Results 51 to 60 of about 114,169 (274)

Acute kidney injury prediction in cardiac surgery patients by a urinary peptide pattern: a case-control validation study [PDF]

, 2016
Background Acute kidney injury (AKI) is a prominent problem in hospitalized patients and associated with increased morbidity and mortality. Clinical medicine is currently hampered by the lack of accurate and early biomarkers for diagnosis of AKI and the
Groesdonk, Heiner, Herget-Rosenthal, Stefan, Husi, Holger, Klingele, Matthias, Metzger, Jochen, Mischak, Harald, Mullen, William, Stalmach, Angelique   +7 more
core   +3 more sources

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]

, 2020
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar, Grieben, Ulrike, Grunwald, Stefanie Anke, Haafke, Stefanie, Jedraszczak, Nicole, Kress, Wolfram, Patone, Giannino, Popp, Oliver, Saar, Kathrin, Spuler, Simone, Steinhagen-Thiessen, Elisabeth   +10 more
core   +1 more source

Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence

Journal of Addiction Medicine, 2022
Objectives Alcohol dependence accounts for a large proportion of the global burden of disease and disability. This study aims to investigate the candidate genes and chemicals associated with alcohol dependence. Methods Using data from published alcohol dependence genome-wide ...
Zhang, Jingxi, Meng, Peilin, Yao, Yao, Zhang, Huijie, Pan, Chuyu, Li, Chun'e, Chen, Yujing, Zhang, Zhen, Cheng, Shiqiang, Liu, Li, Yang, Xuena, Jia, Yumeng, Zhang, Feng   +12 more
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Identifying novel potential drug targets for endometriosis via plasma proteome screening

Frontiers in Endocrinology
BackgroundEndometriosis (EM) is a chronic painful condition that predominantly affects women of reproductive age. Currently, surgery or medication can only provide limited symptom relief.
Tian Tao, Xiaoyu Mo, Liangbin Zhao
doaj   +1 more source

Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression [PDF]

, 2012
Our understanding of the mechanisms by which nonalcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH) is still very limited.
Alonso, C, Barr, J, Caballería, J, Domínguez-Díez, A, Martínez Arranz, Ibon, Moto, J.M., Muntané Relat, Jordi, Romero Gómez, Manuel   +7 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Identification of Candidate Lung Function-Related Plasma Proteins to Pinpoint Drug Targets for Common Pulmonary Diseases: A Comprehensive Multi-Omics Integration Analysis

Current Issues in Molecular Biology
The genome-wide association studies (GWAS) of lung disease and lung function indices suffer from challenges to be transformed into clinical interventions, due to a lack of knowledge on the molecular mechanism underlying the GWAS associations.
Yansong Zhao, Lujia Shen, Ran Yan, Lu Liu, Ping Guo, Shuai Liu, Yingxuan Chen, Zhongshang Yuan, Weiming Gong, Jiadong Ji   +9 more
doaj   +1 more source

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age

Nature Communications, 2019
Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated with
Aliza P. Wingo, Eric B. Dammer, Michael S. Breen, Benjamin A. Logsdon, Duc M. Duong, Juan C. Troncosco, Madhav Thambisetty, Thomas G. Beach, Geidy E. Serrano, Eric M. Reiman, Richard J. Caselli, James J. Lah, Nicholas T. Seyfried, Allan I. Levey, Thomas S. Wingo   +14 more
doaj   +1 more source

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources