Results 81 to 90 of about 372 (205)

An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis

Communications Biology
Psoriatic arthritis (PsA) is a complex, chronic immune-mediated inflammatory arthropathy that currently lacks definitive biomarkers and treatment targets. Identifying biomarkers and treatment targets is urgently needed for effectively managing PsA. Here,
Yi-Xin Cai, Dai-Shan Zheng, Xiao-Li Chen, Zhan-Pei Bai, Jinyi Zhang, Wenhai Deng, Xiu-Feng Huang   +6 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Multi-omic characterization of air pollution effects: Applications of AirSigOmniTWP Hub

Ecotoxicology and Environmental Safety
Air pollution, particularly fine particulate matter and gaseous pollutants including NO2 and NOx, presents significant public health challenges. While the harmful effects of these pollutants are well-documented, the molecular mechanisms underlying their ...
Wei Liu, Tong Liu, Xinxin Si, Jiaxing Liang, Xia Yan, Juexin Zhang, Bing Pang, Wenmin Luo, Junhong Liu, Huazhe Yang, Peng Shi   +10 more
doaj   +1 more source

Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma

GigaScience
Abstract   Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy, largely due to the paucity of reliable biomarkers for early detection and therapeutic targeting. Existing blood protein biomarkers for PDAC often suffer from replicability issues, arising from inherent limitations such as ...
Jingjing Zhu, Ke Wu, Shuai Liu, Alexandra Masca, Hua Zhong, Tai Yang, Dalia H Ghoneim, Praveen Surendran, Tanxin Liu, Qizhi Yao, Tao Liu, Sarah Fahle, Adam Butterworth, Md Ashad Alam, Jaydutt V Vadgama, Youping Deng, Hong-Wen Deng, Chong Wu, Yong Wu, Lang Wu   +19 more
openaire   +2 more sources

Methylome-wide association studies and epigenetic biomarker development for 133 mass spectrometry-assessed circulating proteins in 14,671 Generation Scotland participants

Genome Biology
Background DNA methylation (DNAm) can regulate gene expression, and its genome-wide patterns (epigenetic scores or EpiScores) can act as biomarkers for complex traits. The relative stability of methylation profiles may enable better assessment of chronic
Josephine A. Robertson, Jakub Bajzik, Spyros Vernardis, Aleksandra D. Chybowska, Daniel L. McCartney, Arturas Grauslys, Jure Mur, Hannah M. Smith, Archie Campbell, Camilla Drake, Hannah Grant, Jamie Pearce, Tom C. Russ, Poppy Adkin, Matthew White, Charles Brigden, Christoph B. Messner, David J. Porteous, Caroline Hayward, Simon R. Cox, Aleksej Zelezniak, Markus Ralser, Matthew R. Robinson, Riccardo E. Marioni   +23 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Enhancing nonlinear transcriptome- and proteome-wide association studies via trait imputation with applications to Alzheimer’s disease

PLOS Genetics
Genome-wide association studies (GWAS) performed on large cohort and biobank datasets have identified many genetic loci associated with Alzheimer’s disease (AD). However, the younger demographic of biobank participants relative to the typical age of late-onset AD has resulted in an insufficient number of AD cases, limiting the statistical power of GWAS
Ruoyu He, Jingchen Ren, Mykhaylo M. Malakhov, Wei Pan   +3 more
openaire   +3 more sources

Genetic insights support PARP1 as a mediator in the protective association of ATP-citrate lyase inhibitors with melanoma

Communications Biology
ATP-citrate lyase (ACLY) inhibitors emerge as a promising anti-cancer strategy, yet their causal effects across various cancer types remain unclear.
Jiawen Lu, Gloria Hoi-Yee Li, Jingyi Hu, Zhenqian Wang   +3 more
doaj   +1 more source

Admixture-mapping analysis reveals genetic determinants of the human plasma proteome

HGG Advances
Summary: Protein profiling and genetic findings can be integrated to define the genetic architecture of the circulating proteome in chronic diseases. Most self-identified African American (AA) individuals have both African and European genetic ancestry ...
Daniel E. Cruz, Shuliang Deng, Usman A. Tahir, Zsu-Zsu Chen, Mark D. Benson, Bjoernar Tuftin, Jiawen Chen, Laurie Farrell, Dongxiao Shen, Mariah Meyer, Ethan Lange, Yan Gao, Michael E. Hall, Russell P. Tracy, Stephen S. Rich, Kent Taylor, Ani Manichaikul, Jerome I. Rotter, Tamar Sofer, James G. Wilson, Robert E. Gerszten, Laura M. Raffield   +21 more
doaj   +1 more source