Results 61 to 70 of about 437,208 (323)
Proteomics of the Spermatozoon [PDF]
Balkan Journal of Medical Genetics, 2012 ABSTRACT The study of the sperm proteins is crucial for understanding its normal function and alterations in infertile patients. The sperm is a highly specialized cell with a very large flagella, with little cytoplasm and a highly condensed nucleus. The most abundant proteins in the nucleus of mammalian sperm are the protamines. The main functions
JL Ballescá, R Oliva
openaire +4 more sources
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
solveME: fast and reliable solution of nonlinear ME models. [PDF]
, 2016 BackgroundGenome-scale models of metabolism and macromolecular expression (ME) significantly expand the scope and predictive capabilities of constraint-based modeling.
Ebrahim, Ali +5 more
core +4 more sources
A List of Candidate Cancer Biomarkers for Targeted Proteomics
Biomarker Insights, 2006 We have compiled from literature and other sources a list of 1261 proteins believed to be differentially expressed in human cancer. These proteins, only some of which have been detected in plasma to date, represent a population of candidate plasma ...
Malu Polanski, N. Leigh Anderson
doaj +1 more source
Scientific Data, 2022 Measurement(s) protein expression profiling Technology Type(s) Mass ...
Ran Kong, Xiaohong Qian, Wantao Ying
doaj +1 more source
Proteomics in Diagnostics [PDF]
Disease Markers, 2004 For many diseases, such as heart disease and cancer, early detection plays a pivotal role in the survival rate of the patient. When detected early, many such lethal diseases can be effectively treated with existing remedies. The difficulty remains, however, how to effectively detect such conditions at the earliest possible stage with a high enough ...
Timothy D. Veenstra, Sudhir Srivastava
openaire +3 more sources
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
COVID‐19 diagnostic testing: Technology perspective
Clinical and Translational Medicine, 2020 The corona virus disease 2019 (COVID‐19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
Meng Xu +10 more
doaj +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Protein palmitoylation plays an important role in Trichomonas vaginalis adherence [PDF]
, 2018 The flagellated protozoan parasite Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted infection worldwide.
Corvi, Maria Martha +6 more
core +2 more sources