Results 111 to 120 of about 41,903,721 (265)
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui +25 morewiley +1 more sourceThe Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella +25 morewiley +1 more sourceIntegrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics
European Journal of Medical ResearchBackground This study aimed to explore associations and causality between excessive daytime sleepiness (EDS), narcolepsy, and hypertension. Methods Publicly available data from the National Health and Nutrition Examination Survey (NHANES), genome-wide ...Shenghui Feng, Xiangfei Liu, Yibo Sun, Yaoyao Cai, Shen Chen, Yan Liang +5 moredoaj +1 more sourceDysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis
Advanced Science, EarlyView.Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu +14 morewiley +1 more sourceOTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function
Advanced Science, EarlyView.In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT
Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang +15 morewiley +1 more sourceA genome-wide association search for type 2 diabetes genes in African Americans. [PDF]
, 2012 African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity.Kumari, Meena, Seedorf, Udo, Sladek, Rob, Wu, Guanming, Rocheleau, Ghislain, McCarroll, Steve A, Bostrom, Meredith A, Pedersen, Oluf, Sanna, Serena, Marmot, Michael, McCarthy, Mark I, Amin, Najaf, van Dijk, Ko Willems, Divers, Jasmin, Hicks, Andrew A, Yarnell, John W G, Pearson, Daniel, Langefeld, Carl D, Dedoussis, George V, Elliott, Paul, Kao, Wen H L, Owen, Katharine R, Kaprio, Jaakko, Cavalcanti-Proença, Christine, Cooper, Matthew N, van Haeften, Timon W, Navarro, Pau, Strassburger, Klaus, Hammond, Naomi, Qi, Lu, McCulloch, Laura J, Uitterlinden, André G, Groves, Christopher J, Tönjes, Anke, Barroso, Inês, Palmer, Nicholette D, Kyvik, Kirsten Ohm, Waeber, Gérard, Boehm, Bernhard O, Loos, Ruth J F, Sijbrands, Eric, Bochud, Murielle, Boerwinkle, Eric, Bowden, Donald W, Lind, Lars, Le Bacquer, Olivier, Kong, Augustine, Mooser, Vincent, Timpson, Nicholas J, Pakyz, Ruth, Meisinger, Christa, Hartikainen, Anna-Liisa, Jarvelin, Marjo-Riitta, Wichmann, H-Erich, Ardlie, Kristin, Klopp, Norman, Goel, Anuj, Wright, Alan F, Franzosi, Maria Grazia, de Geus, Eco J C, Hallmans, Göran, Pramstaller, Peter Paul, Raychaudhuri, Soumya, Syvänen, Ann-Christine, Cauchi, Stephane, Salomaa, Veikko, Han, Xijing, Zethelius, Björn, Collins, Francis S, Blagieva, Roza, Hillman, David R, Ingelsson, Erik, Singleton, Andrew, Williams, Gordon H, Fischer-Rosinsky, Antje, Zhao, Jing Hua, Sethupathy, Praveen, Pattou, François, Lajunen, Taina, Serrano-Ríos, Manuel, Walker, Mark, Zillikens, M Carola, Borecki, Ingrid B, Rotimi, Charles N, Doney, Alex S F, Shields, Beverley, Melzer, David, Vitart, Veronique, Elliott, Katherine S, Uda, Manuela, McAteer, Jarred B, Scuteri, Angelo, Isomaa, Bo, Prokopenko, Inga, Rice, Kenneth, Bergmann, Sven, Hofmann, Oliver M, Lu, Lingyi, Dupuis, Josée, Pfeiffer, Andreas F H, Hunter, David J, Sparsø, Thomas, Mukherjee, Sutapa, Sladek, Robert, Uitterlinden, Andre, Martínez-Larrad, María Teresa, Morris, Andrew P, Crisponi, Laura, Chines, Peter S, Morris, Andrew D, Hitman, Graham A, Henneman, Peter, Silveira, Angela, Rotter, Jerome I, Visvikis-Siest, Sophie, Welch, Ryan P, Böttcher, Yvonne, Thorand, Barbara, Pedersen, Nancy L, Sale, Michele M, Lewis, Joshua P, Brunner, Eric, Forouhi, Nita G, Knight, Beatrice, Wilson, James F, Adeyemo, Adebowale, Li, Yun, Palmer, Lyle J, Grarup, Niels, McCarroll, Steven A, Shields, Beverley M, Gyllensten, Ulf, van Dam, Rob M, Chen, Yii-Der Ida, Potter, Simon C, Crawford, Gabe, Dehghan, Abbas, Ferreira, Teresa, Goodarzi, Mark O, Perola, Markus, Ruokonen, Aimo, Hercberg, Serge, Kesaniemi, Y Antero, Witteman, Jaqueline C M, Delplanque, Jerome, Shuldiner, Alan R, Rayner, Nigel W, Waterworth, Dawn M, Sampson, Michael J, Polasek, Ozren, Koskinen, Seppo, van Herpt, Thijs, Charpentier, Guillaume, Graessler, Jürgen, Posthuma, Danielle, Borch-Johnsen, Knut, Wild, Sarah H, Deloukas, Panos, Jackson, Anne U, Randall, Joshua, Grundy, Scott, Stumvoll, Michael, Karpe, Fredrik, Hofman, Albert, Li, Man, Oostra, Ben A, Schlessinger, David, Illig, Thomas, Meitinger, Thomas, Cooke, Jessica N, Coin, Lachlan J M, Franks, Paul W, Laakso, Markku, Kanoni, Stavroula, Day, Ian N M, Lathrop, G Mark, Heath, Simon C, Burtt, Noël P, Wheeler, Eleanor, Roh, Bong H, Ariyurek, Yavuz, Altshuler, David, Bornstein, Stefan R, Griffin, Simon, Spector, Timothy D, Mohlke, Karen L, Luan, Jian'an, Stringham, Heather M, Beilby, John P, Walters, G Bragi, Tichet, Jean, Doney, Alex, Swift, Amy J, Stein, Lincoln D, Jørgensen, Torben, Hveem, Kristian, Ebrahim, Shah, Midthjell, Kristian, Spranger, Joachim, Guiducci, Candace, Lieverse, Aloysius, Witteman, Jacqueline, Bumpstead, Suzannah, Ferrara, Assiamira, Kaakinen, Marika, Sigurdsson, Gunnar, Robertson, Neil R, Hu, Frank B, Cornelis, Marilyn, Campbell, Harry, Bouatia-Naji, Nabila, Kivimaki, Mika, Narisu, Narisu, Bonnefond, Amélie, Naitza, Silvia, Langenberg, Claudia, Voight, Benjamin F, Bennett, Amanda J, Hicks, Pamela J, Gwilliam, Rhian, Magnusson, Patrik K E, Ferrucci, Luigi, Psaty, Bruce M, Nilsson, Peter, Ng, Maggie C Y, Sijbrands, Eric J G, Ward, Kim L, Florez, Jose C, Wagner, Peter J, Talbert, Matthew E, Roden, Michael, Swift, Amy, Roccasecca, Rosa Maria, Pouta, Anneli, Lindgren, Cecilia M, Kao, W H Linda, Wareham, Nicholas J, Meneton, Pierre, Shrader, Peter, Wing, Maria R, Zeggini, Eleftheria, Green, Todd, Palmer, Colin N A, Rivadeneira, Fernando, Franklin, Christopher S, Grallert, Harald, Manning, Alisa K, Willemsen, Gonneke, Freedman, Barry I, Zabena, Carina, Daly, Mark J, Rudock, Megan E, Rathmann, Wolfgang, Clarke, Robert, Sun, Qi, Scott, Laura J, Benediktsson, Rafn, Peltonen, Leena, Mangino, Massimo, Scheet, Paul, Boehnke, Michael, Mitchell, Braxton D, Sandhu, Manjinder, Varma, Dhiraj, Boström, Kristina Bengtsson, Thorsteinsdottir, Unnur, Steinthorsdottir, Valgerdur, Pichler, Irene, Hassanali, Neelam, Silander, Kaisa, Shriner, Daniel, Rolandsson, Olov, Lecoeur, Cécile, Zhai, Guangju, Chines, Peter, Egan, Josephine M, Meigs, James B, Rayner, N William, Meyre, David, Johnson, Paul R V, Saxena, Richa, Frayling, Timothy M, Nathan, David M, Pattaro, Cristian, Marre, Michel, Boomsma, Dorret I, Vogelzangs, Nicole, Smith, Nicholas L, Peden, John F, Payne, Felicity, Ganser, Martha, Lyssenko, Valeriya, Bravenboer, Bert, Proença, Christine, Rudan, Igor, Stefansson, Kari, Hattersley, Andrew T, Smith, George Davey, An, S Sandy, Simpson, Laila, Abecasis, Goncalo R, Kovacs, Peter, Vollenweider, Peter, Kraft, Peter, Ben-Shlomo, Yoav, Huth, Cornelia, Frants, Rune, Soranzo, Nicole, Hayward, Caroline, Wijmenga, Cisca, Weedon, Michael N, Schwarz, Peter, Mägi, Reedik, van Vliet-Ostaptchouk, Jana V, Johnson, Toby, Lauritzen, Torsten, Zelenika, Diana, Lawlor, Debbie A, Neville, Matthew J, Syddall, Holly, Willer, Cristen J, Gieger, Christian, Siscovick, David S, Ziegler, Julie T, Watanabe, Richard M, Hester, Jessica M, Walley, Andrew, Hottenga, Jouke Jan, Penninx, Brenda W J H, Hui, Jennie, Herder, Christian, Kuusisto, Johanna, Bonnycastle, Lori L, Thorleifsson, Gudmar, McDonough, Caitrin W, An, Ping, Mahley, Robert, Barter, Philip, Hide, Winston A, Elliott, Amanda, Sharp, Stephen J, Watkins, Hugh, Pankow, James S, Buchanan, Thomas A, Valle, Timo T, Segrè, Ayellet V, O'Connell, Jeffrey, Couper, David J, Hung, Joe, Bergman, Richard N, Fedson, Annette C, Morken, Mario A, Balkau, Beverley, McPherson, Ruth, Cao, Antonio, Tanaka, Toshiko, Song, Kijoung, Glazer, Nicole L, Rybin, Denis, Elliott, Amanda L, Orrù, Marco, Hansen, Torben, Dina, Christian, Hingorani, Aroon D, Sovio, Ulla, Aulchenko, Yurii S, Jula, Antti, Perry, John R B, van Hoek, Mandy, Pramstaller, Peter P, Froguel, Philippe, Province, Michael A, Gloyn, Anna L, Platou, Carl, Cooper, Cyrus, Petersen, Ann-Kristin, Sayer, Avan Aihie, Paolisso, Giuseppe, van Duijn, Cornelia M, Hadjadj, Samy, Groop, Leif, Ripatti, Samuli, Galan, Pilar, Erdos, Michael R, Bumpstead, Suzannah J, Tuomilehto, Jaakko, Hamsten, Anders, Fox, Caroline S, Tuomi, Tiinamaija, Sandbaek, Annelli +389 morecore +1 more sourceMulti-omic characterization of air pollution effects: Applications of AirSigOmniTWP Hub
Ecotoxicology and Environmental SafetyAir pollution, particularly fine particulate matter and gaseous pollutants including NO2 and NOx, presents significant public health challenges. While the harmful effects of these pollutants are well-documented, the molecular mechanisms underlying their ...Wei Liu, Tong Liu, Xinxin Si, Jiaxing Liang, Xia Yan, Juexin Zhang, Bing Pang, Wenmin Luo, Junhong Liu, Huazhe Yang, Peng Shi +10 moredoaj +1 more sourceF7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling
Advanced Science, EarlyView.ABSTRACT
Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen +9 morewiley +1 more sourceMethylome-wide association studies and epigenetic biomarker development for 133 mass spectrometry-assessed circulating proteins in 14,671 Generation Scotland participants
Genome BiologyBackground DNA methylation (DNAm) can regulate gene expression, and its genome-wide patterns (epigenetic scores or EpiScores) can act as biomarkers for complex traits. The relative stability of methylation profiles may enable better assessment of chronic Josephine A. Robertson, Jakub Bajzik, Spyros Vernardis, Aleksandra D. Chybowska, Daniel L. McCartney, Arturas Grauslys, Jure Mur, Hannah M. Smith, Archie Campbell, Camilla Drake, Hannah Grant, Jamie Pearce, Tom C. Russ, Poppy Adkin, Matthew White, Charles Brigden, Christoph B. Messner, David J. Porteous, Caroline Hayward, Simon R. Cox, Aleksej Zelezniak, Markus Ralser, Matthew R. Robinson, Riccardo E. Marioni +23 moredoaj +1 more source
