Results 111 to 120 of about 267,519 (299)

Standard Guidelines for the Chromosome-Centric Human Proteome Project

, 2012
The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome.
Omenn, Gilbert, Hancock, William, Hancock, William S, Nishimura, Toshihide, Yamamoto, Tadashi, Na, Keun, Baker, Mark S., Garin, Jerome, Salekdeh, Ghasem Hosseini, Lee, Hyoung-Joo, Paik, Young-Ki, Marko-Varga, György, Omenn, Gilbert S., Hanash, Samir, Keown, Paul, Marko-Varga, György,, Binz, Pierre-Alain, Binz, Pierre, Archakov, Alexander, Baker, Mark S, Omenn, Gilbert S, He, Fuchu, Uhlen, Mathias, Bairoch, Amos, Aebersold, Ruedi, Hancock, William S., Bairoch, Amos Marc, Jeong, Seul-Ki, Legrain, Pierre, Baker, Mark D., Uhlén, Mathias,, Yoo, Jong Shin, Lund University., Bergeron, John   +33 more
core   +1 more source

Nuclear and cytoplasmic specific RNA binding proteome enrichment and its changes upon ferroptosis induction

Nature Communications
The key role of RNA-binding proteins (RBPs) in posttranscriptional regulation of gene expression is intimately tied to their subcellular localization. Here, we show a subcellular-specific RNA labeling method for efficient enrichment and deep profiling of
Haofan Sun, Bin Fu, Xiaohong Qian, Ping Xu, Weijie Qin   +4 more
doaj   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

New Method and Platforms for Liquid Phase Based Proteome Separation and Identification

, 2011
The complexity of proteome brings great challenge and opportunity to promote the development of new techniques for liquid phase based proteome analysis. In our recent study, with newly developed methods and platforms, great improvement on proteome sample
张玉奎, 张丽华
core  

The hydrogen peroxide-sensitive proteome of the chloroplast in vitro and in vivo

, 2013
Muthuramalingam M, Matros A, Scheibe R, Mock H-P, Dietz K-J. The hydrogen peroxide-sensitive proteome of the chloroplast in vitro and in vivo. Frontiers in Plant Science.
Hans-Peter eMock, Hans-Peter Mock, Renate eScheibe, Scheibe, Renate, Meenakumari eMuthuramalingam, Meenakumari Muthuramalingam, Karl-Josef Dietz, Matros, Andrea, Karl-Josef eDietz, Andrea Matros, Dietz, Karl-Josef, Mock, Hans-Peter, Renate Scheibe, Muthuramalingam, Meenakumari, Andrea eMatros   +14 more
core   +1 more source

NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression

Nature Communications
Niemann-Pick disease type C protein 1 (NPC1), classically associated with cholesterol transport and viral entry, has an emerging role in cancer biology.
Shuangyan Li, Lishan Yan, Chaoying Li, Lijuan Lou, Fengjiao Cui, Xiao Yang, Fuchu He, Ying Jiang   +7 more
doaj   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Regulation of lipoprotein processing by GPNMB in foamy macrophages: potential therapeutic targets for atherosclerosis

Nature Communications
The formation of foamy macrophages is often considered a pathological hallmark of atherosclerosis, but the underlying mechanisms remain elusive. Herein, we demonstrated that the transcription factor TFEC could upregulate the expression of Glycoprotein ...
Junqi Wang, Liming Peng, Huan Wang, Di Liu, Wenting Yang, Fang Yan, Dianyuan Zhao, Chunhua Zhang, Ziliang He, Xiao-Ping Chen, Li Tang   +10 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Novelseparation and identification techniques for proteome study

, 2009
With the in-depth research in proteomics, more and more requirements have been put forward on the development of novel separation and identification techniques for proteome study.
张玉奎
core