Results 11 to 20 of about 372 (205)
Proteome-wide association study of prostate cancer risk across populations
Nature CommunicationsThere is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be ...
Hua Zhong +21 more
doaj +4 more sources
Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster [PDF]
Nature Communications, 2016 How genetic diversity generates complex phenotypes along a continuum remains a fundamental question of biology. Here—applying the emerging SWATH proteomics technology—the authors describe a proteome wide association study (PWAS) of Drosophila wing size ...
Hirokazu Okada +4 more
doaj +7 more sources
Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies [PDF]
HGG Advances, 2023 Summary: Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most ...
Daiwei Zhang +21 more
doaj +5 more sources
New insights into the hypothalamic–pituitary– thyroid axis: a transcriptome- and proteome-wide association study [PDF]
European Thyroid JournalIntroduction: Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues.
Sara Monteiro-Martins +7 more
doaj +6 more sources
Cardiovascular DiabetologyBackground Cardiovascular diseases (CVD) are the leading cause of global mortality, yet current treatments benefit only a subset of patients. To identify new potential treatment targets, we conducted the first proteome wide association study (PWAS) for ...
Jia-Hao Wang +14 more
doaj +3 more sources
Scientific ReportsAtopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current
Chen Luo +9 more
doaj +3 more sources
Brain proteome-wide association study implicates novel proteins in depression pathogenesis
Nature Neuroscience, 2021 Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N = 376) to perform a proteome-wide association study of depression followed by Mendelian randomization.
Thomas S. Wingo +18 more
openaire +5 more sources
Genome Biology, 2023 AbstractBackgroundThe pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney function and damage.ResultsThrough transcriptome-wide association studies (TWAS) in kidney cortex, kidney ...
Pascal Schlosser +12 more
openaire +3 more sources
Human Genetics, 2023 Abstract Background Genome-wide association studies have identified dozens of genomic loci for obesity. However, functional genes and their detailed genetic mechanisms underlying these loci are mainly unknown. In this study, we conducted an integrative study to prioritize plausibly functional genes by combining information from genome ...
Qi-Gang Zhao +10 more
openaire +2 more sources
PWAS: Proteome-Wide Association Study [PDF]
, 2019 Abstract Over the last two decades, GWAS (Genome-Wide Association Study) has become a canonical tool for exploratory genetic research, generating countless gene-phenotype associations. Despite its accomplishments, several limitations and drawbacks still hinder its success, including low statistical power and obscurity about the ...
Nadav Brandes +2 more
openaire +2 more sources