Results 81 to 90 of about 41,903,721 (265)

Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1 [PDF]

, 2011
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age. Affected individuals suffer from uncomfortable sensations and an urge to move in the lower limbs that ...
Juliane Winkelmann, Sona Nevsimalova, Dauvilliers, Yves, Bachmann, Cornelius G., Wichmann, H. -Erich, Knauf F, Wichmann HE, Gschliesser V, Kettunen Johannes, Fontaine, B., Vávrová J, Müller-Myhsok, B., Montplaisir Jacques, Ondo, William, G., Czamara, D., Le Wei-Dong, Bertram Müller-Myhsok, Schulte, E.C., Birgit Högl, Fietze Ingo, Stiasny-Kolster, Karin, Kettunen, Johannes, Kaffe M, Müller Myhsok B, Vodicka, P., H.-Erich Wichmann, Vilariño-Güell, Carles, Wichmann, H.-E., Gschliesser, V., Perola Markus, Xiong, L., Illig Thomas, Silander, K., Fontenille C, Berger K, Bertram Müller-Myhsok, Berger, K., Cournu Rebeix I, Kaffe, Maria, Sonka K, Faraco J, Mueller-Myhsok, Bertram, Maria Kaffe, Sonka, K., Müller-Myhsok Bertram, Earley CJ, Cournu-Rebeix Isabelle, Kemlink David, Stiasny Kolster K, Vilariño-Güell Carles, Poewe Werner, Kaffe Maria, Ondo William G., Lichtner, P., Zimprich A, Fietze, I., Fontaine Bertrand, Bachmann, C.G., Farrer, Matthew J., Olli Polo, Vavrova, J., Hoegl, Birgit, Cournu-Rebeix, I., Oertel Wolfgang, Högl Birgit, Kettunen J, Zimprich, A., Meitinger, T., Fontaine, Bertrand, Högl, B., Richard P. Allen, Faraco, J., William G. Ondo, Lin Siong-Chi, Oertel, Wolfgang, Allen, Richard P., Meitinger T., Fuhs, Andrea, Cornelius G. Bachmann, Wichmann, H-Erich, Wszolek Zbigniew, Perola M, Polo, Olli, Meitinger Thomas, Darina Czamara, Xiong L, Siong-Chi Lin, Allen, R., Knauf, F., Le, Wei-Dong, Gross Nadine, Bachmann, C., Gieger, C., Berger, Klaus, Cournu-Rebeix, Isabelle, Matthew J Farrer, Paulus Walter, Peppard P, Stiasny-Kolster, K., Winkelmann, Juliane, Fietze I, Francavilla Marcella, Schulte, Eva C., Carles Vilariño-Güell, Walter Paulus, Christopher J Earley, Dauvilliers Y, Gieger C, Werner Poewe, Gieger Christian, Frauscher Birgit, Bachmann CG, Wolfgang Oertel, Ondo, W.G., Schulte EC, Guy A Rouleau, Falkenstetter Tina, Klaus Berger, Trenkwalder C, Earley, Christopher J., Fontenille, Claire, Faraco, Juliette, Prokisch, Holger, Juliette Faraco, Paulus, Walter J., Farrer Matthew J., Bertrand Fontaine, Schulte, E., Paulus, W., Ondo, W., Montplaisir, Jacques, Paul Peppard, Trenkwalder Claudia, Illig T, Dauvilliers, Y., Schulte Eva C., Wichmann, H., Thomas Illig, Silander, Kaisa, Winkelmann, J., Paulus W, Johannes Kettunen, Spieler D, Jacques Montplaisir, Peppard Paul, Frauscher B, Earley, C., Zimprich, Alexander, Alexander Zimprich, Falkenstetter, T., Le WD, Fontenille Claire, Rouleau, G.A., Czamara, Darina, Schormair, Barbara, Vodicka P, Spieler, Derek, Karel Sonka, William G Ondo, Paulus, Walter, Peppard, P., Guy A. Rouleau, Frauscher, B., Montplaisir, J., Trenkwalder, Claudia, Marcella Francavilla, Le, W.D., Vilarino-Guell, C., Lin, S., Vilariño Güell C, Poewe, W., Le, W., Prokisch Holger, Fuhs, A., Högl B, Lichtner Peter, Wszolek, Z., Sonka Karel, Wei-Dong Le, Illig, T., Earley, Christopher, J., Fontaine B, Vodicka Pavel, Mignot Emmanuel, Kaffe, M., Faraco Juliette, Barbara Schormair, Christopher J. Earley, Francavilla, M., Kaisa Silander, Xiong, Lan, Schormair B, Ingo Fietze, Prokisch, H., Gschliesser, Viola, Viola Gschliesser, Yves Dauvilliers, Mignot, Emmanuel, Emmanuel Mignot, Kemlink, D., Peter Lichtner, Polo O, Lichtner, Peter, Rouleau, Guy, A., Allen Richard P., Czamara D, Schulte, Eva, C., Karin Stiasny-Kolster, Knauf, Franziska, H-Erich Wichmann, Mignot, E., Lin, Siong-Chi, Zbigniew Wszolek, Perola, Markus, Müller-Myhsok, Bertram, Tina Falkenstetter, Rouleau, Guy A., Gieger, Christian, Fietze, Ingo, Nevsimalova Sona, Lan Xiong, David Kemlink, Derek Spieler, Carles Vilariño-Güell, Zimprich Alexander, Allen RP, Eva C Schulte, Nevsimalova, Sona, Earley, C.J., Farrer, Matthew, J., Czamara Darina, Lin, S.C., Richard P Allen, Allen, R.P., Wichmann, Heinz-Erich, Montplaisir J, Gross, N., Poewe W, Allen, Richard, P., Vávrová Jana, Prokisch H, Christian Gieger, Francavilla, Marcella, Vavrova, Jana, Franziska Knauf, Matthew J. Farrer, Dauvilliers Yves, Rouleau Guy A., Ondo WG, Gross, Nadine, Rouleau GA, Wszolek Z, Schormair Barbara, Falkenstetter T, Eva C. Schulte, Kemlink, David, Ondo, William G., Bachmann, Cornelius, G., Sonka, Karel, Kemlink D, Nevsimalova, S., Andrea Fuhs, Cornelius G Bachmann, Trenkwalder, C., Oertel, W., Farrer MJ, Falkenstetter, Tina, Poewe, Werner, Högl, Birgit, Bachmann Cornelius G., Wichmann H.-Erich, Schormair, B., Claudia Trenkwalder, Xiong Lan, Polo, O., Oertel W, Markus Perola, Farrer, M., Perola, M., Silander Kaisa, Polo Olli, Stiasny-Kolster Karin, Isabelle Cournu-Rebeix, Winkelmann J, Mignot E, Gschliesser Viola, Fontenille, C., Frauscher, Birgit, Nadine Gross, Berger Klaus, Illig, Thomas, Jana Vávrová, Meitinger, Thomas, Fuhs A, Winkelmann Juliane, Rouleau, G., Fuhs Andrea, Farrer, M.J., Earley Christopher J., Peppard, Paul, Birgit Högl, Vodicka, Pavel, Thomas Meitinger, Gross N, Birgit Frauscher, Spieler Derek, Lichtner P, Lin SC, Kettunen, J., Vilarino-Gueell, Carles, Pavel Vodicka, Spieler, D., Silander K, Wszolek, Zbigniew, Nevsimalova S, Claire Fontenille, Holger Prokisch, Knauf Franziska, Jana Vávrová, Rouleau, Guy,, Bachmann, Cornelius,, Schulte, Eva,, Earley, Christopher,, Farrer, Matthew,, Ondo, William,, Allen, Richard,, Winkelmann, J;Czamara, D;Schormair, B;Knauf, F;Schulte, EC;Trenkwalder, C;Dauvilliers, Y;Polo, O;Högl, B;Berger, K;Fuhs, A;Gross, N;Stiasny-Kolster, K;Oertel, W;Bachmann, CG;Paulus, W;Xiong, L;Montplaisir, J;Rouleau, GA;Fietze, I;Vávrová, J;Kemlink, D;Sonka, K;Nevsimalova, S;Lin, SC;Wszolek, Z;Vilarino-Guell, C;Farrer, MJ;Gschliesser, V;Frauscher, B;Falkenstetter, T;Poewe, W;Allen, RP;Earley, CJ;Ondo, WG;Le, WD;Spieler, D;Kaffe, M;Zimprich, A;Kettunen, J;Perola, M;Silander, K;Cournu-Rebeix, I;Francavilla, M;Fontenille, C;Fontaine, B;Vodicka, P;Prokisch, H;Lichtner, P;Peppard, P;Faraco, J;Mignot, E;Gieger, C;Illig, T;Wichmann, HE;Müller-Myhsok, B;Meitinger, T   +326 more
core   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study

Clinical Proteomics
Abstract Background The treatment of advanced or metastatic colorectal cancer (CRC) poses a global challenge. Mendelian Randomization (MR) has been primarily applied for repurposing licensed drugs and uncovering new therapeutic targets. Objective This study aims to systematically identify potential plasma protein targets for CRC using ...
Pan, Zhen-Kun, Wu, Meng-Hua, Shi, Hua, Ni, Yong-Jian, Geng, Quan-Li, Ye, Jin-Sheng   +5 more
openaire   +2 more sources

Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics.

PLoS ONE
While genome-wide association studies (GWAS) have identified genetic variants associated with intelligence, their biological mechanisms remain largely unexplored.
Zheng Zhang, Yousong Zhu, Junlong Zhang, Wenbin He, Cheng Han   +4 more
doaj   +1 more source

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +52 more
core   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Linear and non-linear proteome-wide association studies provide novel insight into venous thromboembolism

Nature Communications
Venous thromboembolism is a life-threatening vascular event with high prevalence and genetic determinants. PWAS has become a popular strategy to identify therapeutic targets of complex diseases. However, the current PWAS model only considers the linear relationship between protein and disease.
Yifan Kong, Wangxia Tang, Haonan Kang, Yunlong Guan, Si Li, Xi Cao, Zhonghe Shao, Yi Jiang, Chaolong Wang, Xingjie Hao   +9 more
openaire   +2 more sources

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]

, 2015
Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C, MacKay, A, Thompson, AG, Porter, MC, Rudge, P, Collinge, J, Lowe, J, Mead, S, Uphill, J, Lukic, A   +9 more
core  

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source