Results 101 to 110 of about 289,844 (300)

NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression

Nature Communications
Niemann-Pick disease type C protein 1 (NPC1), classically associated with cholesterol transport and viral entry, has an emerging role in cancer biology.
Shuangyan Li, Lishan Yan, Chaoying Li, Lijuan Lou, Fengjiao Cui, Xiao Yang, Fuchu He, Ying Jiang   +7 more
doaj   +1 more source

Plasma Proteome Database as a resource for proteomics research

PROTEOMICS, 2005
AbstractPlasma is one of the best studied compartments in the human body and serves as an ideal body fluid for the diagnosis of diseases. This report provides a detailed functional annotation of all the plasma proteins identified to date. In all, gene products encoded by 3778 distinct genes were annotated based on proteins previously published in the ...
Muthusamy, Babylakshmi, Hanumanthu, G., Suresh, Shubha, Rekha, B., Srinivas, D., Karthick, L., Vrushabendra, B. M., Sharma, Salil, Mishra, Goparani, Chatterjee, Pritam, Mangala, K. S., Nagaraj, Shivashankar H., Chandrika, K. N., Deshpande, Nandan, Suresh, M., Kannabiran, N., Niranjan, Vidya, Nalli, Anuradha, Prasad, T. S. Keshava, Arun, K. S., Reddy, Raghunath, Chandran, Sreenath, Jadhav, Trafina, Julie, D., Mahesh, M., John, S. Lynate, Palvankar, Kshitish, Sudhir, D., Bala, P., Rashmi, N. S., Vishnupriya, G., Dhar, Kaushik, Reshma, S., Chaerkady, Raghothama, Gandhi, T. K. B., Harsha, H. C., Mohan, S. Sujatha, Deshpande, Krishna S., Sarker, Malabika, Pandey, Akhilesh   +39 more
openaire   +5 more sources

The 2023 Report on the Proteome from the HUPO Human Proteome Project.

Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two ...
Van Eyk, Jennifer E, Aebersold, Ruedi,, Omenn, Gilbert S.,, Bandeira, Nuno,, Overall, Christopher M.,, Pineau, Charles,, Liu, Siqi,, Bandeira, Nuno, Van Eyk, Jennifer E.,, Weintraub, Susan T.,, Deutsch, Eric W.,, Cristea, Ileana M.,, Roehrl, Michael H. A.,, Orchard, Sandra,, Nice, Edouard,, Nice, Edouard, Liu, Siqi, Moritz, Robert L, Deutsch, Eric W, Omenn, Gilbert S, Lindskog, Cecilia, Cristea, Ileana M, Packer, Nicolle H.,, Roehrl, Michael HA, Guo, Tiannan, Aebersold, Ruedi, Lindskog, Cecilia,, Roehrl, Michael H A, Lane, Lydie,, Packer, Nicolle H, Overall, Christopher M, Weintraub, Susan T, Orchard, Sandra, Pineau, Charles, Guo, Tiannan,, et al., Lane, Lydie, Moritz, Robert L.,   +37 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Absolute quantification of microvesicular proteome elucidating the origin specific signature

, 2010
1
고용송
core  

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions

Nature Communications
Protein ubiquitination regulates a wide range of cellular processes. The degree of protein ubiquitination is determined by the delicate balance between ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination.
Yuan Liu, Dianke Li, Xin Zhang, Simin Xia, Yingjie Qu, Xinping Ling, Yang Li, Xiangren Kong, Lingqiang Zhang, Chun-Ping Cui, Dong Li   +10 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Nuclear and cytoplasmic specific RNA binding proteome enrichment and its changes upon ferroptosis induction

Nature Communications
The key role of RNA-binding proteins (RBPs) in posttranscriptional regulation of gene expression is intimately tied to their subcellular localization. Here, we show a subcellular-specific RNA labeling method for efficient enrichment and deep profiling of
Haofan Sun, Bin Fu, Xiaohong Qian, Ping Xu, Weijie Qin   +4 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source