Results 141 to 150 of about 461,354 (348)
A selective c-Met and Trks inhibitor Indo5 suppresses hepatocellular carcinoma growth
Journal of Experimental & Clinical Cancer Research, 2019 Background Human hepatocellular carcinoma (HCC) lacks effective curative therapy and there is an urgent need to develop a novel molecular-targeted therapy for HCC. Selective tyrosine kinase inhibitors have shown promise in treating cancers including HCC.
Teng Luo +14 more
doaj +1 more source
Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury
Advanced Healthcare Materials, EarlyView.A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum +28 more
wiley +1 more source
Characteristics of the tomato chromoplast revealed by proteomic analysis [PDF]
, 2010 Chromoplasts are non-photosynthetic specialized plastids that are important in ripening tomato fruit (Solanum lycopersicum) since, among other functions, they are the site of accumulation of coloured compounds.
Barsan, Cristina +9 more
core +3 more sources
Proteoforms expand the world of microproteins and short open reading frame-encoded peptides
iScience, 2023 Summary: Microproteins and short open reading frame-encoded peptides (SEPs) can, like all proteins, carry numerous posttranslational modifications. Together with posttranscriptional processes, this leads to a high number of possible distinct protein ...
Liam Cassidy +2 more
doaj
Nature Communications, 2018 Nanoscale or single-cell technologies are critical for biomedical applications. However, current mass spectrometry (MS)-based proteomic approaches require samples comprising a minimum of thousands of cells to provide in-depth profiling.
Ying Zhu +12 more
semanticscholar +1 more source
Advanced Materials, EarlyView.Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li +3 more
wiley +1 more source
solveME: fast and reliable solution of nonlinear ME models. [PDF]
, 2016 BackgroundGenome-scale models of metabolism and macromolecular expression (ME) significantly expand the scope and predictive capabilities of constraint-based modeling.
Ebrahim, Ali +5 more
core +4 more sources
Nature Communications, 2019 We describe pLink 2, a search engine with higher speed and reliability for proteome-scale identification of cross-linked peptides. With a two-stage open search strategy facilitated by fragment indexing, pLink 2 is ~40 times faster than pLink 1 and 3~10 ...
Zhen-Lin Chen +15 more
semanticscholar +1 more source
Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction
Advanced Materials, EarlyView.We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin +17 more
wiley +1 more source
Proteone and secretome of trypanosomes : A standardised analytical method [PDF]
, 2007 During the infection in mammals, the trypanosomes are known to develop strategies to escape host immune responses that are responsible for the immunopathology.
Brizard, Jean-Paul +7 more
core