Results 11 to 20 of about 44,050 (232)

Proteome-wide association study of prostate cancer risk across populations [PDF]

Nature Communications
There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be ...
Hua Zhong, Jingjing Zhu, Shuai Liu, Chong Wu, Liang Wang, Seamus P. Whelton, Catherine H. Marshall, Michael J. Blaha, Peter Durda, Xiuqing Guo, Craig W. Johnson, Henry J. Lin, Kent D. Taylor, Russell P. Tracy, Ronit I. Yarden, Ani W. Manichaikul, Stephen S. Rich, Jerome I. Rotter, Rajat Deo, Ruth F. Dubin, Peter Ganz, Lang Wu   +21 more
doaj   +5 more sources

New insights into the hypothalamic–pituitary– thyroid axis: a transcriptome- and proteome-wide association study [PDF]

European Thyroid Journal
Introduction: Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues.
Sara Monteiro-Martins, Rosalie B T M Sterenborg, Oleg Borisov, Nora Scherer, Yurong Cheng, Marco Medici, Anna Köttgen, Alexander Teumer   +7 more
doaj   +8 more sources

Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases [PDF]

Cardiovascular Diabetology
Background Cardiovascular diseases (CVD) are the leading cause of global mortality, yet current treatments benefit only a subset of patients. To identify new potential treatment targets, we conducted the first proteome wide association study (PWAS) for ...
Jia-Hao Wang, Shan-Shan Dong, Wei Huang, Hao-An Wang, Shao-Shan Liu, Xiaoyi Ma, Ren-Jie Zhu, Wei Shi, Hao Wu, Ke Yu, Tian-Pei Zhang, Cong-Ru Wang, Yan Guo, Hanzhong Xue, Tie-Lin Yang   +14 more
doaj   +4 more sources

Novel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study [PDF]

Scientific Reports
Atopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current
Chen Luo, YaJing Zhang, QiFan Feng, KaiXin Yao, LeiLei Zheng, Ye Yang, WenXin Zheng, Feng Li, YongQiang Lv, Yue Cai   +9 more
doaj   +4 more sources

Brain proteome-wide association study implicates novel proteins in depression pathogenesis. [PDF]

Nat Neurosci, 2021
Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N = 376) to perform a proteome-wide association study of depression followed by Mendelian randomization.
Wingo TS, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, Dammer EB, Lori A, Kim PJ, Ressler KJ, Beach TG, Reiman EM, Epstein MP, De Jager PL, Lah JJ, Bennett DA, Seyfried NT, Levey AI, Wingo AP.   +18 more
europepmc   +6 more sources

Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease. [PDF]

Am J Hum Genet
Alzheimer disease (AD) is a complex and progressive neurodegenerative disorder that accounts for the majority of individuals with dementia. Here, we aim to identify causal plasma proteins for AD, shedding light on the etiology of AD. We utilized the latest large-scale plasma proteomic data from the UK Biobank Pharma Proteomics Project (UKB-PPP) and AD ...
Fang L, Xue H, Lin Z, Pan W.
europepmc   +3 more sources

Proteome-Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease. [PDF]

CNS Neurosci Ther
ABSTRACT Objective To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset and progression of Parkinson's disease (PD) through integrative proteomic and genetic analyses ...
Gao C, Zhou H, Liang W, Wen Z, Liao W, Xie Z, Liao C, He L, Sun J, Chen Z, Li D, Yuan N, Huang C, Zhang J.   +13 more
europepmc   +3 more sources

A proteome-wide association study identifies putative causal proteins for breast cancer risk. [PDF]

Br J Cancer
Abstract Background Genome-wide association studies (GWAS) have identified more than 200 breast cancer risk-associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function.
Zhao T, Xu S, Ping J, Jia G, Dou Y, Henry JE, Zhang B, Guo X, Cote ML, Cai Q, Shu XO, Zheng W, Long J.   +12 more
europepmc   +4 more sources

A proteome-wide association study reveals novel plasma proteins as potential therapeutic targets for metabolic dysfunction-associated steatotic liver disease [PDF]

Frontiers in Endocrinology
IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health burden with limited therapeutic options. To identify novel proteins involved in its pathogenesis and reveal potential drug targets, we performed an ...
Qian Zhong, Yue Zhu, Yiwen Tan, Wenzeng Deng, Chunxia Wang, Shan Yang, Nanwei Tong, Nanwei Tong   +7 more
doaj   +2 more sources

Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster [PDF]

Nature Communications, 2016
How genetic diversity generates complex phenotypes along a continuum remains a fundamental question of biology. Here—applying the emerging SWATH proteomics technology—the authors describe a proteome wide association study (PWAS) of Drosophila wing size ...
Hirokazu Okada, H. Alexander Ebhardt, Sibylle Chantal Vonesch, Ruedi Aebersold, Ernst Hafen   +4 more
doaj   +7 more sources