Results 31 to 40 of about 41,903,721 (265)
Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma. [PDF]
GigascienceAbstract Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy, largely due to the paucity of reliable biomarkers for early detection and therapeutic targeting. Existing blood protein biomarkers for PDAC often suffer from replicability issues, arising from inherent limitations such as ...Zhu J, Wu K, Liu S, Masca A, Zhong H, Yang T, Ghoneim DH, Surendran P, Liu T, Yao Q, Liu T, Fahle S, Butterworth A, Alam MA, Vadgama JV, Deng Y, Deng HW, Wu C, Wu Y, Wu L. +19 moreeuropepmc +3 more sourcesProteome Wide Association Studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease
Alzheimer's & Dementia, 2023 AbstractBackgroundLeucine‐rich repeat kinase 2 (LRRK2) common gene variants (tagged by rs76904798) are associated with Parkinson’s disease (PD) risk. In a previous study, we found that rs76904798 was associated with CSF GRN levels, but a comprehensive unbiased analysis of associated proteins remains incomplete due to prior focus on cis‐protein ...Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga +26 moreopenaire +5 more sourcesA Proteome-Wide Association Study Identified Candidate Human Brain Proteins Associated with Coffee Consumption
, 2021 Abstract Background Increasing evidence suggests the association between caffeine and the brain and nervous system. However, there is limited research on the genetic associations between coffee consumption subtypes and brain proteome, plasma proteomes, and peripheral metabolites. Methods First, proteome-wide association study (PWAS) of coffee Chun'e Li, Xiao Liang, Yumeng Jia, Yan Wen, Huijie Zhang, Shiqiang Cheng, Chuyu Pan, Jingxi Zhang, Zhen Zhang, Yujing Chen, Xuena Yang, Peilin Meng, Yao Yao, Feng Zhang, Cuiyan Wu, Sen Wang, Yujie Ning, Xi Wang +17 moreopenaire +1 more sourceGenome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension [PDF]
, 2010 Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%–2% of the population variation in BP and hypertension.Zanchetti A, Wichmann HE, Samani, NJ, Munroe, P., Navis G, P. Sever (7602536), Hastie, Claire E., A. H. Baker (7611224), Martina Montagnana, McDonald, Robert A., Wahlstrand, B, Kathiresan, S., Snieder, Harold; id_orcid, Völzke Henry, Ruth J. F. Loos, Nicklin, SA, Morris Brown, Nolte IM, Wichmann, H.-E., Kathiresan S, Padmanabhan Sandosh, Zhang Feng, M. Montagnana (7611173), Caulfield MJ, Rettig Rainer, Laan, Maris, Rettig, Rainer, J. Luan (7609367), Mc Donald, R.A., Melander, Olle,, Peter Vollenweider, Sever, P, Nicklin Suart, A., Zanchetti, A., Hedblad, Bo, Ole Torffvit, A. Teumer (7609454), Stewart Laing, Hastie, CE, P. Welsh (7611230), M. Burnier (7611161), Bochud, Murielle, Miller, WH, Wichmann, H.E., Martin Farrall, Montagnana M, Caulfield Mark J., M. C. Monti (7611146), J. P. Pell (6240134), Michel Burnier, Eyheramendy, S., Maris Laan, David P Strachan, Snieder Harold, Connell JMC, Vollenweider Peter, Connell, JMC, Signorini S, Zhang, F, Newton-Cheh Christopher, Laing, Stewart, M. Farrall (6522599), Stanton Alice, Timothy D Spector, Mark J. Caulfield, Sattar, N, B. Corso (7611152), Gentilini D, Kwakernaak, A.J., McDonald RA, Penninx Brenda W., W. H. Miller (7611218), Spector Timothy, D., Conell, J.M.C., Fava, Cristiano,, Shields, D.C., Kjeldsen, S, Samani Nilesh, J., Strachan, David P., Corso, B., Timothy D. Spector, Montagnana Martina, Pell JP, Nicklin Stuart A., D. S. Siscovick (7611209), Welsh, P., Johnson, T, Connell, John M. C., Johnson, T., Naveed Sattar, Sjögren, M, Bochud Murielle, Torffvit, O, Sever Peter, Kjeldsen Sverre, G. Grassi (2592760), Navis, G., Laan, M., Padmanabhan S, Johnson T, S. Laing (7611149), Nolte Ilja, M., C. Delles (7602479), Jill P. Pell, Miller William H., Shields Denis, Colm, Lucas, Gavin, Dominiczak A.F., Connell John M. C., Snieder, H, Mark J Caulfield, Snieder H, Caulfield, M.J., A. J. Kwakernaak (3694963), Newton Cheh C, Stuart A. Nicklin, Connell John, M.C., Wahlstrand, Björn, Hedblad, Bo,, Newton-Cheh C, Brown, M., Laing S, Montagnana, Martina,, Brown Morris, Hedner, Thomas, Wareham, N.J., A. M. Di Blasio (7611140), Graham, D, Miller, W.H., Nicholas J Wareham, Rettig R, David S Siscovick, Nicholas J. Wareham, Nolte, Ilja M., F. Zhang (2167666), David S. Siscovick, Loos, Ruth J. F., McDonald Robert, A., Burnier, M, G. Mancia (7611191), Nolte Ilja M., Arora, Pankaj, Murielle Bochud, Cristina Menni, Loos, RJF, Cesana Giancarlo, Sjögren, Marketa, Baker, Andrew H., Nolte, Ilja M.; id_orcid, Welsh P, Lund University., van der Harst, Pim, Welsh, P, Monti Maria Cristina, Völzke, H, Bochud M, Sever, Peter, Baker, AH, Hedner Thomas, van der Harst, Pim; id_orcid, Maillard, Marc, Torffvit, O., Stanton, A, Wareham NJ, Kjeldsen, Sverre, Wahlstrand B, Lee, WK, B. Hedblad (7611182), S. Kathiresan (7606013), Brenda W Penninx, Spector Timothy D., Lee, W.K., Teumer, A., Toby Johnson, McBride, M, Menni Cristina, Fava Cristiano, Pim van der Harst, Penninx, Brenda W., Susana Eyheramendy, Wareham, NJ, Connell, John M.C., Teumer, A, Barbara Corso, Melander, O, Wareham Nicholas, J., Penninx, B.W., Ruth J F Loos, Claire E Hastie, Shields, Denis Colm, Alberto Zanchetti, Peter Sever, Lee Wai K., Torffvit Ole, Delles, C, Luan, J., Cristiano Fava, McBride Martin, Mancia, G., Gavin Lucas, Shields DC, Luan, Jian'an, Zhang, Feng, Arora Pankaj, Björn Wahlstrand, John M C Connell, Newton-Cheh, C, Wareham, Nicholas J., Cesana, Giancarlo, Snieder, Harold, Melander Olle, Eyheramendy, Susana, Di Blasio, A.M., Torffvit, Ole, McBride, Martin, Maillard Marc, Corso B, Schork, Nicholas J., van der Harst Pim, Nolte, IM, T. Johnson (7602368), Teumer Alexander, D. Graham (29758), Loos Ruth, J.F., Monti Maria, Cristina, Hastie Claire E., S. A. Nicklin (7611221), M. Bochud (7611158), Kwakernaak Arjan, J., Global BPgen Consortium (7611233), Sjögren M, Voelzke, Henry, Vollenweider, P, Delles, Christian, Monti, M.C., Stanton, A., Grassi, G, Grassi, G., van der Harst P, Strachan, DP, Eyheramendy Susana, Soranzo Nicole, Danese Elisa, Gentilini, D, Fava, C, Hedner, T, Spector, TD, Navis, G, B. W. Penninx (7611212), Luan, JA, Connell JM, M. Maillard (3464312), Delles Christian, Luan, Jian'an, Montagnana, Martina, Pell, JP, Hastie CE, Eyheramendy S, Robert A. McDonald, Menni C, Luan J, Anna F Dominiczak, Connell, JM, Caulfield, Mark J., Di Blasio, AM, Burnier, M., Monti, MC, Siscovick David, S., Kwakernaak, Arjan J., Signorini, Stefano, Henry Völzke, Stuart A Nicklin, van der Harst, P, Loos RJ, Hedblad B, Strachan David P., Nolte, I.M., Pell Jill P., Burnier, Michel, Munroe P, W. K. Lee (7602476), H Erich Wichmann, null null, Ilja M. Nolte, Giuseppe Mancia, Monti, Maria Cristina, Menni, C, Farrall Martin, Brown, M, Montagnana, M., Samani, Nilesh J., Nilesh J. Samani (7579793), S. Signorini (7611194), McDonald, R.A., Farrall, M, Anna Maria Di Blasio, T. D. Spector (7608968), Baker Andrew H., Sever P, Loos RJF, Penninx Brenda, W., Vollenweider, P., Marc Maillard, Sattar Naveed, Wahlstrand Björn, John M. C. Connell, Newton-Cheh, Christopher, Kwakernaak AJ, Soranzo, N, Bochud, M., M. Laan (7602659), Fava C, Penninx, BW, Sattar, Naveed, Kjeldsen S, Snieder, H., Martin McBride, Graham Delyth, Vollenweider P, G. Cesana (7611188), Mancia G, Brenda W. Penninx, O. Torffvit (7611179), D. P. Strachan (3809152), Newton-Cheh, C., A. Stanton (7611200), R. J. Loos (7608845), McDonald, RA, Danese, E., David P. Strachan, Nicklin SA, William H. Miller, Siscovick, DS, M. Sjögren (7611167), Pell, Jill P., Arora P, C. E. Hastie (7602473), H. Snieder (7611185), Signorini, S, McDonald Robert A., Ilja M Nolte, Dominiczak Anna, F., Miller, William H., Cesana, G, Stefano Signorini, Guido Grassi, I. M. Nolte (3809176), Samani, N.J., Wichmann H. Erich,, D. Gentilini (4402804), Kathiresan, S, Gerjan Navis, Harold Snieder, Samani NJ, Rettig, R, Feng Zhang, Baker, A.H., Siscovick David S., P. van der Harst (7594607), Pell Jill, P., Burnier Michel, Soranzo, N., Dominiczak, A.F., Mancia Giuseppe, Padmanabhan, Sandosh, Torffvit O, Gentilini, Davide, Völzke, Henry, Stanton A, Di Blasio Anna, Maria, van der Harst, P., Wichmann, HE, H. Erich Wichmann, Lucas, G, Mancia, G, Zanchetti, A, Mancia, Giuseppe, M. McBride (7611215), Elisa Danese, Zhang, F., Fava, Cristiano, Denis Colm Shields, Feng, Zhang, Menni, C., Laing, S., Global BPgen Consortium, Andrew H Baker, Thomas Hedner, P. Munroe (7609094), Spector, Timothy D., C. Newton-Cheh (7602563), Lee WK, Munroe, Patricia, Delyth Graham, Torffvit, Ole,, Delles, C., Hedblad, B, Sverre Kjeldsen, Wahlstrand, B., Robert A McDonald, Sjögren Marketa, Grassi G, N. Sattar (7608890), Farrall, M., O. Melander (7602683), Teumer, Alexander, Olle Melander, Dominiczak, Anna F., Kwakernaak Arjan J., Di Blasio Anna Maria, Navis Gerjan, D. C. Shields (7602542), Laan, M, Kwakernaak A, Laing Stewart, Zanchetti Alberto, Zhang F, Cesana, G., G. Navis (7611155), Siscovick, David S., C. Fava (7611170), Pell, J.P., Munroe Patricia, Siscovick DS, Melander O, Jill P Pell, Nilesh J. Samani, Strachan, D.P., Corso Barbara, Fava, C., Lucas Gavin, Maillard, M, Lucas G, N. Soranzo (7608857), Baker Andrew, H., Hastie, C.E., Sever, P., Farrall, Martin, Laan M, Hedner, T., Davide Gentilini, Corso, B, Samani Nilesh J., S. Padmanabhan (637530), Giancarlo Cesana, Stanton, Alice, Shields Denis Colm, William H Miller, Graham, Delyth, Völzke H, Sekar Kathiresan, Hedblad Bo, Danese, Elisa, Bo Hedblad, Maillard M, Miller William, H., Melander, O., Montagnana, M, Vollenweider, Peter, Burnier M, T. Hedner (7602677), Wareham Nicholas J., Wai K Lee, A. Zanchetti (7611236), Soranzo, Nicole, P. Arora (7611206), Völzke, H., Andrew H. Baker, Connell, J.M.C., Johnson, Toby, Miller WH, Strachan David, P., Sattar, N., C. Menni (7611143), B. Wahlstrand (7602680), Di Blasio AM, Sattar N, Rettig, R., Signorini Stefano, Christian Delles, Arjan J Kwakernaak, Luan Jian'an, Siscovick, D.S., Harst, Pim van der, H. Völzke (6643736), Marketa Sjögren, Danese, E, Hastie Claire, E., Monti MC, Penninx BW, Lee Wai, K., Caulfield, MJ, Christopher Newton-Cheh, Harst, P. van der, Dominiczak, AF, Arjan J. Kwakernaak, Caulfield Mark, J., Nicole Soranzo, J. M. Connell (7602551), Johnson Toby, Gentilini, D., Loos, RJ, Rainer Rettig, Anna F. Dominiczak, Loos Ruth J. F., G. Lucas (7606529), Padmanabhan, S, Teumer A, Brown, Morris, Bochud, M, Dominiczak Anna F., S. Eyheramendy (7611197), Wichmann, Heinz-Erich, Grassi, Guido, Hedblad, B., Alexander Teumer, Hedner T, Munroe, P, Wai K. Lee, Luan, J, M. Brown (3020991), Luan JA, Danese E, Welsh, Paul, Laing, S, Welsh Paul, Spector TD, Pankaj Arora, Patricia Munroe, Newton Cheh, Christopher, Maria Cristina Monti, Melander, Olle, Delles C, Graham D, H. E. Wichmann (7608932), Padmanabhan, S., R. A. McDonald (7611227), A. F. Dominiczak (7602482), Spector, T.D., Kwakernaak, AJ, Baker AH, Loos, R.J.F., Zanchetti, Alberto, Navis, Gerjan, Sjögren, Marketa,, Graham, D., Wichmann, H. Erich, Claire E. Hastie, Farrall M, N. J. Wareham (7608962), Eyheramendy, S, Kathiresan, Sekar, M. J. Caulfield (7602383), Nicklin, S.A., P. Vollenweider (4002164), Gentilini Davide, S. Kjeldsen (7611164), Arora, P, E. Danese (7611176), Sjögren, M., Laan Maris, Nicklin, Stuart A., Menni, Cristina, Signorini, S., Gentilini, G., Arora, P., Alice Stanton, Dominiczak AF, R. Rettig (7611203), Kathiresan Sekar, Paul Welsh, Maillard, M., Soranzo N, Corso, Barbara, Cesana G, Sandosh Padmanabhan, Di Blasio, Anna Maria, Jian'an Luan, Grassi Guido, McBride, M., Strachan DP, Shields, DC, Wichmann H. Erich, Lee, Wai K., Nilesh J Samani, Brown M, Lucas, G., Luan, J.A., McBride M, Kjeldsen, S., Bjo rn Wahlstrand, Christopher NewtonCheh, Marketa Sjo gren, Henry Vo lzke, Blasio, A.M. di +594 morecore +1 more sourceGenome-wide association study of receptive language ability of 12 year olds [PDF]
, 2013 Purpose: We have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. The current study attempted to identify some of the genes responsible for the heritability of receptive language ...Hanscombe, K.B., Meaburn, Emma L, Dale, Philip S, Plomin, Robert, Hayiou-Thomas, Marianna E, Jankowski, Janusz, Haworth, Claire M.A., Trzaskowski, M., Haworth, C., Haworth, Claire M. A., Hayiou-Thomas, Marianna E., Wellcome Trust Case Control Consortium (including Jankowski J), Harlaar, N., Haworth, Claire M A, Dale, Philip S., Dale, P., Harlaar, Nicole, Price, T.S, Price, Thomas S, Docherty, Sophia, Hayiou-Thomas, M.E., Davis, Oliver S. P., Plomin, R., Meaburn, Emma L., Price, Tom S., HASH(0x55a67fe4f3e8), Hanscombe, Ken B., ?, ?, Davis, O.S.P., Docherty, S.J., Price, Thomas S., Trzaskowski, Maciej, Davis, Oliver S P +32 morecore +1 more sourceIntegrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence
Journal of Addiction Medicine, 2022 Objectives Alcohol dependence accounts for a large proportion of the global burden of disease and disability. This study aims to investigate the candidate genes and chemicals associated with alcohol dependence. Methods Using data from published alcohol dependence genome-wide ...Zhang, Jingxi, Meng, Peilin, Yao, Yao, Zhang, Huijie, Pan, Chuyu, Li, Chun'e, Chen, Yujing, Zhang, Zhen, Cheng, Shiqiang, Liu, Li, Yang, Xuena, Jia, Yumeng, Zhang, Feng +12 moreopenaire +2 more sourcesGenome-Wide Association Study of Major Depressive Disorder: New Results, Meta-Analysis, and Lessons Learned [PDF]
, 2010 Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imputed single-nucleotide polymorphisms (SNPs)). D I Boomsma, Sullivan, P.F., Sullivan, P F, G Willemsen, D J Statham, Willemsen, G.; id_orcid, Gordon, SD, Penninx, BWJH, Smit, J H, Medland, S E, Maclean, A.W., S E Medland, Penninx, B. W. J. H., van den Oord, E J C G, Montgomery, G W, Pergadia, M L, Byrne, E.M., Heath, A.C., Martin, N.G., MacIntyre, Donald; id_orcid, Hickie, I.B., Statham, D.J., C M Middeldorp, E M Byrne, B W J H Penninx, Nyholt, D.R., J J Hottenga, J H Smit, A K Henders, Blackwood, D.H., Liu, J. Z., N G Martin, A W Maclean, Lewis, C.M., Montgomery, G. W., McGuffin, P, S D Gordon, McEvoy, B.P., MacIntyre, D J, McGhee, K A, P A F Madden, MacIntyre, D J; id_orcid, Pergadia, M. L., van den Oord, E.J., McEvoy, B P, Gordon, S.D., Martin, N. G., D H R Blackwood, P F Sullivan, De Geus, E. J. C., Montgomery, G.W., Hottenga, J.J., Hickie, I. B., McGhee, K.A., Medland, S. E., C M Lewis, J Z Liu, Gordon, S D, Smit, J. H., Boomsma, D. I., Hottenga, J. J., Smit, J.H., Middeldorp, C.M., Ripke, S., M L Pergadia, Hickie, I B, de Geus, E.J., Wray, NR, Van Den Oord, E. J. C. G., Wray, N. R., Blackwood, DHR, de Geus, E J C, Penninx, B.W., B P McEvoy, McGhee, K. A., Middeldorp, C. M., Byrne, E. M., McEvoy, B. P., Macgregor, S, E J C G van den Oord, Statham, D J, Heath, A C, Lewis, C. M., van den Oord, E.J.C.G., I B Hickie, Willemsen, G., Pergadia, M.L., Medland, S.E., Sullivan, P. F., Penninx, B.W.J.H., Heath, A. C., Maclean, AW, Nyholt, D. R., N R Wray, S Macgregor, MacIntyre, DJ, Boomsma, D.I., G W Montgomery, Lewis, C M, Henders, A K, Madden, P. A. F., Madden, P.A.F., Henders, A.K., Hottenga, J J, McGuffin, P., Boomsma, D I, Madden, P.A., de Geus, E.J.C.; id_orcid, Henders, A. K., Wray, N R, Madden, P A F, E J C de Geus, Pergadia, ML, D R Nyholt, Maclean, A W, Ripke, S, A C Heath, Ripke, Stephan, MacIntyre, D. J., Blackwood, D. H. R., Statham, D. J., Penninx, B W J H, Gordon, S. D., McGhee, KA, D J MacIntyre, Nyholt, D R, Wray, N.R., Middeldorp, C M, Liu, J Z, S Ripke, K A McGhee, P McGuffin, Nyholt, DR, Willemsen, G, Boomsma, D.I.; id_orcid, Lewis, C. M.; id_orcid, Martin, N G, Blackwood, D H R, Liu, J.Z., Byrne, E M, MacIntyre, D.J., MacGregor, S., MacLean, A. W. +142 morecore +2 more sourcesIdentification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies
Frontiers in MedicineIntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated.Zhe Zhang, Zhe Zhang, Yu Chen, Qianjin Wang, Zheng Li, Bingyang Dai, Bingyang Dai, Cheng Dong, Cheng Dong, Zhengya Zhu +9 moredoaj +1 more source
