Results 31 to 40 of about 437,208 (323)

Subcellular proteomics [PDF]

Nature Reviews Methods Primers, 2021
The eukaryotic cell is compartmentalized into subcellular niches, including membrane-bound and membrane-less organelles. Proteins localize to these niches to fulfil their function, enabling discreet biological processes to occur in synchrony. Dynamic movement of proteins between niches is essential for cellular processes such as signalling, growth ...
Josie A. Christopher, Charlotte Stadler, Claire E. Martin, Marcel Morgenstern, Yanbo Pan, Cora N. Betsinger, David G. Rattray, Diana Mahdessian, Anne-Claude Gingras, Bettina Warscheid, Janne Lehtiö, Ileana M. Cristea, Leonard J. Foster, Andrew Emili, Kathryn S. Lilley   +14 more
openaire   +3 more sources

Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases [PDF]

, 2016
Purpose of review: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years.
Magalhães, Pedro, Mischak, Harald, Zürbig, Petra   +2 more
core   +1 more source

Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-PAINT [PDF]

, 2019
In the brain, the strength of each individual synapse is defined by the complement of proteins present or the "local proteome." Activity-dependent changes in synaptic strength are the result of changes in this local proteome and posttranslational protein
Böger, C., Endesfelder, U., Hafner, A., Heilemann, M., Jungmann, R., Malkusch, S., Schlichthärle, T., Schuman, E., Strauss, M.   +8 more
core   +2 more sources

Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions

Scientific Reports, 2021
Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same domains may differ in different contexts.
Chao Gao, Chong Ma, Huqiang Wang, Haolin Zhong, Jiayin Zang, Rugang Zhong, Fuchu He, Dong Yang   +7 more
doaj   +1 more source

Toward an understanding of the protein interaction network of the human liver

Molecular Systems Biology, 2011
Proteome‐scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery.
Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang   +37 more
doaj   +1 more source

OsteoporosAtlas: a human osteoporosis-related gene database [PDF]

PeerJ, 2019
Background Osteoporosis is a common, complex disease of bone with a strong heritable component, characterized by low bone mineral density, microarchitectural deterioration of bone tissue and an increased risk of fracture.
Xun Wang, Lihong Diao, Dezhi Sun, Dan Wang, Jiarun Zhu, Yangzhige He, Yuan Liu, Hao Xu, Yi Zhang, Jinying Liu, Yan Wang, Fuchu He, Yang Li, Dong Li   +13 more
doaj   +2 more sources

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart, Brewer, Heather M, Camp, David G, II, Depuydt, Geert, Petyuk, Vladislav A, Smith, Richard D, Smolders, Arne, Xie, Fang   +7 more
core   +2 more sources

Apex Peptide Elution Chain Selection: A New Strategy for Selecting Precursors in 2D-LC-MALDI-TOF/TOF Experiments on Complex Biological Samples [PDF]

, 2010
LC-MALDI provides an often overlooked opportunity to exploit the separation between LC-MS and MS/MS stages of a 2D-LC-MS-based proteomics experiment, that is, by making a smarter selection for precursor fragmentation. Apex Peptide Elution Chain Selection
Breitling, Rainer,, Fusetti, Fabrizia,, Gandhi, Tejas,, Permentier, Hjalmar P.,, Poolman, Bert,, Wiederhold, Elena,   +5 more
core   +7 more sources

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

Nature Communications, 2019
Neutrophils and macrophages are both involved in the initiation of inflammation, but whether and how they may participate in inflammation resolution is unclear.
Wenting Yang, Yuandong Tao, Yan Wu, Xinyuan Zhao, Weijie Ye, Dianyuan Zhao, Ling Fu, Caiping Tian, Jing Yang, Fuchu He, Li Tang   +10 more
doaj   +1 more source

A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development

EvoDevo, 2018
Background How genome complexity affects organismal phenotypic complexity is a fundamental question in evolutionary developmental biology. Previous studies proposed various contributing factors of genome complexity and tried to find the connection ...
Dong Yang, Aishi Xu, Pan Shen, Chao Gao, Jiayin Zang, Chen Qiu, Hongsheng Ouyang, Ying Jiang, Fuchu He   +8 more
doaj   +1 more source