Results 71 to 80 of about 41,903,721 (265)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Association between air pollution exposure and increased chronic kidney disease risk: the modifying effects of genetic susceptibility, transcriptomic, and proteomic signatures

BMC Medicine
Background Air pollution exposure is increasingly recognized as a risk factor for chronic kidney disease (CKD), but the underlying mechanisms, especially the complex gene-environment interactions as reflected in genetic susceptibility, transcriptomic ...
Jian Lu, Shuaigang Sun, Xinru Shang, Zekai Deng, Shunwei Wang, Shimin Jiang, Wenge Li   +6 more
doaj   +1 more source

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration [PDF]

, 2011
To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-
Richard W. Morris, Kumari, Meena, Hardy, R, Berry, Diane J, Cooper, Jackie, Ulf de Faire, Angelakopoulou, A, Jutta Palmen, de Faire, Ulf, Tzoulaki, I, Fowkes, F. Gerry R., Marmot, Michael, Samani, Nilesh, Price, Jackie; id_orcid, Andrew Wong, Wong, A, Munroe, Patricia B, Kumari, M, Shah, T, Jefferis, BJ, Deanfield, John, Simpson, Iain A., Simpson, Iain A, Shah, S, Juan P. Casas, Thomson, Andy, Jefferis, Barbara J., Samani, N, Whittaker, John C, Bruna Gigante, Philippa J. Talmud, Lathrop, Mark, Munroe, Patricia B., John C. Whittaker, Drenos, F, Motterle, Anna, John Deanfield, F. Gerry R. Fowkes, Helen Ireland, Shu Ye, Price, J, Whincup, PH, Steve E. Humphries, Verzilli, C, Kivimaki, Mika, Power, C, Leander, Karin, Sofat, R, Jackie Price, Hypponen, Elina, Caulfield, Mark, Humphries, Steve E, Tina Shah, Anna Motterle, Kuh, Diana, Jefferis, Barbara J, Gigante, B, Maniatis, Nikolas, Whincup, Peter H, Casas, Juan P, Palmen, J, Diana Kuh, Shah, Sonia, Liam Smeeth, Gigante, Bruna, Ireland, Helen, Price, Jackie, Thomson, A, Elina Hypponen, Verzilli, Claudio, Nikolas Maniatis, Smeeth, Liam, Casas, JP, Angelakopoulou, Aspasia, Marmot, M, Ross C. Laxton, Munroe, PB, Barbara J. Jefferis, Cooper, J, Wallace, C, Simpson, IA, Caulfield, M, Talmud, PJ, Andy Thomson, Laxton, Ross C., Drenos, Fotios, Morris, Richard W, Iain A. Simpson, Chris Wallace, Mika Kivimaki, Lathrop, M, Humphries, SE, Motterle, A, Hingorani, AD, de Faire, U, Whittaker, JC, Meena Kumari, Jackie Cooper, Laxton, Ross C, Ioanna Tzoulaki, Claudio Verzilli, Ye, S, Wallace, Chris, Sonia Shah, Hardy, Rebecca, Shah, Tina, Aspasia Angelakopoulou, Berry, DJ, Hingorani, Aroon D, Laxton, RC, Nilesh Samani, Hypponen, E, Fowkes, F Gerry R, Morris, RW, Diane J. Berry, Rebecca Hardy, Maniatis, N, Mark Lathrop, Fowkes, FG, Reecha Sofat, Tzoulaki, Ioanna, Chris Power, Michael Marmot, Leander, K, Power, Chris, Smeeth, L, Mark Caulfield, Ye, Shu, Sofat, Reecha, Ireland, H, Fotios Drenos, Talmud, Philippa J, Kuh, D, Deanfield, J, Kivimaki, M, Wong, Andrew, Peter H. Whincup, Patricia B. Munroe, Berry, Diane J., Karin Leander, Palmen, Jutta, Aroon D. Hingorani, Hingorani, A.D., Angelakopoulou, A., Hypponen, E., Sofat, R., Shah, S., Shah, T.   +147 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Integrating plasma proteomics with genome-wide association data to identify novel drug targets for inflammatory bowel disease

Scientific Reports
Inflammatory bowel disease (IBD) is a chronic disease that includes Crohn’s disease (CD) and ulcerative colitis (UC). Although genome-wide association studies (GWASs) have identified many relevant genetic risk loci, the impact of these loci on protein ...
Zhongyuan Bai, Jiawei Hao, Miaoran Chen, Kaixin Yao, Leilei Zheng, Liu Liu, Jingxi Hu, Kaiqing Guo, Yongqiang Lv, Feng Li   +9 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Proteomic Mendelian randomization to identify protein biomarkers of telomere length

Scientific Reports
Shortening of telomere length (TL) is correlated with many age-related disorders and is a hallmark of biological aging. This study used proteome-wide Mendelian randomization to identify the protein biomarkers associated with telomere length.
Jiaxuan Zhao, Kun Yang, Yunfei Lu, Linfeng Zhou, Haoran Fu, Jingbo Feng, Jinghua Wu   +6 more
doaj   +1 more source

T Cell Antigen Discovery Using Soluble Vaccinia Proteome Reveals Recognition of Antigens with Both Virion and Nonvirion Association [PDF]

, 2014
Vaccinia virus (VACV) is a useful model system for understanding the immune response to a complex pathogen. Proteome-wide Ab profiling studies reveal the humoral response to be strongly biased toward virion-associated Ags, and several membrane proteins ...
Hermanson, Gary, Liang, Xiaowu, Davies, D Huw, Jain, Aarti, Pablo, Jozelyn, Felgner, Philip L, Tucker, Jo Anne, Chun, Sookhee, Nakajima, Rie   +8 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals

Nature Communications
Understanding the genetic architecture of the circulating proteome can help determine if a protein is causally linked to disease. Previous large-scale genome-wide association studies of proteins have mostly been conducted on pre-defined, targeted subsets
Anne Richmond, Josephine A. Robertson, Hannah M. Smith, Robert F. Hillary, Aleksej Zelezniak, Spyros Vernardis, Aleksandra D. Chybowska, Arturas Grauslys, Jure Mur, Archie Campbell, Camilla Drake, Hannah Grant, Poppy Adkin, Matthew White, Charles Brigden, Christoph B. Messner, David J. Porteous, Caroline Hayward, Andrew M. McIntosh, Daniel L. McCartney, Markus Ralser, Riccardo E. Marioni   +21 more
doaj   +1 more source