Results 41 to 50 of about 491,374 (284)
Soluble CD72, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity
Frontiers in ImmunologyBackgroundCD72 is a highly required regulatory molecule in B cells. Its sufficient expression is crucial for maintaining self-tolerance. In contrast, soluble CD72 (sCD72) is reported to be increased in the serum of autoimmune diseases such as systemic ...
Nasren Eiza +6 more
doaj +1 more source
Scientific Reports, 2017 MYST histone acetyltransferases have crucial functions in transcription, replication and DNA repair and are hence implicated in development and cancer.
Mercedes Pardo +8 more
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Single-cell long-read targeted sequencing reveals transcriptional variation in ovarian cancer
Nature CommunicationsSingle-cell RNA sequencing predominantly employs short-read sequencing to characterize cell types, states and dynamics; however, it is inadequate for comprehensive characterization of RNA isoforms. Long-read sequencing technologies enable single-cell RNA
Ashley Byrne +12 more
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Cerrena unicolor Laccases, Genes Expression and Regulation of Activity
Biomolecules, 2021 A white rot fungus Cerrena unicolor has been identified as an important source of laccase, unfortunately regulation of this enzyme genes expression is poorly understood.
Anna Pawlik +10 more
doaj +1 more source
In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability [PDF]
, 2016 Endothelial cells (ECs) form the inner layer of blood vessels and physically separate the blood from the surrounding tissue. To support tissues with nutrients and oxygen, the endothelial monolayer is semipermeable.
Anderson, Kurt I. +7 more
core +10 more sources
Clinica Chimica Acta, 2005 With the increase in the number of genome sequencing projects, there is a concomitant exponential growth in the number of protein sequences whose function is still unknown. Functional proteomics constitutes an emerging research area in the proteomic field whose approaches are addressed towards two major targets: the elucidation of the biological ...
MONTI, MARIA +3 more
openaire +4 more sources
, 2007 Our knowledge of the complex synaptic proteome and its relationship to physiological or pathological conditions is rapidly expanding. This has been greatly accelerated by the application of various evolving proteomic techniques, enabling more efficient protein resolution, more accurate protein identification, and more comprehensive characterization of ...
Fengju, Bai, Frank A, Witzmann
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Transcriptomic and proteomic analysis of Oenococcus oeni adaptation to wine stress conditions
Frontiers in Microbiology, 2016 Oenococcus oeni, the main lactic acid bacteria responsible for malolactic fermentation in wine, has to adapt to stressful conditions, such as low pH and high ethanol content. In this study, the changes in the transcriptome and the proteome of O. oeni PSU-
Mar Margalef-Català +4 more
doaj +1 more source
Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]
, 2015 Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F +64 more
core +2 more sources