Results 121 to 130 of about 260,383 (299)

Multi-omic characterization of air pollution effects: Applications of AirSigOmniTWP Hub

Ecotoxicology and Environmental Safety
Air pollution, particularly fine particulate matter and gaseous pollutants including NO2 and NOx, presents significant public health challenges. While the harmful effects of these pollutants are well-documented, the molecular mechanisms underlying their ...
Wei Liu, Tong Liu, Xinxin Si, Jiaxing Liang, Xia Yan, Juexin Zhang, Bing Pang, Wenmin Luo, Junhong Liu, Huazhe Yang, Peng Shi   +10 more
doaj   +1 more source

Bone‐Derived dECM Hydrogels Support Tunable Microenvironments for In Vitro Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Minne Dekker, Luke Hipwood, Akhilandeshwari Ravichandran, Dietmar W. Hutmacher, Christoph Meinert, Jacqui McGovern   +5 more
wiley   +1 more source

An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis

Communications Biology
Psoriatic arthritis (PsA) is a complex, chronic immune-mediated inflammatory arthropathy that currently lacks definitive biomarkers and treatment targets. Identifying biomarkers and treatment targets is urgently needed for effectively managing PsA. Here,
Yi-Xin Cai, Dai-Shan Zheng, Xiao-Li Chen, Zhan-Pei Bai, Jinyi Zhang, Wenhai Deng, Xiu-Feng Huang   +6 more
doaj   +1 more source

Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration

Advanced Healthcare Materials, EarlyView.
Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu, Philip C N Chiu, Ernest H Y Ng, Sentao Hu, Zi Ye, Liaobing Xin, Lie Ma, Songying Zhang, William S B Yeung, Rachel W S Chan   +9 more
wiley   +1 more source

Admixture-mapping analysis reveals genetic determinants of the human plasma proteome

HGG Advances
Summary: Protein profiling and genetic findings can be integrated to define the genetic architecture of the circulating proteome in chronic diseases. Most self-identified African American (AA) individuals have both African and European genetic ancestry ...
Daniel E. Cruz, Shuliang Deng, Usman A. Tahir, Zsu-Zsu Chen, Mark D. Benson, Bjoernar Tuftin, Jiawen Chen, Laurie Farrell, Dongxiao Shen, Mariah Meyer, Ethan Lange, Yan Gao, Michael E. Hall, Russell P. Tracy, Stephen S. Rich, Kent Taylor, Ani Manichaikul, Jerome I. Rotter, Tamar Sofer, James G. Wilson, Robert E. Gerszten, Laura M. Raffield   +21 more
doaj   +1 more source

Human Brain Proteome-Wide Association Study Implicates Potential Therapeutic Targets for Obesity

, 2023
Qi‐Gang Zhao, Xin-Ling Ma, Qian Xu, Zi-Tong Song, Fan Bu, Kuan Li, Lei Zhang, Yu‐Fang Pei   +7 more
openalex   +1 more source

Using High‐Throughput Screening to Identify Crosslinking Peptides That Control Cell‐Mediated Matrix Degradation

Advanced Healthcare Materials, EarlyView.
Protease‐degradable hydrogels mimic dynamic cell‐matrix interactions, but controlling hydrogel degradation is a challenge. We screen libraries of peptides to identify sequences that are primarily degraded by membrane‐localized proteases. Crosslinking hydrogels with these peptides enables cell to spread and migrate while reducing matrix degradation ...
Yingjie Wu, Samuel J. Rozans, Abolfazl Salehi Moghaddam, E. Thomas Pashuck   +3 more
wiley   +1 more source

Genetic insights support PARP1 as a mediator in the protective association of ATP-citrate lyase inhibitors with melanoma

Communications Biology
ATP-citrate lyase (ACLY) inhibitors emerge as a promising anti-cancer strategy, yet their causal effects across various cancer types remain unclear.
Jiawen Lu, Gloria Hoi-Yee Li, Jingyi Hu, Zhenqian Wang   +3 more
doaj   +1 more source

Synthetic Cell‐Based Tissues for Bottom‐Up Assembly of Artificial Lymphatic Organs

Advanced Healthcare Materials, EarlyView.
Synthetic cells have emerged as a novel biomimetic approach for fundamental research and therapeutic interventions. T cell activating synthetic cells are able to form 3D tissue‐like structures by self‐assembly into lymphatic bottom‐up tissues (lymphBUT) with tunable biochemical and biomechanical functionalities as well as metabolic activity are ...
Anna Burgstaller, Tamara Nink, Niklas Walter, Erick Angel Lopez Lopez, Hsin‐Fang Chang, Oskar Staufer   +5 more
wiley   +1 more source

Microneedles From Shape‐Preserving Crosslinked Poly(Vinyl Alcohol) Hydrogels: Minimising Interference in Transdermal Proteomics

Advanced Materials Technologies, EarlyView.
Hydrogel‐forming microneedle patches are developed using shape‐preserving PVA‐PVP hydrogels, with and without chitosan, for minimally invasive transdermal protein biomarker sampling. The optimised patches enable efficient interstitial fluid uptake and proteomic analysis, while minimising interference.
Achmad Himawan, Robert Graham, Fabiana Volpe‐Zanutto, Huanhuan Li, Anjali K. Pandya, Andi Nur Aisyah, Rina Agustina, Juan L. Paris, Juan Dominguez‐Robles, Lalitkumar K. Vora, Andi D. Permana, Christopher J. Scott, Ryan F. Donnelly   +12 more
wiley   +1 more source