Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster [PDF]
Nature Communications, 2016 How genetic diversity generates complex phenotypes along a continuum remains a fundamental question of biology. Here—applying the emerging SWATH proteomics technology—the authors describe a proteome wide association study (PWAS) of Drosophila wing size ...
Hirokazu Okada +4 more
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Brain proteome-wide association study implicates novel proteins in depression pathogenesis. [PDF]
Nat Neurosci, 2021 Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N = 376) to perform a proteome-wide association study of depression followed by Mendelian randomization.
Wingo TS +18 more
europepmc +8 more sources
ICA1L Is Associated with Small Vessel Disease: A Proteome-Wide Association Study in Small Vessel Stroke and Intracerebral Haemorrhage. [PDF]
Int J Mol Sci, 2022 Small vessel strokes (SVS) and intracerebral haemorrhages (ICH) are acute outcomes of cerebral small vessel disease (SVD). Genetic studies combining both phenotypes have identified three loci associated with both traits. However, the genetic cis-regulation at the protein level associated with SVD has not been studied before.
Cullell N +11 more
europepmc +8 more sources
Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder. [PDF]
Genes (Basel), 2022 Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer risk of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with the PTSD GWAS dataset, respectively, to conduct a ...
Zhang Z +13 more
europepmc +5 more sources
The genetic structure of pain in depression patients: A genome-wide association study and proteome-wide association study [PDF]
Journal of Psychiatric Research, 2022 Comparing with the general population, the pain in depression patients has more complex biological mechanism. We aim to explore the etiological mechanism of pain in depression patients from the perspective of genetics.Utilizing the UK Biobank samples with self-reported depression status or PHQ score ≥10, we conducted genome-wide association studies ...
Zhen Zhang +13 more
exaly +5 more sources
Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia. [PDF]
Am J Hum GenetTranscriptome-wide association study (TWAS) tools have been applied to conduct proteome-wide association studies (PWASs) by integrating proteomics data with genome-wide association study (GWAS) summary data. The genetic effects of PWAS-identified significant genes are potentially mediated through genetically regulated protein abundance, thus informing ...
Hu T +8 more
europepmc +5 more sources
Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies [PDF]
HGG Advances, 2023 Summary: Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most ...
Daiwei Zhang +21 more
doaj +5 more sources
Genome Biology, 2023 Background The pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney function and ...
Pascal Schlosser +12 more
doaj +3 more sources
Evaluation of Potential Therapeutic Targets for Bacterial Infectious Skin Diseases: A Proteome-Wide Mendelian Randomization Study [PDF]
Clinical, Cosmetic and Investigational DermatologyZhangren Yan,1 Ziyang Shi,2 Ye Wang,2 Hongwei Yin1 1Department of Traditional Chinese Medicine Surgery, Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People’s Republic of China; 2Graduate School, Jiangxi University of Chinese ...
Yan Z, Shi Z, Wang Y, Yin H
doaj +2 more sources
Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease. [PDF]
Am J Hum GenetAlzheimer disease (AD) is a complex and progressive neurodegenerative disorder that accounts for the majority of individuals with dementia. Here, we aim to identify causal plasma proteins for AD, shedding light on the etiology of AD. We utilized the latest large-scale plasma proteomic data from the UK Biobank Pharma Proteomics Project (UKB-PPP) and AD ...
Fang L, Xue H, Lin Z, Pan W.
europepmc +3 more sources