Nature CommunicationsNiemann-Pick disease type C protein 1 (NPC1), classically associated with cholesterol transport and viral entry, has an emerging role in cancer biology.
Shuangyan Li +7 more
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Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
The Yeast Proteome Database (YPD) and Caenorhabditis elegans Proteome Database (WormPD): comprehensive resources for the organization and comparison of model organism protein information [PDF]
, 2000 Maria C. Costanzo
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Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction
Advanced Science, EarlyView.A microfluidic platform of engineered blood vessels is developed to study the role of mechanical forces in immune cell adhesion and extravasation in uremic microenvironments. Elevated pressure increases monocyte activity, with ICAM‐1 as a key driver. Matrix density influences monocyte phenotypes, but the uremic environment consistently promoted a pro ...
Mitesh Rathod +9 more
wiley +1 more source
Establishment and characterization of a new mouse gastric carcinoma cell line, MCC
Cancer Cell InternationalBackground The aim of this study was to establish a primary mouse gastric carcinoma cell line. Methods Gastric adenocarcinoma in the body region was induced in immunocompetent BALB/c mice using N-Methyl-N-nitrosourea and a 2% NaCl solution. Fresh gastric
Yushen Wang, Xianju Li, Yi Wang, Jun Qin
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A Two‐Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto‐Aerotaxis
Advanced Science, EarlyView.Magnetotactic bacteria align with Earth's magnetic field, helping them migrate toward low‐oxygen environments. This study reveals how Magnetospirillum gryphiswaldense uses a specialized flavin adenine dinucleotide (FAD)‐dependent chemoreceptor, composed of two interacting proteins, for precise navigation in oxygen gradients.
Julian Herz +13 more
wiley +1 more source
Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity
Advanced Science, EarlyView.This study uncovers a spatiotemporal regulation of STING activity by linear ubiquitination in antiviral immunity. At the early stage of the infection, LUBAC promotes STING linear ubiquitination to drive its trafficking from the ER to the Golgi apparatus for activation.
Yong Zhang +13 more
wiley +1 more source
GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health
eLifeThe liver is the largest solid organ in the body and is primarily composed of hepatocytes (HCs), endothelial cells (ECs), Kupffer cells (KCs), and hepatic stellate cells (HSCs), which spatially interact and cooperate with each other to maintain liver ...
Dianyuan Zhao +12 more
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Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology [PDF]
, 2000 Steven P. Gygi +4 more
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Organization of the Proteostasis Network of Membraneless Organelles
Advanced Science, EarlyView.A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim +6 more
wiley +1 more source