Results 51 to 60 of about 115,149 (302)

Nejire/dCBP-mediated control of H3 acetylation and transcriptional regulation by testis-specific Plus3 domain proteins during Drosophila spermatogenesis [PDF]

, 2018
Spermatogenesis describes the development from germ line stem cells to highly specialized sperm. Drosophila melanogaster spermatogenesis is a good model system for chromatin remodelling processes as many of these processes are similar in mammals and in ...
Hundertmark, Tim
core   +1 more source

Identification of potential changes in protein abundance associated with post-traumatic stress disorder through brain proteome-wide association study [PDF]

Abstract Aim Post-traumatic stress disorder (PTSD) is a common mental disorder with a substantial genetic background. Recent genome-wide association analysis (GWAS) has identified 95 genome-wide significant (GWS) loci in a large cross-ancestry cohort comprising over 1 million samples. However, bridging the GWS
Jiewei Liu, Zhongchun Liu
openalex   +2 more sources

Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin [PDF]

, 2018
This work was funded by the Neonatal Unit Endowment Fund, Aberdeen Maternity Hospital. RH is funded by a career researcher fellowship from NHS Research Scotland. SG was funded by the MRC Flagship PhD programme.
Berry, Susan, Collie-Duguid, Elaina S. R., De Paiva Alves, Eduardo, El-Omar, Emad, Gibson, Sophie, Goddard, Mark, Hansen, Richard, Hold, Georgina L., Karcher, Anne Marie, MacLaren, Andrew, Munro, Mike   +10 more
core   +4 more sources

A genetic correlation scan identifies blood proteins associated with bone mineral density

BMC Musculoskeletal Disorders, 2022
Background Osteoporosis is a common metabolic bone disease that is characterized by low bone mass. However, limited efforts have been made to explore the functional relevance of the blood proteome to bone mineral density across different life stages ...
Jiawen Xu, Shaoyun Zhang, Haibo Si, Yi Zeng, Yuangang Wu, Yuan Liu, Mingyang Li, Limin Wu, Bin Shen   +8 more
doaj   +1 more source

Proteomic Analysis to Identify Tightly-Bound Cell Wall Protein in Rice Calli. [PDF]

, 2015
Rice is a model plant widely used for basic and applied research programs. Plant cell wall proteins play key roles in a broad range of biological processes. However, presently, knowledge on the rice cell wall proteome is rudimentary in nature.
Chen, Xiong Yan, Cho, Won Kyong, Hyun, Tae Kyung, Jo, Yeonhwa, Kim, Jae-Yean, Kim, Suwha, Kumar, Dhinesh, Lee, Keun Woo, Lucas, William J, Park, Zee-Yong, Rim, Yeonggil   +10 more
core   +1 more source

Biases in the Experimental Annotations of Protein Function and their Effect on Our Understanding of Protein Function Space [PDF]

, 2013
The ongoing functional annotation of proteins relies upon the work of curators to capture experimental findings from scientific literature and apply them to protein sequence and structure data.
Babbitt, Patricia, Babbitt, PC, Friedberg, I, Ream, DC, Schnoes, AM, Thorman, AW   +5 more
core   +4 more sources

Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies

Frontiers in Medicine
IntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated.
Zhe Zhang, Zhe Zhang, Yu Chen, Qianjin Wang, Zheng Li, Bingyang Dai, Bingyang Dai, Cheng Dong, Cheng Dong, Zhengya Zhu   +9 more
doaj   +1 more source

Causal associations between severe COVID-19 and diseases of seven organs: a proteome-wide mendelian randomization study [PDF]

Frontiers in Genetics
The coronavirus disease 2019 (COVID-19) pandemic poses an enormous threat to public health worldwide. Many retrospective studies and case reports to date have shown associations between severe COVID-19 and diseases of multi-organs. However, the research on the causal mechanisms behind this phenomenon is neither extensive nor comprehensive. We conducted
Yunhang Shen, Yi Zhang, Yeyang Xu, Xinyi Li, Jiachen Wu, Pei Hao, Linyan Wang, Tiansheng Zhu   +7 more
openalex   +4 more sources

EPMA position paper in cancer:current overview and future perspectives [PDF]

, 2015
At present, a radical shift in cancer treatment is occurring in terms of predictive, preventive, and personalized medicine (PPPM). Individual patients will participate in more aspects of their healthcare.
Bubnov, Rostylav, Danesi, Romano, Desiderio, Dominic M., Grech, Godfrey, Hagan, Suzanne, Vittadini, Giorgio, Yoo, Byong Chul, Zhan, Xianquan   +7 more
core   +5 more sources

Recessive effects in cancer predisposition exposed by genome-wide and proteome-wide association studies [PDF]

, 2020
AbstractThe characterization of germline genetic variation affecting cancer risk, known as cancer predisposition, is fundamental to preventive and personalized medicine. Current attempts to detect cancer predisposition genomic regions are typically based on small-scale familial studies or genome-wide association studies (GWAS) over dedicated case ...
Nadav Brandes, Nathan Linial, Michal Linial   +2 more
openaire   +1 more source