Results 1 to 10 of about 44,050 (232)

Brain proteome‐wide association study linking‐genes in multiple sclerosis pathogenesis [PDF]

Annals of Clinical and Translational Neurology, 2023
Objectives To identify genes that confer MS risk via the alteration of cis‐regulated protein abundance and verify their aberrant expression in human brain.
Tingting Jia, Yanni Ma, Fengqin Qin, Feng Han, Chengcheng Zhang   +4 more
doaj   +4 more sources

PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins [PDF]

Genome Biology, 2020
We introduce Proteome-Wide Association Study (PWAS), a new method for detecting gene-phenotype associations mediated by protein function alterations. PWAS aggregates the signal of all variants jointly affecting a protein-coding gene and assesses their ...
Nadav Brandes, Nathan Linial, Michal Linial   +2 more
doaj   +5 more sources

Identification of novel functional brain proteins for treatment-resistant schizophrenia: Based on a proteome-wide association study [PDF]

European Psychiatry, 2023
Objective Genetic approaches are increasingly advantageous in characterizing treatment-resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain proteins, providing a potential pathway for improving psychiatric classification ...
Wenming Wei, Huijie Zhang, Bolun Cheng, Xiaoyue Qin, Dan He, Na Zhang, Yijing Zhao, Qingqing Cai, Sirong Shi, Xiaoge Chu, Yan Wen, Huan Liu, Yumeng Jia, Feng Zhang   +13 more
doaj   +4 more sources

Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood

Journal of Translational Medicine, 2022
Background Genome-wide association studies (GWAS) have revealed numerous loci associated with stroke. However, the underlying mechanisms at these loci in the pathogenesis of stroke and effective stroke drug targets are elusive.
Bang-Sheng Wu, Shu-Fen Chen, Shu-Yi Huang, Ya-Nan Ou, Yue-Ting Deng, Shi-Dong Chen, Qiang Dong, Jin-Tai Yu   +7 more
doaj   +1 more source

Identifying causal genes for migraine by integrating the proteome and transcriptome

The Journal of Headache and Pain, 2023
Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these variants contribute to the development of migraine.
Shuang-jie Li, Jing-jing Shi, Cheng-yuan Mao, Chan Zhang, Ya-fang Xu, Yu Fan, Zheng-wei Hu, Wen-kai Yu, Xiao-yan Hao, Meng-jie Li, Jia-di Li, Dong-rui Ma, Meng-nan Guo, Chun-yan Zuo, Yuan-yuan Liang, Yu-ming Xu, Jun Wu, Shi-lei Sun, Yong-gang Wang, Chang-he Shi   +19 more
doaj   +1 more source

Identification and validation of novel risk genes for intervertebral disc disorder by integrating large-scale multi-omics analyses and experimental studies

Frontiers in Medicine
IntroductionAlthough genome-wide association studies (GWAS) have identified multiple genetic loci linked to intervertebral disc disorder (IDD), their functional characterization remains largely unelucidated.
Zhe Zhang, Zhe Zhang, Yu Chen, Qianjin Wang, Zheng Li, Bingyang Dai, Bingyang Dai, Cheng Dong, Cheng Dong, Zhengya Zhu   +9 more
doaj   +1 more source

A genetic correlation scan identifies blood proteins associated with bone mineral density

BMC Musculoskeletal Disorders, 2022
Background Osteoporosis is a common metabolic bone disease that is characterized by low bone mass. However, limited efforts have been made to explore the functional relevance of the blood proteome to bone mineral density across different life stages ...
Jiawen Xu, Shaoyun Zhang, Haibo Si, Yi Zeng, Yuangang Wu, Yuan Liu, Mingyang Li, Limin Wu, Bin Shen   +8 more
doaj   +1 more source

Elucidating the susceptibility to breast cancer: an in-depth proteomic and transcriptomic investigation into novel potential plasma protein biomarkers

Frontiers in Molecular Biosciences
Objectives: This study aimed to identify plasma proteins that are associated with and causative of breast cancer through Proteome and Transcriptome-wide association studies combining Mendelian Randomization.Methods: Utilizing high-throughput datasets, we
Yang Wang, Kexin Yi, Baoyue Chen, Bailin Zhang, Gao Jidong, Gao Jidong   +5 more
doaj   +1 more source

Identifying novel potential drug targets for endometriosis via plasma proteome screening

Frontiers in Endocrinology
BackgroundEndometriosis (EM) is a chronic painful condition that predominantly affects women of reproductive age. Currently, surgery or medication can only provide limited symptom relief.
Tian Tao, Xiaoyu Mo, Liangbin Zhao
doaj   +1 more source

Identification of Candidate Lung Function-Related Plasma Proteins to Pinpoint Drug Targets for Common Pulmonary Diseases: A Comprehensive Multi-Omics Integration Analysis

Current Issues in Molecular Biology
The genome-wide association studies (GWAS) of lung disease and lung function indices suffer from challenges to be transformed into clinical interventions, due to a lack of knowledge on the molecular mechanism underlying the GWAS associations.
Yansong Zhao, Lujia Shen, Ran Yan, Lu Liu, Ping Guo, Shuai Liu, Yingxuan Chen, Zhongshang Yuan, Weiming Gong, Jiadong Ji   +9 more
doaj   +1 more source