Results 121 to 130 of about 289,844 (300)

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

New Method and Platforms for Liquid Phase Based Proteome Separation and Identification

, 2011
The complexity of proteome brings great challenge and opportunity to promote the development of new techniques for liquid phase based proteome analysis. In our recent study, with newly developed methods and platforms, great improvement on proteome sample
张玉奎, 张丽华
core  

Standard Guidelines for the Chromosome-Centric Human Proteome Project

, 2012
The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome.
Omenn, Gilbert, Hancock, William, Hancock, William S, Nishimura, Toshihide, Yamamoto, Tadashi, Na, Keun, Baker, Mark S., Garin, Jerome, Salekdeh, Ghasem Hosseini, Lee, Hyoung-Joo, Paik, Young-Ki, Marko-Varga, György, Omenn, Gilbert S., Hanash, Samir, Keown, Paul, Marko-Varga, György,, Binz, Pierre-Alain, Binz, Pierre, Archakov, Alexander, Baker, Mark S, Omenn, Gilbert S, He, Fuchu, Uhlen, Mathias, Bairoch, Amos, Aebersold, Ruedi, Hancock, William S., Bairoch, Amos Marc, Jeong, Seul-Ki, Legrain, Pierre, Baker, Mark D., Uhlén, Mathias,, Yoo, Jong Shin, Lund University., Bergeron, John   +33 more
core   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Proteomics [PDF]

Nature Biotechnology, 2019
openaire   +2 more sources

Novelseparation and identification techniques for proteome study

, 2009
With the in-depth research in proteomics, more and more requirements have been put forward on the development of novel separation and identification techniques for proteome study.
张玉奎
core  

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

The 2024 Report on the Human Proteome from the HUPO Human Proteome Project

The Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two goals: (1) to credibly identify at least one isoform of every protein-coding gene and (2) to make proteomics an integral part of ...
Van Eyk, Jennifer E, Aebersold, Ruedi,, Omenn, Gilbert S.,, Bandeira, Nuno,, Zhang, Gong, Pineau, Charles,, Overall, Christopher M.,, Voelker, Uwe,, Bandeira, Nuno, Budnik, Bogdan, Van Eyk, Jennifer E.,, Weintraub, Susan T.,, Mudge, Jonathan M, Deutsch, Eric W.,, Budnik, Bogdan,, Roehrl, Michael H. A.,, Orchard, Sandra,, Nice, Edouard,, Nice, Edouard, Völker, Uwe, Moritz, Robert L, Deutsch, Eric W, Omenn, Gilbert S, Lindskog, Cecilia, Packer, Nicolle H.,, Roehrl, Michael HA, Mudge, Jonathan M.,, Guo, Tiannan, Aebersold, Ruedi, Lindskog, Cecilia,, Roehrl, Michael H A, Lane, Lydie,, Zhang, Gong,, Packer, Nicolle H, Overall, Christopher M, Weintraub, Susan T, Orchard, Sandra, Pineau, Charles, et al., Guo, Tiannan,, Lane, Lydie, Moritz, Robert L.,   +41 more
core   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

BRISC inactivation alleviates alcohol-induced liver injury in mice

Scientific Reports
BRCC3 isopeptidase complex (BRISC) is a JAMM subfamily deubiquitinase that has been revealed to be required for optional activation of NLRP3 inflammasome and TLR4/NF-κB signaling pathway.
Ting Wang, Wen Zhang, Xian Liu, Kai Liu, Guang-Ming Ren, Shen-Si Xiang, Yi-Qun Zhan, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Yan Li, Xiao-Ming Yang, Rong-Hua Yin   +13 more
doaj   +1 more source