Results 21 to 30 of about 372 (205)

Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Alzheimer's & Dementia, 2023
AbstractBackgroundLeucine‐rich repeat kinase 2 (LRRK2) common gene variants (tagged by rs76904798) are associated with Parkinson’s disease (PD) risk. In a previous study, we found that rs76904798 was associated with CSF GRN levels, but a comprehensive unbiased analysis of associated proteins remains incomplete due to prior focus on cis‐protein ...
Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga   +26 more
openaire   +5 more sources

A Proteome-Wide Association Study Identified Candidate Human Brain Proteins Associated with Coffee Consumption

, 2021
Abstract Background Increasing evidence suggests the association between caffeine and the brain and nervous system. However, there is limited research on the genetic associations between coffee consumption subtypes and brain proteome, plasma proteomes, and peripheral metabolites. Methods First, proteome-wide association study (PWAS) of coffee
Chun'e Li, Xiao Liang, Yumeng Jia, Yan Wen, Huijie Zhang, Shiqiang Cheng, Chuyu Pan, Jingxi Zhang, Zhen Zhang, Yujing Chen, Xuena Yang, Peilin Meng, Yao Yao, Feng Zhang, Cuiyan Wu, Sen Wang, Yujie Ning, Xi Wang   +17 more
openaire   +1 more source

Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence

Journal of Addiction Medicine, 2022
Objectives Alcohol dependence accounts for a large proportion of the global burden of disease and disability. This study aims to investigate the candidate genes and chemicals associated with alcohol dependence. Methods Using data from published alcohol dependence genome-wide ...
Zhang, Jingxi, Meng, Peilin, Yao, Yao, Zhang, Huijie, Pan, Chuyu, Li, Chun'e, Chen, Yujing, Zhang, Zhen, Cheng, Shiqiang, Liu, Li, Yang, Xuena, Jia, Yumeng, Zhang, Feng   +12 more
openaire   +2 more sources

Recessive effects in cancer predisposition exposed by genome-wide and proteome-wide association studies [PDF]

, 2020
Abstract The characterization of germline genetic variation affecting cancer risk, known as cancer predisposition, is fundamental to preventive and personalized medicine. Current attempts to detect cancer predisposition genomic regions are typically based on small-scale familial studies or genome-wide association studies (GWAS) over ...
Nadav Brandes, Nathan Linial, Michal Linial   +2 more
openaire   +1 more source

Proteome-wide association study identifies novel Alzheimer's disease- associated proteins

Journal of Alzheimer’s Disease
Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disease, with a critical shortage of effective prevention and treatment options. Here, we aimed to identify proteins whose genetically regulated plasma levels were associated with AD and its related phenotypes.
Lingyun Sun, Guikang Wei, Feiyang Ji, Yihong Ding, Jiayao Fan, Yue Xu, Chunfeng He, Yuan Zhou, Zuyun Liu, Zeyu Sun, Dan Zhou   +10 more
openaire   +2 more sources

Integrated analysis of proteome-wide and transcriptome-wide association studies identified novel genes and chemicals for vertigo

Brain Communications, 2022
Abstract Vertigo is a leading symptom of various peripheral and central vestibular disorders. Although genome-wide association studies (GWASs) have identified multiple risk variants for vertigo, how these risk variants contribute to the risk of vertigo remains unknown.
Bolun Cheng, Peilin Meng, Xuena Yang, Shiqiang Cheng, Li Liu, Yumeng Jia, Yan Wen, Feng Zhang   +7 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age

Nature Communications, 2019
Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated with
Aliza P. Wingo, Eric B. Dammer, Michael S. Breen, Benjamin A. Logsdon, Duc M. Duong, Juan C. Troncosco, Madhav Thambisetty, Thomas G. Beach, Geidy E. Serrano, Eric M. Reiman, Richard J. Caselli, James J. Lah, Nicholas T. Seyfried, Allan I. Levey, Thomas S. Wingo   +14 more
doaj   +1 more source