Results 261 to 270 of about 260,383 (299)

Identification of Protein Markers for Chronic Ischemic Heart Disease Through Integrated Analysis of the Human Plasma Proteome and Genome-Wide Association Data. [PDF]

Proteomes
Ren C, Qiao G, Wu J, Lu Y, Liu M, Zhang C.   +5 more
europepmc   +1 more source

Proteome-wide and network pharmacology integration identifies sunitinib as a potential therapeutic for type 2 diabetes targets. [PDF]

Ther Adv Endocrinol Metab
Kong Y, Zhu HW, Tong HX, Shi L, Yu H.
europepmc   +1 more source

Uncovering potential therapeutic targets for autoimmune hepatitis using proteome-wide Mendelian randomization. [PDF]

Medicine (Baltimore)
Li C, Liu T, Zhou L, Chen J, Wei Z, Li J.   +5 more
europepmc   +1 more source

Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals

Richmond A, Robertson JA, Smith HM, Hillary RF, Zelezniak A, Vernardis S, Chybowska AD, Grauslys A, Mur J, Campbell A, Drake C, Grant H, Adkin P, White M, Brigden C, Messner CB, Porteous DJ, Hayward C, McIntosh AM, McCartney DL, Ralser M, Marioni RE.   +21 more
europepmc   +1 more source

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Proteome‐wide association study using cis and trans variants and applied to blood cell and lipid‐related traits in the Women's Health Initiative study

Genetic Epidemiology
In most Proteome‐Wide Association Studies (PWAS), variants near the protein‐coding gene (±1 Mb), also known as cis single nucleotide polymorphisms (SNPs), are used to predict protein levels, which are then tested for association with phenotypes. However,
Brian D Chen, Chanhwa Lee, Amanda L. Tapia, Alexander P. Reiner, Hua Tang, C. Kooperberg, Joann E Manson, Yun Li, L. Raffield   +8 more
semanticscholar   +1 more source

Abstract 1716: A proteome-wide association study identifies putative causal proteins for breast cancer

Cancer Research
Background: Genome-wide association studies (GWAS) have identified over 200 breast cancer risk associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive.
Tianying Zhao, Shuai Xu, J. Ping, G. Jia, Yongchao Dou, Bing Zhang, Xingyi Guo, Q. Cai, X. Shu, W. Zheng, J. Long   +10 more
semanticscholar   +1 more source

Abstract 6153: Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma

Cancer Research
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy, largely due to the paucity of reliable biomarkers for early detection and therapeutic targeting.
Jingjing Zhu, Ke Wu, Shuai Liu, Alexandra Masca, Hua Zhong, Tai Yang, Dalia H. Ghoneim, Praveen Surendran, Tanxin Liu, Q. Yao, Tao Liu, S. Fahle, Adam Butterworth, M. A. Alam, J. Vadgama, Youping Deng, Hong-Wen Deng, Chong Wu, Yong Wu, Lang Wu   +19 more
semanticscholar   +1 more source

Blood plasma proteome-wide association study implicates new proteins in type 2 diabetes mellitus pathogenesis.

Journal of Clinical Endocrinology and Metabolism
The pathophysiological mechanisms underlying type 2 diabetes mellitus (T2DM) remain incompletely understood, and the disease continues to impose a substantial burden on global health.
Yang Yang, Jia-Hao Wang, Hao-An Wang, Tian-Pei Zhang, Guanchen Liu, Shanshan Dong, Tie-Lin Yang, Wei Chen, Ruo-Han Hao, Yan Guo   +9 more
semanticscholar   +1 more source

Proteome-wide Association Study Provides Insights Into the Genetic Component of Protein Abundance in Psychiatric Disorders

Biological Psychiatry, 2021
Jie-wei Liu, Xiaoyan Li, Xiongjian Luo
semanticscholar   +1 more source

F14. PROTEOME WIDE ASSOCIATION STUDY OF MAJOR DEPRESSIVE DISORDER, SCHIZOPHRENIA, AND BIPOLAR DISORDER

European Neuropsychopharmacology, 2023
Laurence Nisbet
semanticscholar   +1 more source