Results 31 to 40 of about 114,169 (274)

Proceedings of the EuBIC Winter School 2019 [PDF]

, 2019
The 2019 European Bioinformatics Community (EuBIC) Winter School was held from January 15th to January 18th 2019 in Zakopane, Poland. This year’s meeting was the third of its kind and gathered international researchers in the field of (computational ...
Bittremieux, Wout, Bouyssié, David, Dorfer, Viktoria, Kopczynski, Dominik, Locard-Paulet, Marie, Schwämmle, Veit, Soggiu, Alessio, Uszkoreit, Julian, Van Puyvelde, Bart, Willems, Sander   +9 more
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A Proteome-Wide Association Study Identified Candidate Human Brain Proteins Associated with Coffee Consumption

, 2021
Abstract Background Increasing evidence suggests the association between caffeine and the brain and nervous system. However, there is limited research on the genetic associations between coffee consumption subtypes and brain proteome, plasma proteomes, and peripheral metabolites. Methods First, proteome-wide association study (PWAS) of coffee
Chun'e Li, Xiao Liang, Yumeng Jia, Yan Wen, Huijie Zhang, Shiqiang Cheng, Chuyu Pan, Jingxi Zhang, Zhen Zhang, Yujing Chen, Xuena Yang, Peilin Meng, Yao Yao, Feng Zhang, Cuiyan Wu, Sen Wang, Yujie Ning, Xi Wang   +17 more
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Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children [PDF]

, 2015
Enteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases.
Guerrant, RL, Havt, A, Leite, Á, Lima, AAM, Lima, NL, Mayneris-Perxachs, J, Moore, SR, Moura, AF, Pinkerton, R, Soares, AM, Swann, JR   +10 more
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Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
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Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Alzheimer's & Dementia, 2023
AbstractBackgroundLeucine‐rich repeat kinase 2 (LRRK2) common gene variants (tagged by rs76904798) are associated with Parkinson’s disease (PD) risk. In a previous study, we found that rs76904798 was associated with CSF GRN levels, but a comprehensive unbiased analysis of associated proteins remains incomplete due to prior focus on cis‐protein ...
Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga   +26 more
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Proteomic Analysis to Identify Tightly-Bound Cell Wall Protein in Rice Calli. [PDF]

, 2015
Rice is a model plant widely used for basic and applied research programs. Plant cell wall proteins play key roles in a broad range of biological processes. However, presently, knowledge on the rice cell wall proteome is rudimentary in nature.
Chen, Xiong Yan, Cho, Won Kyong, Hyun, Tae Kyung, Jo, Yeonhwa, Kim, Jae-Yean, Kim, Suwha, Kumar, Dhinesh, Lee, Keun Woo, Lucas, William J, Park, Zee-Yong, Rim, Yeonggil   +10 more
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Proteome Profiling of Breast Tumors by Gel Electrophoresis and Nanoscale Electrospray Ionization Mass Spectrometry [PDF]

, 2008
We have conducted proteome-wide analysis of fresh surgery specimens derived from breast cancer patients, using an approach that integrates size-based intact protein fractionation, nanoscale liquid separation of peptides, electrospray ion trap mass ...
Aebersold R., Boyle E. I., Chong P. K., Cottingham K., Cove D. H., Ezeh U. I., Foran E., Gygi S. P., Ioachim E., Jacobs J. M., Keller A., Laemmli U. K., Lapillonne A., Lin C. S., Liu H., Maclean B., Mathelin C., Metodiev M. V., old W. M., Patterson S. D., Pedrioli P. G., Rauch A., Schmidt A., Sealfon R. S., Seo J., Sheen-Cheen S. M., Silva J., Taylor M. R., Toi M., Wolters D. A., Zhang J.   +30 more
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Integrative analysis of proteome-wide association and transcriptome-wide association study identifies candidate brain proteins associated with insomnia [PDF]

, 2021
Abstract Great progress has been made in identifying risk loci for insomnia by genome-wide association studies (GWAS) analysis, but its association with human brain proteome is unclear. Two insomnia GWAS summary datasets were derived from deCODE (n = 113,006) and 23andMe (n = 1,331,010). Two human brain proteomic datasets were obtained from ROS/
Peilin Meng, Bolun Cheng, Chun’e Li, Huijie Zhang, Shiqiang Cheng, Li Liu, Xuena Yang, Chujun Liang, Yao Yao, Jing Ye, Xiaomeng Chu, Chuyu Pan, Yujing Chen, Jingxi Zhang, Zhen Zhang, Yan Wen, Yumeng Jia, Xiong Guo, Feng Zhang   +18 more
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Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study [PDF]

Metabolism, 2023
Fibroblast growth factor 21 (FGF21) has demonstrated efficacy for reducing liver fat and reversing non-alcoholic steatohepatitis in phase 2 clinical trials. It is also postulated to have anti-fibrotic effects and therefore may be amenable to repurposing for the prevention and treatment of chronic kidney disease (CKD).We leverage a missense genetic ...
Giontella, Alice, Zagkos, Loukas, Geybels, Milan, Larsson, Susanna C., Tzoulaki, Ioanna, Mantzoros, Christos S., Andersen, Birgitte, Gill, Dipender, Cronjé, Héléne T.   +8 more
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Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus [PDF]

, 2018
Background: Systematic lupus erythematosus (SLE) is characterized with various complications which can cause serious organ damage in the human body. Despite the significant improvements in disease management of SLE patients, the non-invasive diagnosis ...
Burkly, L.C., Mischak, H., Mullen, W., Pejchinovski, M., Petri, M.A., Siwy, J., Wei, R.   +6 more
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