, Peter, Yang, Wenhong   +20 more
core   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Revealing the genetic complexity of hypothyroidism: integrating complementary association methods

Frontiers in Genetics
Hypothyroidism is a common endocrine disorder whose prevalence increases with age. The disease manifests itself when the thyroid gland fails to produce sufficient thyroid hormones.
Roei Zucker, Michael Kovalerchik, Amos Stern, Hadasa Kaufman, Michal Linial   +4 more
doaj   +1 more source

Conservation of core complex subunits shaped the structure and function of photosystem I in the secondary endosymbiont alga Nannochloropsis gaditana [PDF]

, 2017
Photosystem I (PSI) is a pigment protein complex catalyzing the light-driven electron transport from plastocyanin to ferredoxin in oxygenic photosynthetic organisms.
Alboresi, Alessandro Alboresi, Allen, Andrea Meneghesso, Archibald, Basso, Ben-Shem, Bernal-Bayard, Boekema, Boekema, Bondioli, Busch, Busch, Busch, Castelletti, Caterina Gerotto, Cavalier-Smith, Clotilde Le Quiniou, Corteggiani Carpinelli, Cox, Croce, Croce, Croce, Diana Simionato, Drop, Drop, Egbert J. Boekema, Engelmann, Färber, Gardian, Geer, Gobets, Gobets, Grouneva, Haldrup, Ikeda, Jansson, Jennings, Jensen, Jensen, Jordan, Khrouchtchova, Kouril, Kouril, Le Corguillé, Le Quiniou, Le Quiniou, Li, Litvín, Liu, Lunde, Martin Scholz, Mazor, Michael Hippler, Morosinotto, Mozzo, Nelson, Oostergetel, Palacios, Passarini, Passarini, Qin, Raven, Riisberg, Roberta Croce, Rodolfi, Sathish K. N. Yadav, Scheres, Scheres, Schmid, Shevchenko, Simionato, Snellenburg, Starkenburg, Sukenik, Sukenik, Terashima, Thangaraj, Tomas Morosinotto, van Stokkum, Vanselow, Veith, Vieler, Watanabe, Watanabe, Wientjes, Wientjes, Wientjes   +87 more
core   +3 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Evaluation of circulating plasma proteins in prostate cancer using mendelian randomization

Discover Oncology
Background The proteome is an important resource for exploring potential diagnostic and therapeutic targets for cancer. This study aimed to investigate the causal associations between plasma proteins and prostate cancer (PCa), and to explore the ...
Long Cheng, Zeming Qiu, Xuewu Wu, Zhilong Dong   +3 more
doaj   +1 more source

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source