Results 21 to 30 of about 41,903,721 (265)

A proteome-wide association study identifies putative causal proteins for breast cancer risk. [PDF]

Br J Cancer
Abstract Background Genome-wide association studies (GWAS) have identified more than 200 breast cancer risk-associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function.
Zhao T, Xu S, Ping J, Jia G, Dou Y, Henry JE, Zhang B, Guo X, Cote ML, Cai Q, Shu XO, Zheng W, Long J.   +12 more
europepmc   +4 more sources

Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer's disease.

PLOS Genetics
Genome-wide association studies (GWAS) performed on large cohort and biobank datasets have identified many genetic loci associated with Alzheimer's disease (AD). However, the younger demographic of biobank participants relative to the typical age of late-
Jingchen Ren, Ruoyu He, Wei Pan, Mykhaylo M Malakhov   +3 more
core   +4 more sources

Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood

Journal of Translational Medicine, 2022
Background Genome-wide association studies (GWAS) have revealed numerous loci associated with stroke. However, the underlying mechanisms at these loci in the pathogenesis of stroke and effective stroke drug targets are elusive.
Bang-Sheng Wu, Shu-Fen Chen, Shu-Yi Huang, Ya-Nan Ou, Yue-Ting Deng, Shi-Dong Chen, Qiang Dong, Jin-Tai Yu   +7 more
doaj   +1 more source

Identifying causal genes for migraine by integrating the proteome and transcriptome

The Journal of Headache and Pain, 2023
Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these variants contribute to the development of migraine.
Shuang-jie Li, Jing-jing Shi, Cheng-yuan Mao, Chan Zhang, Ya-fang Xu, Yu Fan, Zheng-wei Hu, Wen-kai Yu, Xiao-yan Hao, Meng-jie Li, Jia-di Li, Dong-rui Ma, Meng-nan Guo, Chun-yan Zuo, Yuan-yuan Liang, Yu-ming Xu, Jun Wu, Shi-lei Sun, Yong-gang Wang, Chang-he Shi   +19 more
doaj   +1 more source

Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage

Genome Biology, 2023
AbstractBackgroundThe pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney function and damage.ResultsThrough transcriptome-wide association studies (TWAS) in kidney cortex, kidney ...
Pascal Schlosser, Jingning Zhang, Hongbo Liu, Aditya L. Surapaneni, Eugene P. Rhee, Dan E. Arking, Bing Yu, Eric Boerwinkle, Paul A. Welling, Nilanjan Chatterjee, Katalin Susztak, Josef Coresh, Morgan E. Grams   +12 more
openaire   +3 more sources

Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies [PDF]

, 2022
Improved understanding of genetic regulation of proteome can facilitate the identification of causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from 7,213 European American (EA) and 1,871 African American (AA) individuals ...
Grams, Morgan E., Yu, Bing, Coresh, Josef, Zhang, Jingning, Tin, Adrienne, Schlosser, Pascal, Dutta, Diptavo, Boerwinkle, Eric, Chatterjee, Nilanjan, Grams, Morgan E, Harvey, Benjamin, Köttgen, Anna, CKDGen Consortium, Morgan E. Grams, Eric Boerwinkle, Jingning Zhang, Anna Köttgen, Pascal Schlosser, Benjamin Harvey, Diptavo Dutta, Josef Coresh, null null, Nilanjan Chatterjee, Bing Yu, Adrienne Tin   +24 more
core   +1 more source

Integrative analysis of transcriptome and proteome wide association studies prioritized functional genes for obesity

Human Genetics, 2023
Abstract Background Genome-wide association studies have identified dozens of genomic loci for obesity. However, functional genes and their detailed genetic mechanisms underlying these loci are mainly unknown. In this study, we conducted an integrative study to prioritize plausibly functional genes by combining information from genome ...
Qi-Gang Zhao, Xin-Ling Ma, Qian Xu, Zi-Tong Song, Fan Bu, Kuan Li, Bai-Xue Han, Shan-Shan Yan, Lei Zhang, Yuan Luo, Yu-Fang Pei   +10 more
openaire   +2 more sources

PWAS: Proteome-Wide Association Study [PDF]

, 2019
Abstract Over the last two decades, GWAS (Genome-Wide Association Study) has become a canonical tool for exploratory genetic research, generating countless gene-phenotype associations. Despite its accomplishments, several limitations and drawbacks still hinder its success, including low statistical power and obscurity about the ...
Nadav Brandes, Nathan Linial, Michal Linial   +2 more
openaire   +2 more sources

Proteome-Wide Deconvolution of Drug Targets and Binding Sites by Lysine Reactivity Profiling

, 2022
Recently, numerous efforts have been devoted to identifying drug targets and binding sites in complex proteomes, which is of great importance in modern drug discovery.
Mingliang Ye, Mingliang Ye (19659), Chengfei Ruan (8136330), Jiahua Zhou (2617603), Jiahua Zhou, Zheng Fang, Chengfei Ruan, Kejia Li, Xiaolei Zhang, Kejia Li (6262511), Zheng Fang (727034), Xiaolei Zhang (316541), Zhouxian Li (10270108), Zhouxian Li   +13 more
core   +3 more sources

A genome-wide association study identifies protein quantitative trait loci (pQTLs) [PDF]

, 2008
There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and ...
Marjo-Riitta Jarvelin, Simon-Sanchez, J, Hana Lango, Henley W, Greg Tranah, HURST A., Singleton, A, Murray, A, WEEDON M., McCarthy, Mark I, Rafferty I, Lango H, David Melzer, Rafferty, Ian, Singleton A, Bandinelli, S, Bennett, A, BRITTON A., Hurst, A, Newman, Anne B, van de Leemput J, Colin Dayan, GIBBS J., Paolisso, G, Lango, H, Dayan, Colin; id_orcid, Hurst A, Anne B Newman, Murray, Anna, FRAYLING T., Tranah, G, Panicker, V, Perry, John R. B., SHOLZ S., Frayling, Timothy M., Ferrucci, Luigi, Scholz, Sonja, Corsi AM, RICE N., Simon-Sanchez J, J Raphael Gibbs, Tranah G, Harris, Tamara, Jarvelin, Marjo-Riitta, Ruokonen A, Jarvelin, Marjo Riitta, Melzer, D, Paolisso G, Javier Simon-Sanchez, AREPALLI S., Amanda Bennett, Timothy M Frayling, Murray A, Scholz, S, Hernandez D, Fulvio Lauretani, Hurst, Alison, Singleton, Andrew, RAFIQ S., Jarvelin MR, Rafiq S, McCarthy, MI, Rafiq, S, Arepalli, S, van de Leemput, Joyce, PANICKER V., TRANAH G., Guralnik, J, Stevens K, Melzer, David, Rongling Li, Giuseppe Paolisso, Gibbs, J. Raphael, STEVENS K., Sajjad Rafiq, Corsi, Anna Maria, Perry JRB, Bennett A, Harris, T, Perry, John R.B., Bandinelli, Stefania, Nicole Washecka, Lauretani, Fulvio, Lango, Hana, Dena Hernandez, Harris T, Scholz S, McCarthy, Mark I., Frayling, Timothy M, William Henley, HARRIS T., Guralnik J, Stevens, K, Panicker, Vijay, Jack Guralnik, Li, R, DAYAN C., McCarthy MI, Rice N, Weedon, Michael N., Sampath Arepalli, Dayan C, Guralnik, Jack, Lauretani, F, John R B Perry, Melzer D, Dayan, C, Newman, Anne B., Lauretani F, RAFFERTY I., Britton A, Newman AB, Sonja Scholz, Angela Britton, HERNANDEZ D., Frayling TM, Corsi, Anna-Maria, Britton, A, Washecka, Nicole, Andrew Singleton, Ferrucci, L, Tamara Harris, LANGO H., Gibbs, JR, BENNET A., Perry, JRB, Dayan, Colin Mark, Michael N Weedon, Weedon, Michael N, Luigi Ferrucci, Bennett, Amanda, Neil Rice, Rice, N, Anna-Maria Corsi, BANDINELLI S., Washecka, N, Henley, William, Ruokonen, Aimo, Henley, W, Gibbs JR, SIMON SANCHEZ J., Kara Stevens, Arepalli, Sampath, Stevens, Kara, Joyce van de Leemput, MELZER D., Weedon MN, Frayling, TM, Panicker V, SINGLETON A., Weedon, MN, Dayan, Colin, Jarvelin, MR, Anna Murray, Arepalli S, Ferrucci L, FERRUCCI L., Rice, Neil, Li, Rongling, Tranah, Greg, Washecka N, HENLEY W., MCCARTHY M., Perry, John RB, Ruokonen, A, JARVELIN M., Li RL, VAN DE LEEMPUT J., Rafiq, Sajjad, PERRY J., Hernandez, Dena, WASHECKA N., Mark I McCarthy, Vijay Panicker, Ian Rafferty, MURRAY A., LI R., Newman, AB, Bandinelli S, NEWMAN A., Gibbs, J Raphael, Paolisso, Giuseppe, GURALNIK J., Hernandez, D, CORSI A., Van De Leemput, J, Simon-Sanchez, Javier, Stefania Bandinelli, Alison Hurst, RUOKONEN A., Corsi, AM, Britton, Angela, Rafferty, I, Aimo Ruokonen, et al,   +194 more
core   +1 more source