Results 11 to 20 of about 41,903,721 (265)

ICA1L Is Associated With Small Vessel Disease: A Proteome-Wide Association Study in Small Vessel Stroke and Intracerebral Haemorrhage [PDF]

International Journal of Molecular Sciences, 2022
Small vessel strokes (SVS) and intracerebral haemorrhages (ICH) are acute outcomes of cerebral small vessel disease (SVD). Genetic studies combining both phenotypes have identified three loci associated with both traits.
Natalia Cullell, Elena Muino, Miquel Lledós   +2 more
exaly   +12 more sources

Brain Proteome-Wide Association Study Identifies Candidate Genes That Regulate Protein Abundance Associated With Post-Traumatic Stress Disorder [PDF]

Genes, 2022
Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer risk of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome
Zhen Zhang
exaly   +5 more sources

Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies [PDF]

HGG Advances, 2023
Summary: Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most ...
Daiwei Zhang, Boran Gao, Qidi Feng, Ani Manichaikul, Gina M. Peloso, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Stacey Gabriel, Namrata Gupta, Joshua D. Smith, Francois Aguet, Kristin G. Ardlie, Thomas W. Blackwell, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Laura J. Scott, Xiang Zhou, Seunggeun Lee   +21 more
doaj   +7 more sources

Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster [PDF]

Nature Communications, 2016
How genetic diversity generates complex phenotypes along a continuum remains a fundamental question of biology. Here—applying the emerging SWATH proteomics technology—the authors describe a proteome wide association study (PWAS) of Drosophila wing size ...
Hirokazu Okada, H. Alexander Ebhardt, Sibylle Chantal Vonesch, Ruedi Aebersold, Ernst Hafen   +4 more
doaj   +9 more sources

Brain proteome-wide association study implicates novel proteins in depression pathogenesis. [PDF]

Nat Neurosci, 2021
Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N = 
Wingo TS, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, Dammer EB, Lori A, Kim PJ, Ressler KJ, Beach TG, Reiman EM, Epstein MP, De Jager PL, Lah JJ, Bennett DA, Seyfried NT, Levey AI, Wingo AP.   +18 more
europepmc   +7 more sources

Omnibus Proteome-Wide Association Study Identifies 43 Risk Genes for Alzheimer Disease Dementia [PDF]

American Journal of Human Genetics
Transcriptome-wide association study (TWAS) tools have been applied to conduct proteome-wide association studies (PWASs) by integrating proteomics data with genome-wide association study (GWAS) summary data. The genetic effects of PWAS-identified significant genes are potentially mediated through genetically regulated protein abundance, thus informing ...
Michael P Epstein, Jingjing Yang, Nicholas T Seyfried   +2 more
exaly   +4 more sources

Proteome-Wide Structural Probing of Low-Abundant Protein Interactions by Cross-Linking Mass Spectrometry

, 2020
Proteome-wide cross-linking studies have spurred great interest as they facilitate structural probing of protein interactions in living cells and organisms. However, current studies have a bias for high-abundant proteins.
Stefan G. Kreft (8462427), Julius Fürsch (8462421), Kai-Michael Kammer (8462424), Martin Beck (844357), Florian Stengel (428563)   +4 more
core   +6 more sources

DNAJB12 mediates the causal effect of obesity on knee osteoarthritis: A mendelian randomization study [PDF]

Osteoarthritis and Cartilage Open
Objective: Obesity is a major risk factor for knee osteoarthritis (KOA), but the circulating proteins that mediate this association remain unclear. We aimed to identify obesity-regulated circulating proteins that causally influence KOA risk.
An Wang, Hongying Shan, Xi Cao, Ye Li, Xuzhao Bian, Di Zhang, Xingjie Hao, Shiquan Sun   +7 more
doaj   +2 more sources

Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease. [PDF]

Am J Hum Genet
Alzheimer disease (AD) is a complex and progressive neurodegenerative disorder that accounts for the majority of individuals with dementia. Here, we aim to identify causal plasma proteins for AD, shedding light on the etiology of AD. We utilized the latest large-scale plasma proteomic data from the UK Biobank Pharma Proteomics Project (UKB-PPP) and AD ...
Fang L, Xue H, Lin Z, Pan W.
europepmc   +3 more sources

Proteome-Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease. [PDF]

CNS Neurosci Ther
ABSTRACT Objective To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset and progression of Parkinson's disease (PD) through integrative proteomic and genetic analyses ...
Gao C, Zhou H, Liang W, Wen Z, Liao W, Xie Z, Liao C, He L, Sun J, Chen Z, Li D, Yuan N, Huang C, Zhang J.   +13 more
europepmc   +3 more sources