Results 21 to 30 of about 44,050 (232)

Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies [PDF]

HGG Advances, 2023
Summary: Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most ...
Daiwei Zhang, Boran Gao, Qidi Feng, Ani Manichaikul, Gina M. Peloso, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Stacey Gabriel, Namrata Gupta, Joshua D. Smith, Francois Aguet, Kristin G. Ardlie, Thomas W. Blackwell, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Laura J. Scott, Xiang Zhou, Seunggeun Lee   +21 more
doaj   +5 more sources

Plasma proteome analysis implicates novel proteins as potential therapeutic targets for chronic kidney disease: A proteome-wide association study [PDF]

Heliyon
Chronic kidney disease (CKD) is prevalent globally with limited therapeutic drugs available. To systemically identify novel proteins involved in the pathogenesis of CKD and possible therapeutic targets, we integrated human plasma proteomes with the ...
Yang Xiong, Tianhong Wang, Wei Wang, Yangchang Zhang, Fuxun Zhang, Jiuhong Yuan, Feng Qin, Xianding Wang   +7 more
doaj   +2 more sources

Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma. [PDF]

Gigascience
Abstract   Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy, largely due to the paucity of reliable biomarkers for early detection and therapeutic targeting. Existing blood protein biomarkers for PDAC often suffer from replicability issues, arising from inherent limitations such as ...
Zhu J, Wu K, Liu S, Masca A, Zhong H, Yang T, Ghoneim DH, Surendran P, Liu T, Yao Q, Liu T, Fahle S, Butterworth A, Alam MA, Vadgama JV, Deng Y, Deng HW, Wu C, Wu Y, Wu L.   +19 more
europepmc   +4 more sources

Identification of novel plasma proteins as potential therapeutic targets for benign prostatic hyperplasia: a proteome-wide association study. [PDF]

Transl Androl Urol
Benign prostatic hyperplasia (BPH) represents a prevalent age-related disorder with suboptimal pharmacological management. To systematically identify plasma proteins causally linked to BPH pathogenesis and therapeutic potential, we conducted a proteome-wide association study (PWAS) integrated with multi-omics analytical approaches.Genome-wide ...
Luo X, Wu C, Xiong Y, Wang W, Jiang Q, Liu Z.   +5 more
europepmc   +3 more sources

MKRN1 as a prioritized drug target for postpartum depression: evidence from druggable proteome profiling and multi-layer validation [PDF]

Translational Psychiatry
Postpartum depression (PPD) is a significant global health concern affecting women, yet effective and innovative therapeutic targets remain limited.
Tingting Jia, Chengsong Yuan, Shiyi Hu, Liangyue Xie, Andi Liu, Fengqin Qin, Yongji He, Chengcheng Zhang   +7 more
doaj   +2 more sources

Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage

Genome Biology, 2023
AbstractBackgroundThe pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney function and damage.ResultsThrough transcriptome-wide association studies (TWAS) in kidney cortex, kidney ...
Pascal Schlosser, Jingning Zhang, Hongbo Liu, Aditya L. Surapaneni, Eugene P. Rhee, Dan E. Arking, Bing Yu, Eric Boerwinkle, Paul A. Welling, Nilanjan Chatterjee, Katalin Susztak, Josef Coresh, Morgan E. Grams   +12 more
openaire   +3 more sources

Integrative analysis of transcriptome and proteome wide association studies prioritized functional genes for obesity

Human Genetics, 2023
Abstract Background Genome-wide association studies have identified dozens of genomic loci for obesity. However, functional genes and their detailed genetic mechanisms underlying these loci are mainly unknown. In this study, we conducted an integrative study to prioritize plausibly functional genes by combining information from genome ...
Qi-Gang Zhao, Xin-Ling Ma, Qian Xu, Zi-Tong Song, Fan Bu, Kuan Li, Bai-Xue Han, Shan-Shan Yan, Lei Zhang, Yuan Luo, Yu-Fang Pei   +10 more
openaire   +2 more sources

PWAS: Proteome-Wide Association Study [PDF]

, 2019
Abstract Over the last two decades, GWAS (Genome-Wide Association Study) has become a canonical tool for exploratory genetic research, generating countless gene-phenotype associations. Despite its accomplishments, several limitations and drawbacks still hinder its success, including low statistical power and obscurity about the ...
Nadav Brandes, Nathan Linial, Michal Linial   +2 more
openaire   +1 more source

Evaluation of Potential Therapeutic Targets for Bacterial Infectious Skin Diseases: A Proteome-Wide Mendelian Randomization Study [PDF]

Clinical, Cosmetic and Investigational Dermatology
Zhangren Yan,1 Ziyang Shi,2 Ye Wang,2 Hongwei Yin1 1Department of Traditional Chinese Medicine Surgery, Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People’s Republic of China; 2Graduate School, Jiangxi University of Chinese ...
Yan Z, Shi Z, Wang Y, Yin H
doaj   +2 more sources

Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Alzheimer's & Dementia, 2023
AbstractBackgroundLeucine‐rich repeat kinase 2 (LRRK2) common gene variants (tagged by rs76904798) are associated with Parkinson’s disease (PD) risk. In a previous study, we found that rs76904798 was associated with CSF GRN levels, but a comprehensive unbiased analysis of associated proteins remains incomplete due to prior focus on cis‐protein ...
Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga   +26 more
openaire   +5 more sources